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2 Years into the Pandemic: What Did We Learn About the COVID-19 and Cerebellum?
Highly contagious pandemic due to novel coronavirus SARS-CoV-2, COVID-19 has significantly affected humankind. At the onset of the pandemic, it was...
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Cellular Localization and Distribution of TGF-β1, GDNF and PDGF-BB in the Adult Primate Central Nervous System
The available data on the localization of transforming growth factor beta1 (TGF-β1), glial cell line-derived neurotrophic factor (GDNF), and...
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Dorsolateral Prefrontal Cortex
The prefrontal cortex is known to play an important role in planning and controlling a variety of cognitive functions and in organizing and...
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Hyperammonemia Enhances GABAergic Neurotransmission in Hippocampus: Underlying Mechanisms and Modulation by Extracellular cGMP
Rats with chronic hyperammonemia reproduce the cognitive and motor impairment present in patients with hepatic encephalopathy. It has been proposed...
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Mass Spectrometry-Based Metabolomics Multi-platform for Alzheimer’s Disease Research
The integration of complementary analytical platforms is nowadays the most common strategy for comprehensive metabolomics analysis of complex...
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Relationship Between Reactive Astrocytes, by [18F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer’s Disease
Reactive astrocytes play an important role in the development of Alzheimer’s disease (AD). Here, we aimed to investigate the temporospatial...
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The Cerebellum in Niemann-Pick C1 Disease: Mouse Versus Man
Selective neuronal vulnerability is common to most degenerative disorders, including Niemann-Pick C (NPC), a rare genetic disease with altered...
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Different Activation of IL-10 in the Hippocampus and Prefrontal Cortex During Neurodegeneration Caused by Trimethyltin Chloride
Anti-inflammatory cytokine interleukin-10 (IL-10) plays a crucial role in controlling the resolution of inflammation. In this study, we aimed to...
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Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions
BackgroundDespite widespread acceptance that neuroinflammation contributes to age-related cognitive decline, studies comparing protein expression of...
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Map** the neuroanatomical abnormalities in a phenotype of male compulsive rats
Compulsivity is considered a transdiagnostic dimension in obsessive–compulsive and related disorders, characterized by heterogeneous cognitive and...
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Quantitative Proteomics Characterization of the Effect and Mechanism of Trichostatin A on the Hippocampus of Type II Diabetic Mice
Diabetic encephalopathy (DE) is one of the complications of diabetes mellitus with mild-to-moderate cognitive impairment. Trichostatin A (TSA) has...
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Cerebellar Transplantation: A Potential Model to Study Repair and Development of Neurons and Circuits in the Cerebellum
Neuronal transplantation offers a unique experimental situation for the in vivo study of cell-to-cell interactions between embryonic and adult neural...
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Research Note: Functional Connectivity Between a Corticostriatal Network and the Cerebellum
BackgroundBasal ganglia and cerebellum are structurally and functionally connected in animals. In humans, tractography and seed-based functional...
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Reactivity of the ventromedial prefrontal cortex, but not the amygdala, to negative emotion faces predicts greed personality trait
This study explored whether amygdala reactivity predicted the greed personality trait (GPT) using both task-based and resting-state functional...
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Altered connectivity in the cognitive control-related prefrontal cortex in Parkinson’s disease with rapid eye movement sleep behavior disorder
Rapid eye movement sleep behavior disorder (RBD) frequently occurs in Parkinson’s disease (PD), however, the exact pathophysiological mechanism is...
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The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure
Treatment of epilepsy remains a major problem as some epileptic patients do not respond to the current therapeutics. Transient receptor potential...
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The Effect of Hyperhomocysteinemia on the Content of Neurotrophins in Brain Structures of Pregnant Rats
Abstract —Maternal hyperhomocysteinemia (HHC) during pregnancy was shown to lead to disruption of fetal nervous system development and cause long-term...
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Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia
The anterior cingulate cortex (ACC) is a heterogeneous region of the brain’s limbic system that regulates cognitive and emotional processing, and is...
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Sex Differences in Rats with the Valproate Model of Autism: Disturbances in Social Behavior and Changes in Drd1 Gene Expression in Various Brain Structures
We report here studies using an experimental model of autism created by prenatal administration of valproic acid to produce a comparative analysis of...
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Early Postnatal Exposure to Intermittent Hypercapnic Hypoxia (IHH), but Not Nicotine, Decreases Reelin in the Young Piglet Hippocampus
This study evaluated the expression of reelin, an extracellular protein involved in lamination and migration of neurons, in the hippocampus of young...
