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Biomarkers of Oxidative Stress-Induced Cancer
The importance of oxidative process and underlying dangers is always undermined in normal physiology as evolutionary mechanism ensured availability...
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Dopamine and Gastrointestinal Motility
Dopamine (DA) plays an important role in regulating gastrointestinal (GI) motility function, from the esophagus to the colon. In this chapter, we...
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Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome
Purpose of ReviewThe Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that responds to a variety of structurally diverse...
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Patients with Chromosome 11q Deletions Are Characterized by Inborn Errors of Immunity Involving both B and T Lymphocytes
Disorders of the long arm of chromosome 11 (11q) are rare and involve various chromosomal regions. Patients with 11q disorders, including Jacobsen...
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Why do ‘OFF’ periods still occur during continuous drug delivery in Parkinson’s disease?
Continuous drug delivery (CDD) is used in moderately advanced and late-stage Parkinson’s disease (PD) to control motor and non-motor fluctuations...
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White matter pathology in alzheimer’s transgenic mice with chronic exposure to low-level ambient fine particulate matter
BackgroundAir pollution, especially fine particulate matter (PM), can cause brain damage, cognitive decline, and an increased risk of...
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Melatonin secretion and sleep disorders in patients with spinal cord injuries
Study designProspective observational study.
ObjectivesTo evaluate melatonin secretion, daytime sleepiness and sleep disorders in patients with...
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HIV peripheral neuropathy‐related degeneration of white matter tracts to sensorimotor cortex
Human immunodeficiency virus-associated distal sensory polyneuropathy (HIV-DSP) affects up to 50% of people with HIV and is associated with...
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Non-invasive vagus nerve stimulation: the future of inflammatory bowel disease treatment?
The vagus nerve regulates inflammation and cytokine release through the inflammatory reflex. Recent pilot clinical trials using implantable...
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In Vitro and In Silico ADME Prediction
Pharmacokinetic issues have been identified as a major cause for the attrition of new chemical entities in drug discovery. High development costs and...
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Drug Repurposing in Gastric Cancer: Current Status and Future Perspectives
Gastric cancer remains an important contributor to the global cancer burden ranking the 5th most common and the 4th most deadly cancer, according to...
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First molecular description of Macracanthorhynchus hirudinaceus in wild boars from Italy with pathomorphological and epidemiological insights
Macracanthorhynchus hirudinaceus is a zoonotic parasite affecting suids worldwide which are the definitive hosts for this helminth species. Macracantho...
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Essential concepts are missing: Foreign DNA in food invades the organisms’ cells and can lead to stochastic epigenetic alterations with a wide range of possible pathogenetic consequences
In this article, a new concept for general pathogenesis has been proposed. Advances in molecular genetics have led to the realization that essential...
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Current Spectrum of Infections in Patients with X-Linked Agammaglobulinemia
Outcome of patients with X-linked agammaglobulinemia (XLA) has improved with the widespread use of immunoglobulin replacement therapy (IgRT). There...
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Development of In Vitro Dissolution Testing Methods to Simulate Fed Conditions for Immediate Release Solid Oral Dosage Forms
In vitro dissolution testing is widely used to mimic and predict in vivo performance of oral drug products in the gastrointestinal (GI) tract. This...
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The Inhibitory Activity of Lactobacillus plantarum Supernatant against Enterobacteria, Campylobacter, and Tumor Cells
Cell-free supernatant of Lactobacillus plantarum exhibit a strong antimicrobial effect against a number of pathogenic enterobacteria ( E. coli , Shigella...
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Clinical Validation of a Primary Antibody Deficiency Screening Algorithm for Primary Care
PurposeThe diagnostic delay of primary antibody deficiencies (PADs) is associated with increased morbidity, mortality, and healthcare costs....
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Nano Drug Delivery Approaches for Lymphatic Filariasis Therapeutics
Engineering and crafting of a functional system at the molecular level is coined as nanotechnology, ranging in the scale of 0.1–100 nm. This range of...
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Prevalence and risk factors associated with cat parasites in Italy: a multicenter study
BackgroundParasites that infect cats include protozoa, helminths and arthropods, many of which are transmissible to humans. Effective control relies...
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The Role of Gram-Negative Bacteria in Urinary Tract Infections: Current Concepts and Therapeutic Options
Urinary tract infections (UTIs) are some of the most common infections in human medicine worldwide, recognized as an important public health concern...