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Neuroprotective effects of chitosan nanoparticles loaded with niruriflavone in an aluminium chloride-induced Alzheimer’s disease rat model
ObjectivesAluminium (Al) is also a popular neurotoxin that accelerates oxidative damage to biomolecules, which is correlated to the aetiology of...
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Neuroprotective Effect of Vitamin D on Behavioral and Oxidative Parameters of Male and Female Adult Wistar Rats Exposed to Mancozeb (manganese/zinc ethylene bis-dithiocarbamate)
The constant exposure of rural workers to pesticides is a serious public health problem. Mancozeb (MZ) is a pesticide linked to hormonal,...
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Acute and sub-chronic toxicity studies of aqueous bark extract of Detarium microcarpum guill. and perr in albinos wistar rat
ObjectiveThis work aimed to evaluate the acute and sub-chronic toxicity of the aqueous bark extract of Detarium microcarpum ( D. microcarpum ),...
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Simultaneous Exposure to Noise and Toluene Induces Oxidative and Inflammatory Damage in the Heart of Wistar Rats: Therapeutic Potential of Olea europaea L. Leaf Extract
Workers in occupational settings often face simultaneous exposure to multiple risk factors, including noise and chemicals. This study aimed to...
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The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models
ObjectivesNLX-101 and NLX-204 are highly selective serotonin 5-HT 1A ‘biased’ agonists, displaying potent and efficacious...
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Sub-acute toxicity study of the aqueous extract from leaves and flowers of Acmella caulirhiza on female albino Wistar rats
ObjectAcmella caulirhiza is a medicinal plant traditionally widely used in Cameroon for the management of several pathologies, hence the need for...
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In diabetic male Wistar rats, quercetin-conjugated superparamagnetic iron oxide nanoparticles have an effect on the SIRT1/p66Shc-mediated pathway related to cognitive impairment
BackgroundQuercetin (QC) possesses a variety of health-promoting effects in pure and in conjugation with nanoparticles. Since the mRNA-SIRT1/p66Shc...
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Modulatory effect of Justicia secunda leaf extract on hematological status, lipid profile, liver function and oxidative stress in Wistar rats
Justicia secunda is a therapeutic plant with acclaimed beneficial health effects including blood-boosting potential. However, scientific evidence...
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An evaluation of the antioxidant capacities of Dillenia excelsa extracts and its wound healing activity in Wistar rats
Dillenia excelsa , a medicinal plant found in Brunei Darussalam, has been traditionally used by locals for treating various ailments. The present...
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Profiling GABA(A) Receptor Subunit Expression in the Hippocampus of PMDD Rat Models Based on TCM Theories
γ-Aminobutyric acid type A receptors (GABAARs) play an important role in cognitive and emotional regulation and are related to the hippocampus....
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Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2
Androgen excess and metabolic abnormality largely contribute to the pathogenesis of polycystic ovarian syndrome (PCOS), which primarily precipitates...
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Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer’s disease activity in Wister rat model
Lately, interest surrounding the utilization of plant-derived compounds as a viable beneficial approach for treating Alzheimer’s disease (AD) has...
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Exploring the role of Aquaporins (AQPs) in LPS induced systemic inflammation and the ameliorative effect of Garcinia in male Wistar rat
The Aquaporins (AQPs) could prove to be striking targets of inflammation. The aim of this study was to study the involvement of AQPs and explore the...
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Postnatal GABAA Receptor Activation Alters Synaptic Plasticity and Cognition in Adult Wistar Rats
Early life alteration in the activity of gamma-aminobutyric acid (GABA) receptors is associated with long-lasting developmental effects on the brain...
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Differences in Changes in the Glutamate/GABA System Activity in the Rat Retina during Aging and the Development of Retinopathy at Nighttime and Daytime
Abstract —Age is a leading risk factor for the development of age-related macular degeneration (AMD), which is the cause of vision loss in the...
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Therapeutic Effects of Citral Nanoliposome on Parkinson’s Treatment in a Rat Model: Modulation via Neurochemical, Inflammatory and Antioxidant Pathways
AbstractParkinson’s disease is the most common neurodegenerative movement disorder, the pathogenesis of which is partly related with oxidant status...
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Promising effect of Geranium robertianum L. leaves and Aloe vera gel powder on Aspirin®-induced gastric ulcers in Wistar rats: anxiolytic behavioural effect, antioxidant activity, and protective pathways
BackgroundMany drugs have been restricted in the treatment of gastric ulcers (GU). So, herbal medicines are now in great demand for their better...
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Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats
BackgroundDatura stramonium L. (Solanaceae) is used traditionally in west Africa to treat asthma, epilepsy, rheumatoid arthritis, filariasis...
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Effects of reversible SERCA inhibition on catecholamine exocytosis and intracellular [Ca2+] signaling in chromaffin cells from normotensive Wistar Kyoto rats and spontaneously hypertensive rats
Intracellular Ca 2+ ([Ca 2+ ]i) signaling and catecholamine (CA) exocytosis from adrenal chromaffin cells (CCs) differ between mammalian species. These...
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Diosgenin, a steroidal sapogenin, arrests arthritis through modulation of inflammatory cytokines and oxidative stress biomarkers in Wistar rats
Diosgenin (DGN) is a well-known steroidal sapogenin that is obtained from the hydrolysis of dioscin. The current research aimed to explore the...
