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HIV
Acquired immunodeficiency syndrome (AIDS) is a life-threatening chronic condition caused by the human immunodeficiency virus (HIV). HIV infection...
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Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis
BackgroundIn human immunodeficiency virus-1 (HIV-1) infection, activation of astrocytes induces imbalance in physiological functions due to perturbed...
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Addressing an HIV cure in LMIC
HIV-1 persists in infected individuals despite years of antiretroviral therapy (ART), due to the formation of a stable and long-lived latent viral...
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Macrophage Targeting for Therapy of HIV
HIV is a global threat, not only from today but for ages as nearly 25 million people have died due to this curse of nature and approximately 40...
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HIV-1 and HBV RNase H as Metal-Chelating Inhibitors: Discovery and Medicinal Chemistry Strategies
Human immunodeficiency viruses (HIV) andHuman Immunodeficiency virus (HIV) hepatitis B viruses (HBV) areHepatitis B virus (HBV) highly pathogenic...
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MicroRNAs and long non-coding RNAs during transcriptional regulation and latency of HIV and HTLV
Human immunodeficiency virus (HIV) and human T cell leukemia virus (HTLV) have replicative and latent stages of infection. The status of the viruses...
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Herpesviruses
The herpesviruses are large, enveloped DNA viruses, measuring 120–200 nm in diameter. They exhibit many common features, such as similar morphology...
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Virtual memory CD8+ T cells restrain the viral reservoir in HIV-1-infected patients with antiretroviral therapy through derepressing KIR-mediated inhibition
The viral reservoir is the major hurdle in develo** and establishing an HIV cure. Understanding factors affecting the size and decay of this...
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Purinergic signaling in the battlefield of viral infections
Purinergic signaling has been associated with immune defenses against pathogens such as bacteria, protozoa, fungi, and viruses, acting as a sentinel...
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Inhalation Therapy in Pulmonary Tuberculosis
Tuberculosis (TB) is a historical disease that can trace its impact on humanityHumanity back in time thousands of years. A bacterial...
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Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates
In this study, we demonstrate the safety and utility of CRISPR-Cas9 gene editing technology for in vivo editing of proviral DNA in ART-treated,...
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New GMP manufacturing processes to obtain thermostable HIV-1 gp41 virosomes under solid forms for various mucosal vaccination routes
The main objective of the MACIVIVA European consortium was to develop new Good Manufacturing Practice pilot lines for manufacturing thermostable...
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Droplet-microfluidics-assisted sequencing of HIV proviruses and their integration sites in cells from people on antiretroviral therapy
The human immunodeficiency virus (HIV) integrates its genome into that of infected cells and may enter an inactive state of reversible latency that...
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A CCR5+ memory subset within HIV-1-infected primary resting CD4+ T cells is permissive for replication-competent, latently infected viruses in vitro
ObjectiveResting CD4 + T cells are major reservoirs of latent HIV-1 infection, and may be formed during the early phase of the infection. Although...
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Efficacy and safety of lenalidomide in HIV-associated cryptococcal meningitis patients with persistent intracranial inflammation: an open-label, single-arm, prospective interventional study
BackgroundPatients with human immunodeficiency virus-associated cryptococcal meningitis (HIV-CM) have persistent intracranial inflammation despite...
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A comparative analysis of unintegrated HIV-1 DNA measurement as a potential biomarker of the cellular reservoir in the blood of patients controlling and non-controlling viral replication
BackgroundThe persistence of HIV-1 in reservoir cells is one of the major obstacles to eradicating the virus in infected individuals receiving...
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NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal
BackgroundCurrent efforts towards HIV-1 eradication focus on the reactivation and elimination of the latent viral reservoir, so-called shock and kill...
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Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure
Following reverse transcription, HIV viral DNA is integrated into host cell genomes and establishes a stable latent infection, which has posed a...
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Generation of Anti-HIV CAR-T Cells for Preclinical Research
The inability of people living with HIV (PLWH) to eradicate human immunodeficiency virus (HIV) infection is due in part to the inadequate...
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Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaques
Develo** an intervention that results in virologic control following discontinuation of antiretroviral therapy (ART) is a major objective of HIV-1...
