Implications of Probiotics and Prebiotics on Immune Functions

  • Chapter
  • First Online:
Prebiotics, Probiotics and Nutraceuticals
  • 556 Accesses

Abstract

Kee** the digestive system healthy is a foundation stone to general health and well-being. More than 75% of our immunity lies in the gut. The microbes that we harbor in and on our body (the microbiota) is crucial for the GIT functioning and thus immunity. An optimal balance between the good and bad bacteria is the key to good health and stronger immunity. Various lifestyle patterns like incorrect food habits, junk food, faulty sleep patterns, and fast life create imbalance in microbiota causing dysbiosis. Dysbiosis is the root cause of several diseases including hypertension, diabetes, cancer, cardiovascular issues, etc. Incorporating functional foods like probiotics, prebiotics, and their combination (synbiotics) in daily diet helps in selective proliferation of the good bacteria in the gut, and this helps in overcoming the dysbiosis. Probiotics have been assessed for multiple properties like cholesterol-lowering effects and anti-carcinogenic activity. Probiotics exhibit immunomodulatory effects on the hosts. This chapter discusses the effects of probiotic and prebiotic consumption on the immune homeostasis function. Mechanisms of probiosis and prebiosis have been elaborated upon. Although there are numerous studies described in the scientific literature regarding the beneficial effects obtained from the consumption of probiotics, some cases of side effects also prevail which have been taken account of in this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
EUR 29.95
Price includes VAT (France)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 117.69
Price includes VAT (France)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 158.24
Price includes VAT (France)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
EUR 158.24
Price includes VAT (France)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Al-Sheraji SH, Ismail A, Manap MY, Mustafa S, Yusof RM, Hassan FA (2013) Prebiotics as functional foods: a review. J Funct Foods 5(4):1542–1553

    Article  CAS  Google Scholar 

  • Ashaolu TJ (2020) Immune boosting functional foods and their mechanisms: a critical evaluation of probiotics and prebiotics. Biomed Pharmacother 130:110625

    Article  CAS  PubMed  Google Scholar 

  • Atarashi K, Umesaki Y, Honda K (2011) Microbiotal influence on T cell subset development. Semin Immunol 23(2):146–153

    Article  CAS  PubMed  Google Scholar 

  • Azad M, Kalam A, Sarker M, Wan D (2018) Immunomodulatory effects of probiotics on cytokines profiles. BioMed Res Int. 2018;8063647. doi: https://doi.org/10.1155/2018/8063647

  • Bazanella M, Maier TV, Clavel T, Lagkouvardos I, Lucio M, Maldonado-Gòmez MX, Autran C, Walter J, Bode L, Schmitt-Kopplin P, Haller D (2017) Randomized controlled trial on the impact of early-life intervention with bifidobacteria on the healthy infant fecal microbiota and metabolome. Am J Clin Nutr 106(5):1274–1286

    CAS  PubMed  Google Scholar 

  • Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A (2012) Probiotic mechanisms of action. Ann Nutr Metab 61(2):160–174

    Article  CAS  PubMed  Google Scholar 

  • Braathen G, Ingildsen V, Twetman S, Ericson D, Jørgensen MR (2017) Presence of Lactobacillus reuteri in saliva coincide with higher salivary IgA in young adults after intake of probiotic lozenges. Benef Microbes 8(1):17–22

    Article  CAS  PubMed  Google Scholar 

  • Cencic A, Chingwaru W (2010) The role of functional foods, nutraceuticals, and food supplements in intestinal health. Nutrients 2(6):611–625

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cho YJ, Lee HG, Seo KH, Yokoyama W, Kim H (2018) Antiobesity effect of prebiotic polyphenol-rich grape seed flour supplemented with probiotic kefir-derived lactic acid bacteria. J Agric Food Chem 66(47):12498–12511

