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Natural Products: Exploring Potential Against SARS CoV2
As all pandemics reorient the world not only in the health sector, COVID-19 also had caused major havoc even in the socioeconomic sector. Identifying...
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Bioinformatics driven discovery of small molecule compounds that modulate the FOXM1 and PPARA pathway activities in breast cancer
Our previous studies demonstrated that the FOXM1 pathway is upregulated and the PPARA pathway downregulated in breast cancer (BC), and especially in...
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Small Molecule Screening Discovers Compounds that Reduce FMRpolyG Protein Aggregates and Splicing Defect Toxicity in Fragile X-Associated Tremor/Ataxia Syndrome
Expansion of CGG trinucleotide repeats in 5′ untranslated region of the FMR1 gene is the causative mutation of neurological diseases such as fragile...
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Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer
Intensive research in the field of cancer biology has revealed unique methods of communication between cells through extracellular vesicles called...
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Hemozoin: a Complex Molecule with Complex Activities
Purpose of ReviewMalaria is a disease caused by parasites that reside in host red blood cells and use hemoglobin as a nutrient source. Heme released...
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Natural Immunomodulatory Agents as a Complementary Therapy for Poxviruses
PoxvirusesPoxviruses target innate immunity mediators such as tumor necrosis factors, interleukins, interferons, complement, and chemokines. It also...
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Cultivation of Corn Silk: Remunerative Venture for Medicinal Boon and Antimicrobial Therapies
Corn silk (CS; Stigma maydis) has been used traditionally by Chinese and Native American medicine for the treatment of a variety of illnesses for...
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The Potential Role of Bioactive Plant-Based Polyphenolic Compounds and Their Delivery Systems—as a Promising Opportunity for a New Therapeutic Solution for Acute and Chronic Wound Healing
Purpose of ReviewPlant-based polyphenolic compounds are natural by-products known as plant secondary metabolites, which have significant utilities in...
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Cardiovascular Therapeutics from Natural Sources
Cardiovascular diseases (CVDs) are a group of heart and blood vessel disorder. It is a persistent global health challenge, being the number one cause...
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Efficacy of Synthetic Organic Molecule Inhibitors of TRAF2 and NCK-Interacting Kinase (TNIK) Against Colorectal Cancer
Kinases are widely regarded as the principal biocatalysts that drive many anomalies in cancer. Tumorigenesis is characterized by proliferation of...
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Peptidomimetics in Medicinal Chemistry: The Art of Transforming Peptides to Drugs
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or...
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Efficacy of Synthetic Organic Molecule Inhibitors of TRAF2 and NCK-Interacting Kinase (TNIK) Against Colorectal Cancer
Kinases are widely regarded as the principal biocatalysts that drive many anomalies in cancer. Tumorigenesis is characterized by proliferation of...
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Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients
Human infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and there is no cure...
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Identification of bio-active secondary metabolites from Actinobacteria as potential drug targets against Porphyromonas gingivalis in oral squamous cell carcinoma using molecular docking and dynamics study
Chronic periodontitis caused by the bacteria Porphyromonas gingivalis is thought to be a risk factor for the advancement of oral squamous cell...
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Plant Disease Management by Bioactive Natural Products
The expansion in population and economies leads to development of new methods of agriculture to increase the productivity and meet the demand....
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Macrophage-Targeted Chemotherapy for Tuberculosis
The emergence and frequent occurrence of multidrug-resistant strains of Mycobacterium tuberculosis (the causative pathogen for the deadly infectious...
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Effect of Glycyrrhetic Acid Derivatives on Regulation of Thymocyte Volume
We studied the effects of glycyrrhetinic acid (bioactive aglycone of glycyrrhizin) and its ester derivatives at positions C-3 and C-30 on the cell...
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Meta analysis of bioactive compounds, miRNA, siRNA and cell death regulators as sensitizers to doxorubicin induced chemoresistance
Cancer has presented to be the most challenging disease, contributing to one in six mortalities worldwide. The current treatment regimen involves...
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Uncovering the Desert Fungal Enigma: An Attractive Resource for Biopharmaceuticals
Fungi reside everywhere on the earth, from the Arctic to the tropics. Fungi are described as an exceptionally capable organism living in extremely...
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Docking simulation and ADMET prediction based investigation on the phytochemical constituents of Noni (Morinda citrifolia) fruit as a potential anticancer drug
Morinda citrifolia is a traditional plant used in Asian and African countries for its wide nutraceutical and therapeutic effects for the treatment of...
