Abstract
Learning theory has proposed that everyday actions are controlled by at least two dissociable systems: one that governs deliberate goal-directed actions and another that regulates automatic habits; these two systems are thought to have inherently different functions. The goal-directed system guides actions toward achieving specific outcomes; this system can flexibly adapt to changing situations, but it is more effortful. By contrast, the habit system automates repeated actions by linking them to environmental cues; this system enhances one’s efficiency by making actions more automatic, but at the cost of reduced sensitivity to the consequences. A large body of neuroscientific evidence suggests that an optimal balance between these two systems is critical to support adaptive behavior, and a breakdown of this balance may induce maladaptive behaviors. An example of this breakdown can be seen in the context of drug addiction, a psychiatric disorder characterized by maladaptive drug use that spirals out of control. Patients with drug addiction not only prioritize drug use over other key aspects of their lives (e.g., work, school, interpersonal relationships), they also struggle to reduce their drug use; in severe cases, their drug use may even persist despite recurrent physical and psychological harm. Even if patients manage to abstain from drugs for prolonged periods, exposure to environments that have previously been associated with drugs often triggers relapse. These clinical symptoms of drug addiction have been hypothesized to reflect an imbalance between goal-directed and habitual control over behavior, with a bias toward the latter. In this chapter, we review recent experimental work in humans in support of this hypothesis.
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References
Adams, C. D., & Dickinson, A. (1981). Instrumental responding following reinforcer devaluation. The Quarterly Journal of Experimental Psychology Section B, 33(2b), 109–121. https://doi.org/10.1080/14640748108400816
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders: DSM-5. American Psychiatric Association.
Balleine, B. W., & Dickinson, A. (1998). Goal-directed instrumental action: Contingency and incentive learning and their cortical substrates. Neuropharmacology, 37(4), 407–419. https://doi.org/10.1016/S0028-3908(98)00033-1
Balleine, B. W., & O’Doherty, J. P. (2010). Human and rodent homologies in action control: Corticostriatal determinants of goal-directed and habitual action. Neuropsychopharmacology, 35(1), 48–69. https://doi.org/10.1038/npp.2009.131
Belin, D., & Everitt, B. J. (2008). Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron, 57(3), 432–441. https://doi.org/10.1016/j.neuron.2007.12.019
Belin, D., Jonkman, S., Dickinson, A., Robbins, T. W., & Everitt, B. J. (2009). Parallel and interactive learning processes within the basal ganglia: Relevance for the understanding of addiction. Behavioural Brain Research, 199(1), 89–102. https://doi.org/10.1016/j.bbr.2008.09.027
Belin, D., Belin-Rauscent, A., Murray, J. E., & Everitt, B. J. (2013). Addiction: Failure of control over maladaptive incentive habits. Current Opinion in Neurobiology, 23(4), 564–572. https://doi.org/10.1016/j.conb.2013.01.025
Breedon, J. R., Ziauddeen, H., Stochl, J., & Ersche, K. D. (2021). Feeding the addiction: Narrowing of goals to habits. European Neuropsychopharmacology, 42, 110–114. https://doi.org/10.1016/j.euroneuro.2020.11.002
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002). Emotion and motivation: The role of the amygdala, ventral striatum, and prefrontal cortex. Neuroscience and Biobehavioral Reviews, 26(3), 321–352. https://doi.org/10.1016/S0149-7634(02)00007-6
