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SS18-SSX drives CREB activation in synovial sarcoma
PurposeSynovial sarcoma (SySa) is a rare soft tissue tumor characterized by a reciprocal t(X;18) translocation. The chimeric SS18-SSX fusion protein...
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Alternative antiviral approaches to combat influenza A virus
Influenza A (IAV) is a major human respiratory pathogen that contributes to a significant threat to health security, worldwide. Despite vaccinations...
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Combined analysis of the proteome and metabolome provides insight into microRNA-1174 function in Aedes aegypti mosquitoes
BackgroundPathogenic viruses can be transmitted by female Aedes aegypti ( Ae. aegypti ) mosquitoes during blood-meal acquisition from vertebrates....
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The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC
BackgroundMore than twenty years after its discovery, the role of the importin beta superfamily member Ran GTP-binding protein (RanBP) 17 is still...
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Characterizing genetic variation on the Z chromosome in Schistosoma japonicum reveals host-parasite co-evolution
BackgroundSchistosomiasis is a neglected tropical disease that afflicts millions of people worldwide; it is caused by Schistosoma, the only dioecious...
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RNAi Therapy for Dominant Muscular Dystrophies and Other Myopathies
Historically, the muscle gene therapy field has been primarily focused on replacing defective or missing genes underlying recessive disorders and has...
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Complete genome analysis of a novel narnavirus in sweet viburnum (Viburnum odoratissimum)
Trees and shrubs provide important ecological services. However, few studies have surveyed the virome in trees and shrubs. In this study, we...
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Fatty acid- and retinol-binding protein 6 does not control worm fatty acid content in Caenorhabditis elegans but might play a role in Haemonchus contortus parasitism
BackgroundNematodes have lost the ability to synthesise necessary lipids de novo and have complementally evolved the capacity to acquire fatty acids...
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Delivery of siRNA to Macrophages: Challenges and Opportunities
The discovery of the RNA interference (RNAi) pathway in 1998 and small interfering RNA (siRNA) in 2001 have paved the wave for gene targeting and...
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Development of RNA-Based Medicine for Colorectal Cancer: Current Scenario
Colorectal cancer (CRC) is one of the leading causes of death in both men and women worldwide. CRC is the third commonly diagnosed cancer and second...
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Octopamine receptor gene influences social grou** in the masked birch caterpillar
ObjectiveGroup-living plays a key role in the success of many insects, but the mechanisms underlying group formation and maintenance are poorly...
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Molecular identification of the chitinase genes in Aedes albopictus and essential roles of AaCht10 in pupal-adult transition
BackgroundAedes albopictus is an increasingly serious threat in public health due to it is vector of multiple arboviruses that cause devastating...
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Design and Evaluation of AgoshRNAs with 3′-Terminal HDV Ribozymes to Enhance the Silencing Activity
Since the first application of RNA interference (RNAi) in mammalian cells, the expression of short hairpin RNA (shRNA) molecules for targeted gene...
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Using Lentiviral shRNA Delivery to Knock Down Proteins in Cultured Neurons and In Vivo
Primary cultured neurons represent a benchmark preparation for studying neuronal cell biology. However, due to their poor transfection efficiency,...
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Synergistic action of the gut microbiota in environmental RNA interference in a leaf beetle
BackgroundRNA interference (RNAi) has emerged as an efficient tool to control insect pests. When insects ingest double-stranded RNAs (dsRNAs)...
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Design of AAV Vectors for Delivery of RNAi
Adeno-associated viral vectors have emerged as an important tool for human gene therapy, having demonstrated high transduction efficiency in a broad...
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RNA-seq analysis of chlorogenic acid intervention in duck embryo fibroblasts infected with duck plague virus
IntroductionChlorogenic acid, the primary active component in Chinese medicines like honeysuckle, exhibits anti-inflammatory and antiviral effects....
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A member of the CAP protein superfamily, Hc-CAP-15, is important for the parasitic-stage development of Haemonchus contortus
BackgroundThe CAP superfamily proteins are distributed widely in eukaryotes and play crucial roles in various biological processes. However, very...
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Molecular and functional characterization of a conserved odorant receptor from Aedes albopictus
BackgroundThe Asian tiger mosquito Aedes albopictus is a competent vector of several viral arboviruses including yellow fever, dengue fever, and...
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SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy
Elevated impulsivity is a key component of attention-deficit hyperactivity disorder (ADHD), bipolar disorder and juvenile myoclonic epilepsy (JME)....
