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The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach?
Epilepsy, a prevalent neurological disease characterized by spontaneous recurrent seizures (SRS), is often refractory to treatment with anti-seizure...
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Lijst van Geneesmiddelen
Het ureum bevat een niet-radioactief stabiel koolstofisotoop (koolstof 13). Toegepast als ademtest bij de in-vivo diagnostiek van het vermoeden van...
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Antiepileptic Activity
Epilepsy is a disease of high prevalence, known for thousands of years as “morbus sacer.” In spite of intensive investigations, the pathophysiology...
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Synthesis, anticonvulsant activity and QSAR studies of some new pyrazolyl pyridines
Twenty-one new 3,5-bipyridinyl-1 H -pyrazole derivatives (pyrazolyl pyridines) have been synthesized and evaluated for their anticonvulsant activity in...
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Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs
In recent years, synaptic vesicle protein 2A (SV2A) has become an attractive protein to study due to its important role in epilepsy. This protein is...
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Levetiracetam Prevents Perforin Mediated Neuronal Injury Induced by Acute Cerebral Ischemia Reperfusion
The purpose of this study is to explore the neuroprotection mechanism of levetiracetam (LEV) with acute focal cerebral ischemia-reperfusion (I/P)...
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Synthesis and anticonvulsant activity of new N-phenyl-2-(4-phenylpiperazin-1-yl)acetamide derivatives
Twenty-two new N -phenyl-2-(4-phenylpiperazin-1-yl)acetamide derivatives have been synthesized and evaluated for their anticonvulsant activity in...
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Synthesis, biological evaluation and molecular docking studies of thiazole-based pyrrolidinones and isoindolinediones as anticonvulsant agents
AbstractA series of new 1-(thiazol-2-yl)pyrrolidin-2-one 5a – m and 2-(thiazol-2-yl)isoindoline-1,3-dione 6a – n derivatives were synthesized and...
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Network meta-analyses of antiepileptic drug efficacy and tolerability in drug-resistant focal epilepsies: a clinical perspective
PurposeNetwork meta-analysis (NMA) is a new technique that allows multiple treatment comparisons and provides estimates of effect sizes for all...
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Treatment of Myoclonus
Myoclonus creates significant disability for patients. This symptom or sign can have many different etiologies, presentations, and pathophysiological...
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Effects of Marketed Antiepileptic Drugs and Placebo in the Human Photosensitivity Screening Protocol
A study of epilepsy patients with a reproducible range of photoparoxysmal responses (PPR) (epileptiform discharges evoked by flashing lights) has...
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Expression of SV2 isoforms during rodent brain development
BackgroundSV2A, SV2B and SV2C are synaptic vesicle proteins that are structurally related to members of the major facilitator superfamily (MFS). The...
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The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments
A major goal of contemporary epilepsy research is the identification of therapies to prevent the development of recurrent seizures in individuals at...
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New avenues for anti-epileptic drug discovery and development
Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications fail to control seizures in 20–30% of patients....
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γ-Amino butyric acid analogs as novel potent GABA-AT inhibitors: molecular docking, synthesis, and biological evaluation
A new series, of γ-amino butyric acid analogs were designed and synthesized as novel potent GABA-AT inhibitors. A structure–activity relationship...
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Weight-Reducing Side Effects of the Antiepileptic Agents Topiramate and Zonisamide
Drug-induced weight alteration can be a serious side effect that applies to several therapeutic agents and must be referred to in the respective...
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Key factors in the discovery and development of new antiepileptic drugs
Since the early 1990s, many new antiepileptic drugs (AEDs) that offer appreciable advantages in terms of their favourable pharmacokinetics, improved...
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New Antiepileptic Drugs in Neuropsychiatric Disorders – Basic Mechanisms Related to Clinical Efficacy
This chapter will cover basic mechanisms of action and correlates to clinical efficacy of recent advances of new antiepileptic drugs (AEDs) in...