    Article  CAS  PubMed  Google Scholar 

  • Clarke ST, Green-Johnson JM, Brooks SP, Ramdath DD, Bercik P, Avila C, Inglis GD, Green J, Yanke LJ, Selinger LB, Kalmokoff M (2016) β2-1Fructan supplementation alters host immune responses in a manner consistent with increased exposure to microbial components: results from a double-blinded, randomised, cross-over study in healthy adults. Br J Nutr 115(10):1748–1759

    Article  CAS  PubMed  Google Scholar 

  • Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, Berenjian A, Ghasemi Y (2019) Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods 8(3):92

    Article  CAS  PubMed Central  Google Scholar 

  • Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M (2014) A systematic review of the safety of probiotics. Expert Opin Drug Saf 13(2):227–239

    Article  PubMed  Google Scholar 

  • Dong H, Rowland I, Tuohy KM, Thomas LV, Yaqoob P (2010) Selective effects of Lactobacillus casei Shirota on T cell activation, natural killer cell activity and cytokine production. Clin Exp Immunol 161(2):378–388

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Donkor ON, Ravikumar M, Proudfoot O, Day SL, Apostolopoulos V, Paukovics G, Vasiljevic T, Nutt SL, Gill H (2012) Cytokine profile and induction of T helper type 17 and regulatory T cells by human peripheral mononuclear cells after microbial exposure. Clin Exp Immunol 167(2):282–295

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Du W, Xu H, Mei X, Cao X, Gong L, Wu Y, Li Y, Yu D, Liu S, Wang Y, Li W (2018) Probiotic Bacillus enhance the intestinal epithelial cell barrier and immune function of piglets. Benef Microbes 9(5):743–754

    Article  CAS  PubMed  Google Scholar 

  • Estruel-Amades S, Massot-Cladera M, Pérez-Cano FJ, Franch À, Castell M, Camps-Bossacoma M (2019) Hesperidin effects on gut microbiota and gut-associated lymphoid tissue in healthy rats. Nutrients 11(2):324

    Article  CAS  PubMed Central  Google Scholar 

  • Ezendam J, van Loveren H (2006) Probiotics: immunomodulation and evaluation of safety and efficacy. Nutr Rev 64(1):1–14

    Article  PubMed  Google Scholar 

  • Faith JJ, Guruge JL, Charbonneau M, Subramanian S, Seedorf H, Goodman AL, Clemente JC, Knight R, Heath AC, Leibel RL, Rosenbaum M (2013) The long-term stability of the human gut microbiota. Science 341(6141):1237439

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Galdeano CM, Cazorla SI, Dumit JML, Vélez E, Perdigón G (2019) Beneficial effects of probiotic consumption on the immune system. Ann Nutr Metab 74(2):115–124

    Article  CAS  Google Scholar 

  • Gensollen T, Iyer SS, Kasper DL, Blumberg RS (2016) How colonization by microbiota in early life shapes the immune system. Science 352(6285):539–544

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ et al (2017) Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14(8):491

    Article  PubMed  Google Scholar 

  • Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, Krabshuis J, Le Mair T, Kaufmann P, De Paula JA, Fedorak R (2008) World Gastroenterology Organisation practice guideline: probiotics and prebiotics—May 2008: guideline. South Afri Gastroenterol Rev 6(2):14–25

    Google Scholar 

  • Hardy H, Harris J, Lyon E, Beal J, Foey AD (2013) Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients 5(6):1869–1912

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hasler CM (1998) Pre-and probiotics: where are we today? Introduction. Br J Nutr 80(4):S195

    Article  CAS  PubMed  Google Scholar 

  • Hemaiswarya S, Raja R, Ravikumar R, Carvalho IS (2013) Mechanism of action of probiotics. Braz Arch Biol Technol 56(1):113–119

    Article  CAS  Google Scholar 

  • Hijova E, Chmelarova A (2007) Short chain fatty acids and colonic health. Bratisl Lek List 108(8):354