Chen, H., Nebe, S., Mojtahedzadeh, N., Kuitunen-Paul, S., Garbusow, M., Schad, D. J., Rapp, M. A., Huys, Q. J. M., Heinz, A., & Smolka, M. N. (2021). Susceptibility to interference between Pavlovian and instrumental control is associated with early hazardous alcohol use. Addiction Biology, 26(4), e12983. https://doi.org/10.1111/adb.12983
Colwill, R. M., & Rescorla, R. A. (1988). The role of response-reinforcer associations increases throughout extended instrumental training. Animal Learning & Behavior, 16(1), 105–111. https://doi.org/10.3758/BF03209051
Corbit, L. H., Nie, H., & Janak, P. H. (2012). Habitual alcohol seeking: Time course and the contribution of subregions of the dorsal striatum. Biological Psychiatry, 72(5), 389–395. https://doi.org/10.1016/j.biopsych.2012.02.024
Corbit, L. H., Chieng, B. C., & Balleine, B. W. (2014a). Effects of repeated cocaine exposure on habit learning and reversal by N-Acetylcysteine. Neuropsychopharmacology, 39(8), 1893–1901. https://doi.org/10.1038/npp.2014.37
Corbit, L. H., Nie, H., & Janak, P. H. (2014b). Habitual responding for alcohol depends upon both AMPA and D2 receptor signaling in the dorsolateral striatum. Frontiers in Behavioral Neuroscience, 8. https://doi.org/10.3389/fnbeh.2014.00301
Dalley, J. W., & Ersche, K. D. (2019). Neural circuitry and mechanisms of waiting impulsivity: Relevance to addiction. Philosophical Transactions of the Royal Society B: Biological Sciences, 374(1766), 20180145. https://doi.org/10.1098/rstb.2018.0145
Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2011). Impulsivity, compulsivity, and top-down cognitive control. Neuron, 69(4), 680–694. https://doi.org/10.1016/j.neuron.2011.01.020
de Wit, S., & Dickinson, A. (2009). Associative theories of goal-directed behaviour: A case for animal–human translational models. Psychological Research, 73(4), 463–476. https://doi.org/10.1007/s00426-009-0230-6
de Wit, S., Niry, D., Wariyar, R., Aitken, M. R. F., & Dickinson, A. (2007). Stimulus-outcome interactions during instrumental discrimination learning by rats and humans. Journal of Experimental Psychology: Animal Behavior Processes, 33(1), 1–11. https://doi.org/10.1037/0097-7403.33.1.1
de Wit, S., Kindt, M., Knot, S. L., Verhoeven, A. A. C., Robbins, T. W., Gasull-Camos, J., Evans, M., Mirza, H., & Gillan, C. M. (2018). Shifting the balance between goals and habits: Five failures in experimental habit induction. Journal of Experimental Psychology: General, 147(7), 1043. https://doi.org/10.1037/xge0000402
Deroche-Gamonet, V., Belin, D., & Piazza, P. V. (2004). Evidence for addiction-like behavior in the rat. Science, 305(5686), 1014–1017. https://doi.org/10.1126/science.1099020
Dias-Ferreira, E., Sousa, J. C., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J. J., Costa, R. M., & Sousa, N. (2009). Chronic stress causes frontostriatal reorganization and affects decision-making. Science, 325(5940), 621–625. https://doi.org/10.1126/science.1171203
Dickinson, A. (1985). Actions and habits: The development of behavioural autonomy. Philosophical Transactions of the Royal Society B, 308(1135), 67–78. https://doi.org/10.1098/rstb.1985.0010
Dickinson, A., Wood, N., & Smith, J. W. (2002). Alcohol seeking by rats: Action or habit? The Quarterly Journal of Experimental Psychology Section B, 55(4b), 331–348. https://doi.org/10.1080/0272499024400016
Ersche, K. D., Jones, P. S., Williams, G. B., Turton, A. J., Robbins, T. W., & Bullmore, E. T. (2012). Abnormal brain structure implicated in stimulant drug addiction. Science, 335, 601–604.
