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Novel rat model of gaming disorder: assessment of social reward and sex differences in behavior and c-Fos brain activity
RationaleIn 2018, the International Classification of Diseases (ICD-11) classified Gaming Disorder (GD) as a mental disorder. GD mainly occurs among...
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Fast Scan Cyclic Voltammetry to Assess Dopamine Function: From Circuits to Behavior
Electrochemical techniques have allowed investigators to measure analytes of interest for decades. Of these techniques, fast scan cyclic voltammetry...
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Nutrition and Substance-Use Disorder
Substance-use disorder (SUD) has become a global cause of morbidity and mortality and has an impact on general mental health. Substance users are...
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Neurodevelopmental scaling is a major driver of brain–behavior differences in temperament across dog breeds
Behavioral traits like aggression, anxiety, and trainability differ significantly across dog breeds and are highly heritable. However, the neural...
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Disinhibition of the orbitofrontal cortex biases decision-making in obesity
The lateral orbitofrontal cortex (lOFC) receives sensory information about food and integrates these signals with expected outcomes to guide future...
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Sex differences in specific aspects of two animal tests of anxiety-like behavior
RationaleAnxiety, a negative state of high arousal and vigilance, is especially prevalent in women, making identification of underlying mechanisms...
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Chronic Stress Induced by Kee** in Conditions of Nesting Material Deficiency in the Early Postnatal Period Affects Behavior and Stress Reactivity in Male Rats
Rodent models of deprivation of parental care are increasingly used to model depression-like disorders induced by early stress. The present study...
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Hunger or thirst state uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making
Physiological need states direct decision-making toward re-establishing homeostasis. Using a two-alternative forced choice task for mice that models...
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Lack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats
Rationale and objectivePain-related factors increase the risk for opioid addiction, and pain may function as a negative reinforcer to increase opioid...
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Shortening time for access to alcohol drives up front-loading behavior, bringing consumption in male rats to the level of females
BackgroundIncentives to promote drinking (“happy hour”) can encourage faster rates of alcohol consumption, especially in women. Sex differences in...
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MK-801 Impairs Reconsolidation of a “New” Memory and Affects the “Old” Memory in Operant Feeding-Related Behavior in an Eight-Arm Radial Maze in Rats
Spatial memory deteriorated significantly in feeding-related operant behavior in an eight-arm radial maze in rats as a result of reactivation using a...
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Historical and Modern Perspectives on the Neuroscience of Habits
Habits are a crucial part of our daily lives. When they are aligned with our goals, they allow us to conserve cognitive resources so that we can...
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Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats
Glutamatergic neurons in ventral pallidum (VP Glu ) were recently reported to mediate motivational and emotional behavior, but its role in opioid...
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Dopamine modulation of sensory processing and adaptive behavior in flies
Behavioral flexibility for appropriate action selection is an advantage when animals are faced with decisions that will determine their survival or...
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CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state
This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in the context...
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Goal-Directed and Habitual Control in Human Drug Addiction
Learning theory has proposed that everyday actions are controlled by at least two dissociable systems: one that governs deliberate goal-directed...
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Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat
Food addiction (FA) is characterized by behavioral and neurochemical changes linked to loss of food intake control. Gut microbiota may influence...
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An economon model of drug addiction
The term “economon” (i:’ka.nə.muhn; plural: economa) is introduced here to describe an economic unit composed of two participants engaged in mutually...
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Individual differences in GHB consumption in a new voluntary GHB self-administration model in outbred rats
Background and purposeThe use of the recreational drug gamma-hydroxybutyric acid (GHB) has increased over the past decade, concomitantly leading to a...
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Dietary intake, eating behavior and physical activity in individuals with and without obstructive sleep apnea
Weight loss is one of the first line treatments for people with obstructive sleep apnea (OSA); however, people with OSA may have difficulties losing...