    CAS  Google Scholar 

  • Horvath A, Leber B, Schmerboeck B, Tawdrous M, Zettel G, Hartl A, Madl T, Stryeck S, Fuchs D, Lemesch S, Douschan P (2016) Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis. Aliment Pharmacol Ther 44(9):926–935

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hui YH, Evranuz EÖ (eds) (2012) Handbook of fermented food and beverage technology two volume set. CRC

    Google Scholar 

  • Ibrahim NS, Ooi FK, Chen CK, Muhamad AS (2017) Effects of probiotics supplementation and circuit training on immune responses among sedentary young males. J Sports Med Phys Fitness 58(7-8):1102–1109

    PubMed  Google Scholar 

  • Ivison SM, Wang C, Himmel ME, Sheridan J, Delano J, Mayer ML, Yao Y, Kifayet A, Steiner TS (2010) Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin. Am J Physiol Gastrointest Liver Physiol 299(3):G733–G741

    Article  CAS  PubMed  Google Scholar 

  • Jain S (2020) Probiotics and their significance in therapeutic nutrition. IP J Nutr Metab Health Sci 3(1):13–21

    Article  Google Scholar 

  • Jakobsdottir G, Blanco N, Xu J, Ahrné S, Molin G, Sterner O, Nyman M (2013) Formation of short-chain fatty acids, excretion of anthocyanins, and microbial diversity in rats fed blackcurrants, blackberries, and raspberries. J Nutr Metab. 2013:202534. doi: https://doi.org/10.1155/2013/202534

  • Kaminogawa S, Nanno M (2004) Modulation of immune functions by foods. Evid Based Complement Alternat Med 1(3):241–250

    Article  PubMed  PubMed Central  Google Scholar 

  • Kato-Kataoka A, Nishida K, Takada M, Kawai M, Kikuchi-Hayakawa H, Suda K, Ishikawa H, Gondo Y, Shimizu K, Matsuki T, Kushiro A (2016) Fermented milk containing Lactobacillus casei strain Shirota preserves the diversity of the gut microbiota and relieves abdominal dysfunction in healthy medical students exposed to academic stress. Appl Environ Microbiol 82(12):3649–3658

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Keller MK, Brandsborg E, Holmstrøm K, Twetman S (2018) Effect of tablets containing probiotic candidate strains on gingival inflammation and composition of the salivary microbiome: a randomised controlled trial. Benef Microbes 9(3):487–494

    Article  CAS  PubMed  Google Scholar 

  • Khare A, Thorat G, Bhimte A, Yadav V (2018) Mechanism of action of prebiotic and probiotic. J Entomol Zool Stud 6(4):51–53

    Google Scholar 

  • Kim CJ, Walmsley SL, Raboud JM, Kovacs C, Coburn B, Rousseau R, Reinhard R, Rosenes R, Kaul R (2016) Can probiotics reduce inflammation and enhance gut immune health in people living with HIV: study designs for the Probiotic Visbiome for Inflammation and Translocation (PROOV IT) pilot trials. HIV Clin Trials 17(4):147–157

    Article  CAS  PubMed  Google Scholar 

  • Lopez-Varela S, González-Gross M, Marcos A (2002) Functional foods and the immune system: a review. Eur J Clin Nutr 56(3):S29–S33

    Article  CAS  PubMed  Google Scholar 

  • Louis P, Flint HJ, Michel C (2016) How to manipulate the microbiota: prebiotics. Microbiota of the human body 119-142

    Google Scholar 

  • Makino S, Ikegami S, Kume A, Horiuchi H, Sasaki H, Orii N (2010) Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1. Br J Nutr 104(7):998–1006

    Article  CAS  PubMed  Google Scholar 

  • Marcial GE, Ford AL, Haller MJ, Gezan SA, Harrison NA, Cai D, Meyer JL, Perry DJ, Atkinson MA, Wasserfall CH, Garrett T (2017) Lactobacillus johnsonii N6. 2 modulates the host immune responses: a double-blind, randomized trial in healthy adults. Front Immunol 8:655