Ersche, K. D., Gillan, C. M., Jones, P. S., Williams, G. B., Ward, L. H. E., Luijten, M., de Wit, S., Sahakian, B. J., Bullmore, E. T., & Robbins, T. W. (2016). Carrots and sticks fail to change behavior in cocaine addiction. Science, 352(6292), 1468–1471. https://doi.org/10.1126/science.aaf3700
Ersche, K. D., Lim, T.-V., Ward, L. H. E., Robbins, T. W., & Stochl, J. (2017). Creature of habit: A self-report measure of habitual routines and automatic tendencies in everyday life. Personality and Individual Differences, 116, 73–85. https://doi.org/10.1016/j.paid.2017.04.024
Ersche, K. D., Ward, L. H. E., Lim, T.-V., Lumsden, R. J., Sawiak, S. J., Robbins, T. W., & Stochl, J. (2019). Impulsivity and compulsivity are differentially associated with automaticity and routine on the Creature of Habit Scale. Personality and Individual Differences, 150, 109493. https://doi.org/10.1016/j.paid.2019.07.003
Ersche, K. D., Meng, C., Ziauddeen, H., Stochl, J., Williams, G. B., Bullmore, E. T., & Robbins, T. W. (2020). Brain networks underlying vulnerability and resilience to drug addiction. Proceedings of the National Academy of Sciences, 117(26), 15253–15261. https://doi.org/10.1073/pnas.2002509117
Ersche, K. D., Lim, T. V., Murley, A. G., Rua, C., Vaghi, M. M., White, T. L., Williams, G. B., & Robbins, T. W. (2021). Reduced glutamate turnover in the putamen is linked with automatic habits in human cocaine addiction. Biological Psychiatry, 89(10), 970–979. https://doi.org/10.1016/j.biopsych.2020.12.009
Everitt, B. J., & Robbins, T. W. (2005). Neural systems of reinforcement for drug addiction: From actions to habits to compulsion. Nature Neuroscience, 8(11), 1481–1489. https://doi.org/10.1038/nn1579
Everitt, B. J., & Robbins, T. W. (2016). Drug addiction: Updating actions to habits to compulsions ten years on. Annual Review of Psychology, 67(1), 23–50. https://doi.org/10.1146/annurev-psych-122414-033457
Garbusow, M., Schad, D. J., Sommer, C., Jünger, E., Sebold, M., Friedel, E., Wendt, J., Kathmann, N., Schlagenhauf, F., Zimmermann, U. S., Heinz, A., Huys, Q. J. M., & Rapp, M. A. (2014). Pavlovian-to-instrumental transfer in alcohol dependence: A pilot study. Neuropsychobiology, 70(2), 111–121. https://doi.org/10.1159/000363507
Garbusow, M., Schad, D. J., Sebold, M., Friedel, E., Bernhardt, N., Koch, S. P., Steinacher, B., Kathmann, N., Geurts, D. E. M., Sommer, C., Müller, D. K., Nebe, S., Paul, S., Wittchen, H.-U., Zimmermann, U. S., Walter, H., Smolka, M. N., Sterzer, P., Rapp, M. A., et al. (2016). Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence. Addiction Biology, 21(3), 719–731. https://doi.org/10.1111/adb.12243
Garbusow, M., Nebe, S., Sommer, C., Kuitunen-Paul, S., Sebold, M., Schad, D. J., Friedel, E., Veer, I. M., Wittchen, H.-U., Rapp, M. A., Ripke, S., Walter, H., Huys, Q. J. M., Schlagenhauf, F., Smolka, M. N., & Heinz, A. (2019). Pavlovian-to-instrumental transfer and alcohol consumption in young male social drinkers: Behavioral, neural and polygenic correlates. Journal of Clinical Medicine, 8(8), Article 8. https://doi.org/10.3390/jcm8081188
Giuliano, C., Belin, D., & Everitt, B. J. (2019). Compulsive alcohol seeking results from a failure to disengage dorsolateral striatal control over behavior. The Journal of Neuroscience, 2615–2618. https://doi.org/10.1523/JNEUROSCI.2615-18.2018
Giuliano, C., Puaud, M., Cardinal, R. N., Belin, D., & Everitt, B. J. (2021). Individual differences in the engagement of habitual control over alcohol seeking predict the development of compulsive alcohol seeking and drinking. Addiction Biology, 26(6), e13041. https://doi.org/10.1111/adb.13041
Groman, S. M., Thompson, S. L., Lee, D., & Taylor, J. R. (2022). Reinforcement learning detuned in addiction: Integrative and translational approaches. Trends in Neurosciences, 45(2), 96–105. https://doi.org/10.1016/j.tins.2021.11.007
