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Precision medicine in perinatal depression in light of the human microbiome
Perinatal depression is the most common complication of pregnancy and affects the mother, fetus, and infant. Recent preclinical studies and a limited...
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Specific Populations: Clinical Pharmacology Considerations
The ultimate goal of new drug development is to not only show the safety and effectiveness of a drug, but also to ensure that the right dosage is...
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Synthetic Chemicals: What We Have Learned and Still Need to Learn About Their Associations with Childhood Allergy and Asthma
Purpose of ReviewPrenatal and childhood exposure to synthetic chemicals, such as phenols and phthalates, have been linked to asthma and allergy, but...
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Exome sequencing contributes to identify comorbidities in a rare case of infant ARDS induced by the CD40LG mutation
BackgroundAcute respiratory distress syndrome (ARDS) causes significant mortality in young children with certain diseases. Early diagnosis and...
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Advances in free fatty acid profiles in gestational diabetes mellitus
The morbidity of gestational diabetes mellitus (GDM) is increasing and is associated with adverse perinatal outcomes and long-term maternal and...
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Identification of maternal attitudes and knowledge about newborn screenings: a Turkey sample
This study was planned to determine maternal attitudes and knowledge about newborn screening. The universe of the descriptive study consisted of...
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Genetic screening of relatives of decedents experiencing sudden unexpected death: medical examiner’s office referrals to a multi-disciplinary cardiogenetics program
Currently, no standardized system exists for evaluating and testing at-risk family members of decedents with abnormal post-mortem genetic testing in...
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Alloparental Care and Postnatal Development of Heterozygous TPH2 Transgenic Mice
AbstractThe issue of the relationship between the transmission of a negative effect from a depressed mother to her offspring is one of the priorities...
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Antimicrobial Agents Induced Microbiome Dysbiosis Its Impact on Immune System and Metabolic Health
The role of antimicrobial agents like antibiotics and antiseptics in their clinical use in treating various diseases and in their non-medicinal uses...
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Mitochondrial DNA copy number variation across three generations: a possible biomarker for assessing perinatal outcomes
BackgroundMitochondria have their own circular multi-copy genome (mtDNA), and abnormalities in the copy number are implicated in mitochondrial...
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Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges
Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several...
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Perampanel effectiveness in treating ROGDI-related Kohlschütter-Tönz syndrome: first reported case in China and literature review
PurposeThis study reported the first case of Kohlschütter-Tönz syndrome (KTS) in China and reviewed the literature of the reported cases.
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Prophylactic Treatment of ASD Based on Sleep-Wake Circadian Rhythm Formation in Infancy to Early Childhood
The pathogenesis underlying autism spectrum disorder (ASD) and the causes of rapid increase of ASD patients remain unclear. However, recent reports...
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Re-evaluating the relationship between missing heritability and the microbiome
Human genome-wide association studies (GWASs) have recurrently estimated lower heritability estimates than familial studies. Many explanations have...
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Effect of bisphenol A on the neurological system: a review update
Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide. BPA can be found in epoxy...
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Effects of Weight Gain During Pregnancy in Normal-Weight Women on Changes in the Gut Microbiota of Pregnant Women in the Third Trimester
With the improvement of living standards and the lack of nutrition awareness during pregnancy, the phenomenon of excessive weight gain (EWG) of...
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Plasmodium falciparum infection and disease in infancy associated with increased risk of malaria and anaemia in childhood
BackgroundInfants under 6 months of age are often excluded from malaria surveillance and observational studies. The impact of malaria during early...
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Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease
Prenatal and early postnatal life represent key periods of immune system development. In addition to genetics and host biology, environment has a...
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Dynamics of the infant gut microbiota in the first 18 months of life: the impact of maternal HIV infection and breastfeeding
BackgroundAccess to antiretroviral therapy (ART) during pregnancy and breastfeeding for mothers with HIV has resulted in fewer children acquiring HIV...
