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Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke
Uric acid (UA) is an antioxidant with neuroprotective effects in experimental stroke models. Whether serum UA plays a role in hemorrhagic...
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The protective effects of protocatechuic acid against natural and chemical toxicants: cellular and molecular mechanisms
Protocatechuic acid (PCA) is a water-soluble polyphenol compound that is extracted from certain fruits and plants or obtained from glucose...
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Serum phosphorylated tau protein 181 and neurofilament light chain in cognitively impaired heart failure patients
BackgroundChronic heart failure (HF) is known to increase the risk of develo** Alzheimer’s dementia significantly. Thus, detecting and preventing...
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Population pharmacokinetics and dosage optimization of linezolid in Chinese older patients
PurposeTo assess the pharmacokinetics and pharmacodynamics of linezolid in a retrospective cohort of hospitalized Chinese older patients.
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Stevia extract safeguards rats from diabetic renal injury by mitigating markers of inflammation, oxidative stress, and apoptosis
ObjectiveThis study will figure out if stevia extract, a herb with anti-inflammatory and antioxidant characteristics, is effective in treating...
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Preoperative serum bilirubin is an independent prognostic factor for curatively resected esophageal squamous cell carcinoma
PurposeThis study examines prognostic value of preoperative serum bilirubin, including unconjugated bilirubin (UCB), conjugated bilirubin (CB), and...
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Association between serum albumin and 60-day mortality in Chinese Hakka patients with non-APL acute myeloid leukemia: a retrospective cohort study
BackgroundAcute myeloid leukemia (AML) is the main type of adult leukemia, and 60-day mortality is a vital clinical problem that doctors have to face...
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Label free quantitative proteomic profiling of serum samples of intellectually disabled young patients revealed dysregulation of complement coagulation and cholesterol cascade systems
Intellectual disability is a heterogeneous disorder, diagnosed using intelligence quotient (IQ) score criteria. Currently, no specific clinical test...
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Association of MPPED2 gene variant rs10767873 with kidney function and risk of cardiovascular disease in patients with hypertension
Changes in kidney function and the progression of chronic kidney disease (CKD) are associated with the risk of cardiovascular disease (CVD) and...
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Biomarkers of Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy
Neonatal hypoxic-ischemic encephalopathy (HIE) results from the disruption of cerebral oxygen delivery and is a major cause of disability worldwide....
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The ethanolic extract of Aframomum angustifolium seeds protects against tamoxifen-induced side effects in rats with breast cancer
Long-term use of tamoxifen (TAM) is associated with severe side effects. The present study aimed at evaluating the protective effect of the ethanolic...
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Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system
The objective of this study was to fabricate a novel drug delivery system using Soluplus® (polyvinyl caprolactam–polyvinyl acetate–polyethylene...
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Anti-hyperuricemic potential of caryophyllene from Syzygium aromaticum essential oil: SiO2-AgNO3-based column chromatography purification, antioxidant, and xanthine oxidase inhibitory activities
Xanthine oxidase is an enzyme that plays an essential role in the biosynthesis of uric acid. Inhibiting this enzyme can diminish the production of...
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Nonlinear relationship between serum uric acid and body mass index: a cross-sectional study of a general population in coastal China
BackgroundConflicting evidence exists on the relationship between body mass index (BMI) and serum uric acid (SUA). Therefore, we aimed to evaluate...
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In vitro and in vivo therapeutic antileishmanial potential of ellagic acid against Leishmania donovani in murine model
Parasite of genus Leishmania viz. L. donovani and L. infantum cause visceral leishmaniasis (VL) or Kala-azar, systemic disease with significant...
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Nifuroxazide attenuates indomethacin-induced renal injury by upregulating Nrf2/HO-1 and cytoglobin and suppressing NADPH-oxidase, NF-κB, and JAK-1/STAT3 signals
Indomethacin (INDO) is an NSAID with remarkable efficacy and widespread utilization for alleviating pain. Nevertheless, renal function impairment is...
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Sub-acute toxicity study of the aqueous extract from leaves and flowers of Acmella caulirhiza on female albino Wistar rats
ObjectAcmella caulirhiza is a medicinal plant traditionally widely used in Cameroon for the management of several pathologies, hence the need for...
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Uric acid pathway activation during respiratory virus infection promotes Th2 immune response via innate cytokine production and ILC2 accumulation
Respiratory syncytial virus (RSV) infects a majority of infants and can cause severe disease leading to increased risk to develop asthma later in...
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Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations
Uric acid, the end product of purine metabolism in humans, is crucial because of its anti-oxidant activity and a causal relationship with...
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HPRT1 Deficiency Induces Alteration of Mitochondrial Energy Metabolism in the Brain
Alterations in function of hypoxanthine guanine phosphoribosyl transferase (HPRT), one of the major enzymes involved in purine nucleotide exchange,...
