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TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming
Classic major histocompatibility complex class I (MHC-I) presentation relies on shuttling cytosolic peptides into the endoplasmic reticulum (ER) by...
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Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome
Functional perturbations of the cohesin complex with subsequent changes in chromatin structure and replication are reported in a multitude of cancers...
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Increased blood draws for ultrasensitive ctDNA and CTCs detection in early breast cancer patients
Early breast cancer patients often experience relapse due to residual disease after treatment. Liquid biopsy is a methodology capable of detecting...
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Efficacy of an antimicrobial stewardship intervention for early adaptation of antibiotic therapy in high-risk neutropenic patients
BackgroundThe 4th European Conference on Infections in Leukemia recommends early adaptation of empirical antibiotic therapy (EAT) for febrile...
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Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers
The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of...
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Liver transplantation as a treatment for Wilson’s disease with neurological presentation: a systematic literature review
IntroductionWilson’s disease (WD) is a potentially treatable, genetic disorder of copper metabolism, with survival similar to healthy populations if...
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How to Structure a Scientific Article, Conference Poster and Presentation
The main aim of any research endeavor is to disseminate research findings among the scientific community and enrich scientific knowledge. The two...
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A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue
Following acute injury, stromal cells promote tissue regeneration by a diversity of mechanisms. Time-resolved single-cell RNA sequencing of muscle...
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Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion
Immune checkpoint blockade, which blocks inhibitory signals of T cell activation, has shown tremendous success in treating cancer, although success...
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Integrative analysis reveals early epigenetic alterations in high-grade serous ovarian carcinomas
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological malignancy. To date, the profiles of gene mutations and copy number...
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Deficient Novelty Detection and Encoding in Early Alzheimer’s Disease: An ERP Study
Patients with early Alzheimer’s disease (AD) have difficulty in learning new information and in detecting novel stimuli. The underlying physiological...
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Clinical study of thoracoscopic assisted different surgical approaches for early thymoma: a meta-analysis
ObjectiveThe efficacy and safety of subxiphoid thoracoscopic thymectomy (SVATS) for early thymoma are unknown. The purposes of this meta-analysis...
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High-altitude exposure leads to increased modularity of brain functional network with the increased occupation of attention resources in early processing of visual working memory
Working memory is a complex cognitive system that temporarily maintains purpose-relevant information during human cognition performance. Working...
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Modelled mortality benefits of multi-cancer early detection screening in England
BackgroundScreening programmes utilising blood-based multi-cancer early detection (MCED) tests, which can detect a shared cancer signal from any site...
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A 3-year natural history of orthostatic blood pressure dysregulation in early Parkinson’s disease
In Parkinson’s disease (PD), cardiovascular dysautonomia accumulates with disease progression, but studies are lacking on the natural history behind...
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Effects of Ovariectomy on Learning in Rats in Health and after Early Proinflammatory Stress
We report here studies on the effects of ovariectomy (OE) in females performed at age 35 days on the development and extinction of a conditioned fear...
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Early detection of pancreatic cancer by liquid biopsy “PANLIPSY”: a french nation-wide study project
BackgroundPancreatic cancer, predominantly characterized by ductal adenocarcinoma (PDAC) accounts for 90% of cases and is the fourth leading cause of...
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Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach
BackgroundThe earliest pathological features of Alzheimer’s disease (AD) appear decades before the clinical symptoms. The pathology affects the brain...
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Potential Biomarkers for Early Diagnosis of Alzheimer’s Disease and Primary Open-Angle Glaucoma
Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the clinical picture, in addition to cognitive and behavioral disorders,...
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Impact of the Sars-Cov-2 outbreak on the initial clinical presentation of new solid cancer diagnoses: a systematic review and meta-analysis
BackgroundThe COVID-19 pandemic might have delayed cancer diagnosis and management. The aim of this systematic review was to compare the initial...