Hogarth, L., Attwood, A. S., Bate, H. A., & Munafò, M. R. (2012). Acute alcohol impairs human goal-directed action. Biological Psychology, 90(2), 154–160. https://doi.org/10.1016/j.biopsycho.2012.02.016
Hogarth, L., Balleine, B. W., Corbit, L. H., & Killcross, S. (2013). Associative learning mechanisms underpinning the transition from recreational drug use to addiction. Annals of the New York Academy of Sciences, 1282(1), 12–24. https://doi.org/10.1111/j.1749-6632.2012.06768.x
Hogarth, L., Lam-Cassettari, C., Pacitti, H., Currah, T., Mahlberg, J., Hartley, L., & Moustafa, A. (2019). Intact goal-directed control in treatment-seeking drug users indexed by outcome-devaluation and Pavlovian to instrumental transfer: Critique of habit theory. European Journal of Neuroscience, 50(3), 2513–2525. https://doi.org/10.1111/ejn.13961
Ito, R., Dalley, J. W., Robbins, T. W., & Everitt, B. J. (2002). Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated Cue. The Journal of Neuroscience, 22(14), 6247–6253. https://doi.org/10.1523/JNEUROSCI.22-14-06247.2002
Jentsch, J. D., & Taylor, J. R. (1999). Impulsivity resulting from frontostriatal dysfunction in drug abuse: Implications for the control of behavior by reward-related stimuli. Psychopharmacology, 146(4), 373–390. https://doi.org/10.1007/PL00005483
Jonkman, S., Pelloux, Y., & Everitt, B. J. (2012). Differential roles of the dorsolateral and midlateral striatum in punished cocaine seeking. Journal of Neuroscience, 32(13), 4645–4650. https://doi.org/10.1523/JNEUROSCI.0348-12.2012
LeBlanc, K. H., Maidment, N. T., & Ostlund, S. B. (2013). Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats. PLoS One, 8(4), e61355. https://doi.org/10.1371/journal.pone.0061355
Lim, T. V., & Ersche, K. D. (2023). Theory-driven computational models of drug addiction in humans: Fruitful or futile? Addiction Neuroscience, 5, 100066. https://doi.org/10.1016/j.addicn.2023.100066
Lim, T. V., Cardinal, R. N., Savulich, G., Jones, P. S., Moustafa, A. A., Robbins, T. W., & Ersche, K. D. (2019). Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder. Psychopharmacology, 236(8), 2359–2371. https://doi.org/10.1007/s00213-019-05330-z
Lim, T. V., Cardinal, R. N., Bullmore, E. T., Robbins, T. W., & Ersche, K. D. (2021). Impaired learning from negative feedback in stimulant use disorder: Dopaminergic modulation. International Journal of Neuropsychopharmacology, 24(11), 867–878. https://doi.org/10.1093/ijnp/pyab041
Lucantonio, F., Stalnaker, T. A., Shaham, Y., Niv, Y., & Schoenbaum, G. (2012). The impact of orbitofrontal dysfunction on cocaine addiction. Nature Neuroscience, 15(3), 358–366. https://doi.org/10.1038/nn.3014
Luijten, M., Gillan, C. M., de Wit, S., Franken, I. H. A., Robbins, T. W., & Ersche, K. D. (2020). Goal-directed and habitual control in smokers. Nicotine & Tobacco Research, 22(2), 188–195. https://doi.org/10.1093/ntr/ntz001
Lüscher, C., Robbins, T. W., & Everitt, B. J. (2020). The transition to compulsion in addiction. Nature Reviews Neuroscience, 21(5), Article 5. https://doi.org/10.1038/s41583-020-0289-z
Mangieri, R. A., Cofresí, R. U., & Gonzales, R. A. (2012). Ethanol seeking by long Evans rats is not always a goal-directed behavior. PLoS One, 7(8), e42886. https://doi.org/10.1371/journal.pone.0042886
Marshall, A. T., & Ostlund, S. B. (2018). Repeated cocaine exposure dysregulates cognitive control over cue-evoked reward-seeking behavior during Pavlovian-to-instrumental transfer. Learning & Memory, 25(9), 399–409. https://doi.org/10.1101/lm.047621.118
McKim, T. H., Bauer, D. J., & Boettiger, C. A. (2016). Addiction history associates with the propensity to form habits. Journal of Cognitive Neuroscience, 28(7), 1024–1038. https://doi.org/10.1162/jocn_a_00953
