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MD-UNet: a medical image segmentation network based on mixed depthwise convolution
In the process of cancer diagnosis and treatment, accurate extraction of the lesion area helps the doctor to judge the condition. Currently, medical...
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Changes in brain rhythms and connectivity tracking fear acquisition and reversal
Fear conditioning is used to investigate the neural bases of threat and anxiety, and to understand their flexible modifications when the environment...
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NSMCE2, a novel super-enhancer-regulated gene, is linked to poor prognosis and therapy resistance in breast cancer
BackgroundDespite today’s advances in the treatment of cancer, breast cancer-related mortality remains high, in part due to the lack of effective...
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ECG Signal Quality Assessments of a Small Bipolar Single-Lead Wearable Patch Sensor
PurposeThere is an increasing clinical interest in the adoption of small single-lead wearable ECG sensors for continuous cardiac monitoring. The...
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TRPV4 Regulates Soman-Induced Status Epilepticus and Secondary Brain Injury via NMDA Receptor and NLRP3 Inflammasome
Nerve agents are used in civil wars and terrorist attacks, posing a threat to public safety. Acute exposure to nerve agents such as soman (GD) causes...
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Dopamine increases risky choice while D2 blockade shortens decision time
Dopamine is crucially involved in decision-making and overstimulation within dopaminergic pathways can lead to impulsive behaviour, including a...
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Identification on surrogating overall survival with progression-free survival of first-line immunochemotherapy in advanced esophageal squamous cell carcinoma—an exploration of surrogate endpoint
BackgroundOverall survival (OS) is the gold standard to assess novel therapeutics to treat cancer. However, to identify early efficacy and speed up...
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Poly(ethylene glycol)-b-poly(epsilon-caprolactone) nanoparticles as a platform for the improved oral delivery of cannabidiol
Cannabidiol (CBD), a non-psychoactive constituent of Cannabis , has proven neuroprotective, anti-inflammatory and antioxidant properties though his...
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Contextual and pure time coding for self and other in the hippocampus
Navigation and episodic memory depend critically on representing temporal sequences. Hippocampal ‘time cells’ form temporal sequences, but it is...
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Construction of SARS-CoV-2 spike-pseudotyped retroviral vector inducing syncytia formation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is handled in biosafety level 3 (BSL-3) facilities, whereas the antiviral screening of...
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QRS-T Angle as a Biomarker for LBBB Strict Diagnose
Currently, the diagnosis of left bundle branch block (LBBB) is based on the duration of the QRS complexes. However, aberrant QRS complexes,...
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Co-treatment of vitamin D supplementation with enriched environment improves synaptic plasticity and spatial learning and memory in aged rats
Rationale and objectiveEnvironmental enrichment (EE) has been shown in old rats to improve learning and memory. Vitamin D (VitD) has also been shown...
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Multifunctional IgG/IgM antibodies and cellular cytotoxicity are elicited by the full-length MSP1 SumayaVac-1 malaria vaccine
Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver stages and the disease-causing blood stages of the...
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S-EQUOL: a neuroprotective therapeutic for chronic neurocognitive impairments in pediatric HIV
Chronic neurocognitive impairments, commonly associated with pediatric human immunodeficiency virus type 1 (PHIV), are a detrimental consequence of...
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Preoperative chemoradiotherapy induces multiple pathways related to anti-tumour immunity in rectal cancer
BackgroundRectal cancer treated with preoperative radiotherapy (RT) provides an interesting model to study changes induced on cancer cell...
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The Design and Statistical Analysis of Randomized Pre-clinical Experiments
This chapter provides an introduction to the design of pre-clinical experiments using the “Completely randomized (CR)” and the “Randomized block...
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Methods for the Induction of Status Epilepticus and Temporal Lobe Epilepsy in Rodents: The Kainic Acid Model and the Pilocarpine Model
Status epilepticus (SE) and temporal lobe epilepsy (TLE) models are developed to understand the pathophysiology involved, discovering novel...
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Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome
Sézary syndrome (SS) is a heterogeneous leukemic subtype of cutaneous T-cell lymphoma (CTCL) with generalized erythroderma, lymphadenopathy, and a...
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House screening for malaria control: views and experiences of participants in the RooPfs trial
BackgroundThe housing stock of rural sub-Saharan Africa is changing rapidly. With millions of new homes required over the coming decades, there is an...
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Clinical spectrum of Transthyretin amyloidogenic mutations among diverse population origins
PurposeCoding mutations in the Transthyretin ( TTR ) gene cause a hereditary form of amyloidosis characterized by a complex genotype-phenotype...
