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FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression
BackgroundInvasion and metastasis are the main causes of unfavourable prognosis in patients diagnosed with bladder cancer. The efficacy of...
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mTOR inhibition abrogates human mammary stem cells and early breast cancer progression markers
BackgroundMammary physiology is distinguished in containing adult stem/progenitor cells that are actively amending the breast tissue throughout the...
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MicroRNA-98: the multifaceted regulator in human cancer progression and therapy
MicroRNA-98 ( miR-98 ) stands as an important molecule in the intricate landscape of oncology. As a subset of microRNAs, these small non-coding RNAs...
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Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2 macrophages
Immunosuppressive tumor microenvironment (TME) contributes to tumor progression and causes major obstacles for cancer therapy. Phosphoglycerate...
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PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression
BackgroundTriple-negative breast cancer (TNBC) remains the most challenging subtype of breast cancer and lacks definite treatment targets. Aerobic...
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TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression
BackgroundAs a novel necrosis manner, ferroptosis has been increasingly reported to play a role in tumor progression and treatment, however, the...
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Deciphering the molecular landscape: evolutionary progression from gynecomastia to aggressive male breast cancer
BackgroundGynecomastia denotes the benign proliferation of glandular breast tissue and stands as a recognized risk factor for male breast cancer....
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Effects of RNA methylation on Tumor angiogenesis and cancer progression
Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one of the most common modifications and is widely...
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A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC–OXPHOS axis
BackgroundOvarian cancer (OC) is the most lethal malignant gynecological tumor type for which limited therapeutic targets and drugs are available....
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GRB7 plays a promoting role in the progression of gastric cancer
BackgroundGastric cancer is a clinically common tumor, showing an upward trend of both incidence and mortality. GRB7 has been identified as a vital...
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Discordance between GCIG CA-125 progression and RECIST progression in the CALYPSO trial of patients with platinum-sensitive recurrent ovarian cancer
BackgroundCA-125 alone is widely used to diagnose progressive disease (PD) in platinum-sensitive recurrent ovarian cancer (PSROC) on chemotherapy....
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The functional role of P2 purinergic receptors in the progression of gastric cancer
Studies have confirmed that P2 purinergic receptors (P2X receptors and P2Y receptors) expressed in gastric cancer (GC) cells and GC tissues and...
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METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression
BackgroundGlycolysis is the key hallmark of cancer and maintains malignant tumor initiation and progression. The role of N6-methyladenosine (m6A)...
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Early-Stage Progression of Breast Cancer
Breast cancer consists of group of molecularly heterogenous disease in which breast cells start growing in a prolific way. Globally, breast cancer is...
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CDCA5 accelerates progression of breast cancer by promoting the binding of E2F1 and FOXM1
BackgroundBreast cancer is one of the most common malignant tumors in women. Cell division cycle associated 5 (CDCA5), a master regulator of sister...
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SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression
BackgroundPancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer mortality in both males...
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Role of Cancer-Associated Adipocytes in the Progression of Breast Cancer
Breast cancer is a malignancy which is characterized with high invasion, metastasis, and recurrence rate. The tumor microenvironment is a key player...
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Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20
BackgroundThe repurposing of FDA-approved drugs for anti-cancer therapies is appealing due to their established safety profiles and pharmacokinetic...
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EYA4 promotes breast cancer progression and metastasis through its role in replication stress avoidance
The Eyes Absent (EYA) family of proteins is an atypical group of four dual-functioning protein phosphatases (PP), which have been linked to many...
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FGFR4-driven plasticity in breast cancer progression and resistance to therapy
Breast cancer (BCa) is a complex and heterogeneous disease, with different intrinsic molecular subtypes that have distinct clinical outcomes and...
