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Tau Accumulation in the Spinal Cord Contributes to Chronic Inflammatory Pain by Upregulation of IL-1β and BDNF
Microtubule-associated protein Tau is responsible for the stabilization of neuronal microtubules under normal physiological conditions. Much...
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Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons
Our understanding of the biological functions of the tau protein now includes its role as a scaffolding protein involved in signaling regulation,...
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Cytomegalovirus infection induces Alzheimer’s disease-associated alterations in tau
Alzheimer’s disease (AD) manifests with loss of neurons correlated with intercellular deposition of amyloid (amyloid plaques) and intracellular...
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Tau Toxicity in Neurodegeneration
Tau is a microtubule-associated protein widely distributed in the central nervous system (CNS). The main function of tau is to promote the assembly...
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Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology
BackgroundAntibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in...
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Tau interactome and RNA binding proteins in neurodegenerative diseases
Pathological tau aggregation is a primary neuropathological feature of many neurodegenerative diseases. Intriguingly, despite the common presence of...
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Sha** the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models
The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and...
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Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology
BackgroundGranulovacuolar degeneration bodies (GVBs) are intracellular vesicular structures that commonly accompany pathological tau accumulations in...
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Increase in wasteosomes (corpora amylacea) in frontotemporal lobar degeneration with specific detection of tau, TDP-43 and FUS pathology
Wasteosomes (or corpora amylacea) are polyglucosan bodies that appear in the human brain with aging and in some neurodegenerative diseases, and have...
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TDP-43 pathology is associated with increased tau burdens and seeding
BackgroundMost Alzheimer’s Disease (AD) cases also exhibit limbic predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC),...
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Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
Distinctive post-translational modifications (PTM) characterize tau inclusions found in tauopathy patients. Using detergent-insoluble tau isolated...
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Tau seeding in cases of multiple sclerosis
Relapsing remitting multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system that in many cases leads to...
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TGF-β1 signalling in Alzheimer’s pathology and cytoskeletal reorganization: a specialized Tau perspective
Microtubule-associated protein, Tau has been implicated in Alzheimer's disease for its detachment from microtubules and formation of insoluble...
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Serum phosphorylated tau protein 181 and neurofilament light chain in cognitively impaired heart failure patients
BackgroundChronic heart failure (HF) is known to increase the risk of develo** Alzheimer’s dementia significantly. Thus, detecting and preventing...
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Accurate digital quantification of tau pathology in progressive supranuclear palsy
The development of novel treatments for Progressive Supranuclear Palsy (PSP) is hindered by a knowledge gap of the impact of neurodegenerative...
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Pathological Impact of Tau Proteolytical Process on Neuronal and Mitochondrial Function: a Crucial Role in Alzheimer’s Disease
Tau protein plays a pivotal role in the central nervous system (CNS), participating in microtubule stability, axonal transport, and synaptic...
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Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer’s disease
The use of biomarker-led clinical trial designs has been transformative for investigating amyloid-targeting therapies for Alzheimer’s disease (AD)....
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Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells
In Alzheimer disease (AD), Tau, an axonal microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, accumulates, and...
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Role of Tau in Various Tauopathies, Treatment Approaches, and Emerging Role of Nanotechnology in Neurodegenerative Disorders
A few protein kinases and phosphatases regulate tau protein phosphorylation and an imbalance in their enzyme activity results in tau...
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Quantitative Measurement of Tau Aggregation in Genetically Modified Rats with Neurodegeneration
Animal models of neurodegenerative diseases have helped us to better understand the pathogenesis of neurodegenerative diseases. However, recent...