Miles, F. J., Everitt, B. J., & Dickinson, A. (2003). Oral cocaine seeking by rats: Action or habit? Behavioral Neuroscience, 117(5), 927–938. https://doi.org/10.1037/0735-7044.117.5.927
Murray, J. E., Belin, D., & Everitt, B. J. (2012). Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seeking. Neuropsychopharmacology, 37(11), Article 11. https://doi.org/10.1038/npp.2012.104
Nelson, A., & Killcross, S. (2006). Amphetamine exposure enhances habit formation. Journal of Neuroscience, 26(14), 3805–3812. https://doi.org/10.1523/JNEUROSCI.4305-05.2006
Nordquist, R. E., Voorn, P., de Mooij-van Malsen, J. G., Joosten, R. N. J. M. A., Pennartz, C. M. A., & Vanderschuren, L. J. M. J. (2007). Augmented reinforcer value and accelerated habit formation after repeated amphetamine treatment. European Neuropsychopharmacology, 17(8), 532–540. https://doi.org/10.1016/j.euroneuro.2006.12.005
Office for National Statistics (ONS). (2022, Dec 15). Drug misuse in England and Wales: Year ending June 2022. https://www.ons.gov.uk/peoplepopulationandcommunity/crimeandjustice/articles/drugmisuseinenglandandwales/yearendingjune2022
Pelloux, Y., Everitt, B. J., & Dickinson, A. (2007). Compulsive drug seeking by rats under punishment: Effects of drug taking history. Psychopharmacology, 194(1), 127–137. https://doi.org/10.1007/s00213-007-0805-0
Pool, E. R., Gera, R., Fransen, A., Perez, O. D., Cremer, A., Aleksic, M., Tanwisuth, S., Quail, S., Ceceli, A. O., Manfredi, D. A., Nave, G., Tricomi, E., Balleine, B., Schonberg, T., Schwabe, L., & O’Doherty, J. P. (2022). Determining the effects of training duration on the behavioral expression of habitual control in humans: A multilaboratory investigation. Learning & Memory, 29(1), 16–28. https://doi.org/10.1101/lm.053413.121
Porrino, L. J., Lyons, D., Miller, M. D., Smith, H. R., Friedman, D. P., Daunais, J. B., & Nader, M. A. (2002). Metabolic map** of the effects of cocaine during the initial phases of self-administration in the nonhuman primate. The Journal of Neuroscience, 22(17), 7687–7694. https://doi.org/10.1523/JNEUROSCI.22-17-07687.2002
Porrino, L. J., Lyons, D., Smith, H. R., Daunais, J. B., & Nader, M. A. (2004). Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains. Journal of Neuroscience, 24(14), 3554–3562. https://doi.org/10.1523/JNEUROSCI.5578-03.2004
Ramakrishnan, S., Robbins, T. W., & Zmigrod, L. (2021). The Habitual Tendencies Questionnaire: A tool for psychometric individual differences research. Personality and Mental Health, pmh.1524. https://doi.org/10.1002/pmh.1524
Renteria, R., Baltz, E. T., & Gremel, C. M. (2018). Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits. Nature Communications, 9(1). https://doi.org/10.1038/s41467-017-02615-9
Robbins, T. W., Gillan, C. M., Smith, D. G., de Wit, S., & Ersche, K. D. (2012). Neurocognitive endophenotypes of impulsivity and compulsivity: Towards dimensional psychiatry. Trends in Cognitive Sciences, 16(1), 81–91. https://doi.org/10.1016/j.tics.2011.11.009
Saddoris, M. P., Stamatakis, A., & Carelli, R. M. (2011). Neural correlates of Pavlovian-to-instrumental transfer in the nucleus accumbens shell are selectively potentiated following cocaine self-administration. European Journal of Neuroscience, 33(12), 2274–2287. https://doi.org/10.1111/j.1460-9568.2011.07683.x
Schoenbaum, G., & Setlow, B. (2005). Cocaine makes actions insensitive to outcomes but not extinction: Implications for altered orbitofrontal–Amygdalar function. Cerebral Cortex, 15(8), 1162–1169. https://doi.org/10.1093/cercor/bhh216
Schoenbaum, G., Roesch, M. R., & Stalnaker, T. A. (2006). Orbitofrontal cortex, decision-making and drug addiction. Trends in Neurosciences, 29(2), 116–124. https://doi.org/10.1016/j.tins.2005.12.006
Schwabe, L., & Wolf, O. T. (2009). Stress prompts habit behavior in humans. Journal of Neuroscience, 29(22), 7191–7198. https://doi.org/10.1523/JNEUROSCI.0979-09.2009
