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Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer
One of the most important therapeutic interventions for non-small cell lung cancer is radiotherapy. Ionizing radiation (IR) is classified by...
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Cancer metastasis as a non-healing wound
Most cancer deaths are caused by metastasis: recurrence of disease by disseminated tumour cells at sites distant from the primary tumour. Large...
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Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting...
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Redefining intestinal immunity with single-cell transcriptomics
The intestinal immune system represents the largest collection of immune cells in the body and is continually exposed to antigens from food and the...
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Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer
Purpose of ReviewCastration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to...
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Marine-derived microbes and molecules for drug discovery
Increasing attention has been paid to marine-derived biomolecules as sources of therapeutics for autoimmune diseases. Nagasaki Prefecture has many...
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Camelid Single-Domain Antibodies for the Development of Potent Diagnosis Platforms
The distinct biophysical and pharmaceutical properties of camelid single-domain antibodies, referred to as VHHs or nanobodies, are associated with...
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Immunogenetics of Lupus Erythematosus
Lupus erythematosus (LE) is a heterogeneous disease with a wide range of manifestations ranging from localized lesions in cutaneous lupusCutaneous...
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Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota
Serum antibodies can recognize both pathogens and commensal gut microbiota. However, our current understanding of antibody repertoires is largely...
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CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy
Adoptive cell therapy with chimeric antigen receptor (CAR) immunotherapy has made tremendous progress with five CAR T therapies approved by the US...
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Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
Colorectal cancer is the third most common and the second deadliest cancer worldwide. To date, colorectal cancer becomes one of the most important...
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Proteomics to study cancer immunity and improve treatment
Cancer survival and progression depend on the ability of tumor cells to avoid immune recognition. Advances in the understanding of cancer immunity...
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Proceedings of the inaugural Dark Genome Symposium: November 2022
In November 2022 the first Dark Genome Symposium was held in Boston, USA. The meeting was hosted by Rome Therapeutics and Enara Bio, two...
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Current Progress and Prospects for a Buruli Ulcer Vaccine
Buruli ulcer (BU), one of the skin-related neglected tropical diseases (skin NTDs), is a necrotizing and disabling cutaneous disease caused by...
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Multiparameter Flow Cytometry Monitoring of T Cell Responses
Multiparameter flow cytometry is a common tool for assessing responses of T, B, and other cells to pathogens or vaccines. Such responses are likely...
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Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Diseases associated with chronic inflammation constitute a major health burden across the world. As central instigators of the inflammatory response...
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Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis
Immune-mediated nephritis is a leading cause of acute kidney injury and chronic kidney disease. While the role of B cells and antibodies has been...
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Epigenetic modulation of antitumor immunity for improved cancer immunotherapy
Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also in the activation, differentiation and effector...
