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Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons
Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the modulation of pain. As chronic pain conditions are associated...
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Nicotinic and Muscarinic Acetylcholine Receptor Agonists Counteract Cognitive Impairment in a Rat Model of Doxorubicin-Induced Chemobrain via Attenuation of Multiple Programmed Cell Death Pathways
Chemotherapy causes undesirable long-term neurological sequelae, chemotherapy-induced cognitive impairment (CICI), or chemobrain in cancer survivors....
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Cholinergic Signaling Dynamics and Cognitive Control of Attention
The central cholinergic system is one of the most important modulator neurotransmitter system implicated in diverse behavioral processes. Activation...
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Nicotine promotes the utility of short-term memory during visual search in macaque monkeys
RationaleThe central cholinergic system is a major therapeutic target for restoring cognitive functions. Although manipulation of cholinergic...
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Effects of Prolonged Seizures on Basal Forebrain Cholinergic Neurons: Evidence and Potential Clinical Relevance
Seizures originating from limbic structures, especially when prolonged for several minutes/hours up to status epilepticus (SE), can cause specific...
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Impact of Prenatal Nicotine Exposure on Placental Function and Respiratory Neural Network Development
Smoking during pregnancy is associated with multiple undesirable outcomes in infants, such as low birth weight, increased neonatal morbidity and...
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Protective effect of α7 nicotinic acetylcholine receptor activation on experimental colitis and its mechanism
BackgroundInflammatory bowel disease (IBD) is a common chronic remitting disease with no satisfactory treatment. The aim of this study was to...
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Pathophysiology and Management Approaches in Alzheimer’s Disease
Alzheimer’s disease is recognized as a progressive multifarious neurodegenerative disorder that is pathologically characterized by the deposition of...
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Targeting the cholinergic system in Parkinson’s disease
Motor control in the striatum is an orchestra played by various neuronal populations. Loss of harmony due to dopamine deficiency is considered the...
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Potential antiproliferative and apoptotic effects of pilocarpine combined with TNF alpha in chronic myeloid leukemia cells
Pilocarpine is a selective M 1 /M 3 agonist of muscarinic acetylcholine receptor subtypes. Muscarinic acetylcholine receptors are G protein-coupled...
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Mechanisms of AMPA Receptor Inhibition by Diminazene
Diminazene is an anti-infection agent for animals and is a member of the diarylamidine group. This study reports the first detection of its...
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Cholinergic Receptors and Addiction
Human behavior can be controlled by physical or psychological dependencies associated with addiction. One of the most insidious addictions in our...
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DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats
The brainstem-based pedunculopontine nucleus (PPN) traditionally associates with motor function, but undergoes extensive degeneration during...
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A Review of the Cholinergic System and Therapeutic Approaches to Treat Brain Disorders
Since its identification over a hundred years ago, the neurotransmitter acetylcholine (ACh) has proven to play an essential role in supporting many...
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The Effect of Donepezil Hydrochloride in the Twitcher Mouse Model of Krabbe Disease
Krabbe disease (KD) is a rare demyelinating disorder characterized by demyelination caused by mutations in the GALC gene, resulting in toxic...
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GTS-21, an α7nAChR agonist, increases pulmonary bacterial clearance in mice by restoring hyperoxia-compromised macrophage function
BackgroundMechanical ventilation, in combination with supraphysiological concentrations of oxygen (i.e., hyperoxia), is routinely used to treat...
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Noninvasive ultrasound stimulation to treat myocarditis through splenic neuro-immune regulation
BackgroundThe cholinergic anti-inflammatory pathway (CAP) has been widely studied to modulate the immune response. Current stimulating strategies are...
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Effects of the cannabinoid receptor agonist CP-55,940 on incentive salience attribution
RationalePavlovian conditioned approach paradigms are used to characterize the nature of motivational behaviors in response to stimuli as either...
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Additive effects of intravenous and intravesical application of vibegron, a β3-adrenoceptor agonist, on bladder function in rats with bladder overactivity
To examine the effects of intravenous and intravesical application of vibegron, a new β 3 -adrenoceptor (β 3 -AR) agonist, on bladder function in rats...
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3D bioprinting patient-derived induced pluripotent stem cell models of Alzheimer’s disease using a smart bioink
BackgroundAlzheimer’s disease (AD), a progressive neurodegenerative disorder, is becoming increasingly prevalent as our population ages. It is...