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Martens K, Pugin B, De Boeck I, Spacova I, Steelant B, Seys SF, Lebeer S, Hellings PW (2018) Probiotics for the airways: potential to improve epithelial and immune homeostasis. Allergy 73(10):1954–1963

    Article  CAS  PubMed  Google Scholar 

  • Mathipa MG, Thantsha MS (2017) Probiotic engineering: towards development of robust probiotic strains with enhanced functional properties and for targeted control of enteric pathogens. Gut Pathog 9(1):28

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • McKeen S, Young W, Mullaney J, Fraser K, McNabb WC, Roy NC (2019) Infant complementary feeding of prebiotics for the microbiome and immunity. Nutrients 11(2):364

    Article  CAS  PubMed Central  Google Scholar 

  • Methé BA, Nelson KE, Pop M, Creasy HH, Giglio MG, Huttenhower C, Gevers D, Petrosino JF, Abubucker S, Badger JH, Chinwalla AT (2012) A framework for human microbiome research. Nature 486(7402):215

    Article  CAS  PubMed Central  Google Scholar 

  • Miller LE, Lehtoranta L, Lehtinen MJ (2017) The effect of Bifidobacterium animalis ssp. lactis HN019 on cellular immune function in healthy elderly subjects: systematic review and meta-analysis. Nutrients 9(3):191

    Article  CAS  PubMed Central  Google Scholar 

  • Miyazawa K, Kawase M, Kubota A, Yoda K, Harata G, Hosoda M, He F (2015) Heat-killed Lactobacillus gasseri can enhance immunity in the elderly in a double-blind, placebo-controlled clinical study. Benef Microbes 6(4):441–449

    Article  CAS  PubMed  Google Scholar 

  • Morrison DJ, Preston T (2016) Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes 7(3):189–200

    Article  PubMed  PubMed Central  Google Scholar 

  • Mudd AT, Alexander LS, Berding K, Waworuntu RV, Berg BM, Donovan SM, Dilger RN (2016) Dietary prebiotics, milk fat globule membrane, and lactoferrin affects structural neurodevelopment in the young piglet. Front Pediatr 4:4

    Article  PubMed  PubMed Central  Google Scholar 

  • Nedaei S, Noori A, Valipour A, Khanipour AA, Hoseinifar SH (2019) Effects of dietary galactooligosaccharide enriched commercial prebiotic on growth performance, innate immune response, stress resistance, intestinal microbiota and digestive enzyme activity in Narrow clawed crayfish (Astacus leptodactylus Eschscholtz, 1823). Aquaculture 499:80–89

    Article  CAS  Google Scholar 

  • Nyangale EP, Farmer S, Cash HA, Keller D, Chernoff D, Gibson GR (2015) Bacillus coagulans GBI-30, 6086 modulates Faecalibacterium prausnitzii in older men and women. J Nutr 145(7):1446–1452

    Article  CAS  PubMed  Google Scholar 

  • O’Flaherty S, Saulnier D, Pot B, Versalovic J (2010) How can probiotics and prebiotics impact mucosal immunity? Gut microbes 1(5):293–300

    Article  PubMed  PubMed Central  Google Scholar 

  • O’Hara AM, Shanahan F (2007) Mechanisms of action of probiotics in intestinal diseases. ScientificWorldJournal 7:1–46

    Google Scholar 

  • Pandey KR, Naik SR, Vakil BV (2015) Probiotics, prebiotics and synbiotics—a review. J Food Sci Technol 52(12):7577–7587

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patel S, Goyal A (2012) The current trends and future perspectives of prebiotics research: a review. 3 Biotech 2(2):115–125

    Article  CAS  PubMed Central  Google Scholar 

  • Peña AS (2007) Intestinal flora, probiotics, prebiotics, synbiotics and novel foods. Rev Esp Enferm Dig 99(11):653

