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In Vitro and Ex Vivo Methodologies for T-Cell Trafficking Through Blood–Brain Barrier After TLR Activation
This chapter describes ex vivo isolation of human T cells and of naïve splenocytes respectively collected from multiple sclerosis patients and...
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Synbiotics in Hepatocellular Carcinoma
Cancer is a deadly disease that affect a wide range of population worldwide. It is accounting for nearly 10 million deaths in 2020, or nearly one in...
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Microorganisms in the Pathogenesis and Management of Primary Biliary Cholangitis (with Focus on SARS-CoV-2 & Gut Microbiota)
Primary biliary cholangitis is a chronic cholestatic liver disease characterized by a selective and progressive destruction of interlobular bile...
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Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics
Atherosclerosis, one of the life-threatening cardiovascular diseases (CVDs), has been demonstrated to be a chronic inflammatory disease, and...
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Amelioration of Neuropathic Pain and Attenuation of Neuroinflammation Responses by Tetrahydropalmatine Through the p38MAPK/NF-κB/iNOS Signaling Pathways in Animal and Cellular Models
Neuropathic pain (NP) treatment remains a challenge because the pathomechanism is not yet fully understood. Because of low treatment efficacy, there...
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Clinical Trial with Synbiotics in Various Disease State
Simultaneous use of prebiotics and probiotics for human health benefit is generally called synbiotic. Prebiotics is nonviable nutritional food...
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Role of Toll-Like Receptors in Molecular and Cellular Mechanisms of Respiratory Diseases
The family of toll-like receptors (TLRs) is receiving considerable attention as potential regulators and controllers of the immune response through...
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Interleukin-1β and interleukin-6 in Common Variable Immunodeficiency and their association with subtypes of B cells and response to the Pneumovax-23 vaccine
Introduction : Common Variable Immunodeficiency (CVID) is the most common symptomatic form of primary immunodeficiencies. Current research data show...
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Biomarkers of Sepsis and a Focus on PCSK9
Sepsis is a time-dependent disease and a prompt diagnosis and treatment may improve the outcome. In the actuality, we do not have a reliable...
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Impact of curcumin on p38 MAPK: therapeutic implications
Curcumin (diferuloylmethane) is a herbal remedy which possesses numerous biological attributes including anti-inflammatory, anti-oxidant and...
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The value of plasma presepsin as a diagnostic and prognostic biomarker for sepsis in Southern China
BackgroundPresepsin is a soluble CD14 subtype that has been considered as a novel marker for patients with sepsis. This study explored the clinical...
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Implications of Probiotics and Prebiotics on Immune Functions
Kee** the digestive system healthy is a foundation stone to general health and well-being. More than 75% of our immunity lies in the gut. The...
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Genome-Wide Mutagenesis in Mice: In Search for Genes Regulating Immune Responses and Inflammation
AbstractGenome-wide mutagenesis induced by N -ethyl- N -nitrosourea (ENU) results in efficient introduction of mutations into the genome of mammalian...
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Synergistic Herb-Drug Interactions Against Bacteria
Pharmacodynamic phytochemical/extract-antibiotic interactions can modify the efficacy of the antibiotic by reversal of antibiotic resistance...
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The NLR gene family: from discovery to present day
The mammalian NLR gene family was first reported over 20 years ago, although several genes that were later grouped into the family were already known...
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Toll-Like Receptors (TLRs) in Health and Disease: An Overview
Toll-like receptors were discovered as proteins playing a crucial role in the dorsoventral patterning during embryonic development in the Drosophila...
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Host-vaginal microbiota interaction: sha** the vaginal microenvironment and bacterial vaginosis
Purpose of reviewThis review comprehensively examines host-vaginal microbiota interactions, the composition of the vaginal microbiota, and its...
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The Opportunity of Surfactant Protein D as a Potential Biomarker for Detecting Acute Lung Injury
Acute lung injury is a medical problem that causes a high mortality rate if it is not detected early and followed by appropriate treatment. The...
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In silico analysis of virulence factors of Streptococcus uberis for a chimeric vaccine design
Streptococcus uberis is one of the causative agents of bovine mastitis, which has detrimental effects on animal health and the dairy industry....