    PubMed  Google Scholar 

  • Perdijk O, Van Baarlen P, Fernandez-Gutierrez MM, Van Den Brink E, Schuren FH, Brugman S, Savelkoul HF, Kleerebezem M, Van Neerven RJ (2019) Sialyllactose and galactooligosaccharides promote epithelial barrier functioning and distinctly modulate microbiota composition and short chain fatty acid production in vitro. Front Immunol 10:94

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pu F, Guo Y, Li M, Zhu H, Wang S, Shen X, He M, Huang C, He F (2017) Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: a randomized controlled open-label trial. Clin Interv Aging 12:1223

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roberfroid MB (2000) Prebiotics and probiotics: are they functional foods? Am J Clin Nutr 71(6):1682S–1687S

    Article  CAS  PubMed  Google Scholar 

  • Saito Y, Fujii M, Watanabe T, Maruyama K, Kowatari Y, Ogata H, Kumagai T (2017) Randomized, double-blind, placebo-controlled, parallel-group study of the effect of Lactobacillus paracasei K71 intake on salivary release of secretory immunoglobulin A. Biosci Microbiota Food Health 36(2):55–63. https://doi.org/10.12938/bmfh.16-022

    Article  CAS  PubMed  Google Scholar 

  • Sang Y, Blecha F (2008) Antimicrobial peptides and bacteriocins: alternatives to traditional antibiotics. Anim Health Res Rev 9(2):227–235

    Article  PubMed  Google Scholar 

  • Saulnier DM, Spinler JK, Gibson GR, Versalovic J (2009) Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods. Curr Opin Biotechnol 20(2):135–141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schley PD, Field CJ (2002) The immune-enhancing effects of dietary fibres and prebiotics. Br J Nutr 87(S2):S221–S230

    Article  CAS  PubMed  Google Scholar 

  • Shah NP (2001) Functional foods from probiotics and prebiotics: functional foods from probiotics and prebiotics. Food Technol 55(11):46–53

    CAS  Google Scholar 

  • Shoaib M, Shehzad A, Omar M, Rakha A, Raza H, Sharif HR, Shakeel A, Ansari A, Niazi S (2016) Inulin: properties, health benefits and food applications. Carbohydr Polym 147:444–454

    Article  CAS  PubMed  Google Scholar 

  • Shokryazdan P, Jahromi MF, Navidshad B, Liang JB (2017) Effects of prebiotics on immune system and cytokine expression. Med Microbiol Immunol 206(1):1–9

    Article  CAS  PubMed  Google Scholar 

  • Song SK, Beck BR, Kim D, Park J, Kim J, Kim HD, Ringø E (2014) Prebiotics as immunostimulants in aquaculture: a review. Fish Shellfish Immunol 40(1):40–48

    Article  CAS  PubMed  Google Scholar 

  • Stefaniak T, Madej JP, Graczyk S, Siwek M, Łukaszewicz E, Kowalczyk A, Sieńczyk M, Bednarczyk M (2019) Selected prebiotics and synbiotics administered in ovo can modify innate immunity in chicken broilers. BMC Vet Res 15(1):105

    Article  PubMed  PubMed Central  Google Scholar 

  • Swennen K, Courtin CM, Delcour JA (2006) Non-digestible oligosaccharides with prebiotic properties. Crit Rev Food Sci Nutr 46(6):459–471

    Article  CAS  PubMed  Google Scholar 

  • Szajewska H, Guarino A, Hojsak I, Indrio F, Kolacek S, Shamir R, Vandenplas Y, Weizman Z (2014) Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 58(4):531–539

    Article  PubMed  Google Scholar 

  • Thursby E, Juge N (2017) Introduction to the human gut microbiota. Biochem J 474(11):1823–1836

    Article  CAS  PubMed  Google Scholar 

  • Van den Abbeele P, Taminiau B, Pinheiro I, Duysburgh C, Jacobs H, Pijls L, Marzorati M (2018) Arabinoxylo-oligosaccharides and inulin impact inter-individual variation on microbial metabolism and composition, which immunomodulates human cells. J Agric Food Chem 66(5):1121–1130

    Article  PubMed  CAS  Google Scholar 

  • Van den Nieuwboer M, Brummer RJ, Guarner F, Morelli L, Cabana M, Claassen E (2015) The administration of probiotics and synbiotics in immune compromised adults: is it safe? Benef Microbes 6(1):3–17

    Article  PubMed  Google Scholar 

  • Vanhoutte T, De Preter V, De Brandt E, Verbeke K, Swings J, Huys G (2006) Molecular monitoring of the fecal microbiota of healthy human subjects during administration of lactulose and Saccharomyces boulardii. Appl Environ Microbiol 72(9):5990–5997

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vulevic J, Juric A, Walton GE, Claus SP, Tzortzis G, Toward RE, Gibson GR (2015) Influence of galacto-oligosaccharide mixture (B-GOS) on gut microbiota, immune parameters and metabonomics in elderly persons. Br J Nutr 114(4):586–595

    Article  CAS  PubMed  Google Scholar 

  • Webb GP, Webb GP (2006) Dietary supplements and functional foods. Blackwell, pp 210–215

    Book  Google Scholar 

  • West NP, Horn PL, Barrett S, Warren HS, Lehtinen MJ, Koerbin G, Brun M, Pyne DB, Lahtinen SJ, Fricker PA, Cripps AW (2014) Supplementation with a single and double strain probiotic on the innate immune system for respiratory illness. e-SPEN J 9(5):e178–e184

    Article  Google Scholar 

  • Whisner CM, Martin BR, Nakatsu CH, Story JA, MacDonald-Clarke CJ, McCabe LD, McCabe GP, Weaver CM (2016) Soluble corn fiber increases calcium absorption associated with shifts in the gut microbiome: a randomized dose-response trial in free-living pubertal females. J Nutr 146(7):1298–1306

    Article  CAS  PubMed  Google Scholar 

  • Wildman RE (ed) (2016) Handbook of nutraceuticals and functional foods. CRC

    Google Scholar 

  • World Health Organization, Food and Agricultural Organization of the United Nations (2006) Probiotics in food: health and nutritional properties and guidelines for evaluation. Food and Nutrition. World Health Organization, Rome

    Google Scholar 

  • Wu HJ, Wu E (2012) The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes 3(1):4–14

    Article  PubMed  PubMed Central  Google Scholar 

  • Wu T, Grootaert C, Pitart J, Vidovic NK, Kamiloglu S, Possemiers S, Glibetic M, Smagghe G, Raes K, Van de Wiele T, Van Camp J (2018) Aronia (Aronia melanocarpa) polyphenols modulate the microbial community in a Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and decrease secretion of proinflammatory markers in a Caco-2/endothelial cell coculture model. Mol Nutr Food Res 62(22):1800607

    Article  CAS  Google Scholar 

  • Xavier-Santos D, Lima ED, Simão ANC, Bedani R, Saad SMI (2018) Effect of the consumption of a synbiotic diet mousse containing Lactobacillus acidophilus La-5 by individuals with metabolic syndrome: a randomized controlled trial. J Funct Foods 41:55–61

    Article  CAS  Google Scholar 

  • Yahfoufi N, Mallet JF, Graham E, Matar C (2018) Role of probiotics and prebiotics in immunomodulation. Curr Opin Food Sci 20:82–91

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kavita Pandey .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Pandey, K., Modi, A. (2022). Implications of Probiotics and Prebiotics on Immune Functions. In: Behera, K.K., Bist, R., Mohanty, S., Bhattacharya, M. (eds) Prebiotics, Probiotics and Nutraceuticals. Springer, Singapore. https://doi.org/10.1007/978-981-16-8990-1_10

Download citation

Publish with us

Policies and ethics

Navigation