Schwabe, L., Dickinson, A., & Wolf, O. T. (2011). Stress, habits, and drug addiction: A psychoneuroendocrinological perspective. Experimental and Clinical Psychopharmacology, 19(1), 53–63. https://doi.org/10.1037/a0022212
Sekutowicz, M., Guggenmos, M., Kuitunen-Paul, S., Garbusow, M., Sebold, M., Pelz, P., Priller, J., Wittchen, H.-U., Smolka, M. N., Zimmermann, U. S., Heinz, A., Sterzer, P., & Schmack, K. (2019). Neural response patterns during Pavlovian-to-instrumental transfer predict alcohol relapse and young adult drinking. Biological Psychiatry, 86(11), 857–863. https://doi.org/10.1016/j.biopsych.2019.06.028
Shields, C. N., & Gremel, C. M. (2021). Prior chronic alcohol exposure enhances Pavlovian-to-instrumental transfer. Alcohol, 96, 83–92. https://doi.org/10.1016/j.alcohol.2021.07.004
Shields, C. N., & Gremel, C. M. (2022). Effects of central amygdala chemogenetic manipulation and prior chronic alcohol exposure on Pavlovian-to-instrumental transfer. Alcoholism: Clinical and Experimental Research, 46(11), 1967–1979. https://doi.org/10.1111/acer.14948
Sjoerds, Z., de Wit, S., van den Brink, W., Robbins, T. W., Beekman, A. T. F., Penninx, B. W. J. H., & Veltman, D. J. (2013). Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients. Translational Psychiatry, 3(12), e337. https://doi.org/10.1038/tp.2013.107
Sommer, C., Garbusow, M., Jünger, E., Pooseh, S., Bernhardt, N., Birkenstock, J., Schad, D. J., Jabs, B., Glöckler, T., Huys, Q. M., Heinz, A., Smolka, M. N., & Zimmermann, U. S. (2017). Strong seduction: Impulsivity and the impact of contextual cues on instrumental behavior in alcohol dependence. Translational Psychiatry, 7(8), e1183–e1183. https://doi.org/10.1038/tp.2017.158
Sommer, C., Birkenstock, J., Garbusow, M., Obst, E., Schad, D. J., Bernhardt, N., Huys, Q. M., Wurst, F. M., Weinmann, W., Heinz, A., Smolka, M. N., & Zimmermann, U. S. (2020). Dysfunctional approach behavior triggered by alcohol-unrelated Pavlovian cues predicts long-term relapse in alcohol dependence. Addiction Biology, 25(1), e12703. https://doi.org/10.1111/adb.12703
Takahashi, T. T., Vengeliene, V., Enkel, T., Reithofer, S., & Spanagel, R. (2019). Pavlovian to instrumental transfer responses do not correlate with addiction-like behavior in rats. Frontiers in Behavioral Neuroscience, 13. https://www.frontiersin.org/articles/10.3389/fnbeh.2019.00129
Tanaka, S. C., Balleine, B. W., & O’Doherty, J. P. (2008). Calculating consequences: Brain systems that encode the causal effects of actions. Journal of Neuroscience, 28(26), 6750–6755. https://doi.org/10.1523/JNEUROSCI.1808-08.2008
Taylor, J. R., & Robbins, T. W. (1984). Enhanced behavioural control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens. Psychopharmacology, 84(3), 405–412. https://doi.org/10.1007/BF00555222
Taylor, J. R., & Robbins, T. W. (1986). 6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine. Psychopharmacology, 90(3), 390–397. https://doi.org/10.1007/BF00179197
Tricomi, E., Balleine, B. W., & O’Doherty, J. P. (2009). A specific role for posterior dorsolateral striatum in human habit learning. European Journal of Neuroscience, 29(11), 2225–2232. https://doi.org/10.1111/j.1460-9568.2009.06796.x
UNODC. (2022). World drug report 2022. United Nations Publication. https://www.unodc.org/res/wdr2022/MS/WDR22_Booklet_1.pdf
Valentin, V. V., Dickinson, A., & O’Doherty, J. P. (2007). Determining the neural substrates of goal-directed learning in the human brain. Journal of Neuroscience, 27(15), 4019–4026. https://doi.org/10.1523/JNEUROSCI.0564-07.2007
van Timmeren, T., Quail, S. L., Balleine, B. W., Geurts, D. E. M., Goudriaan, A. E., & van Holst, R. J. (2020). Intact corticostriatal control of goal-directed action in alcohol use disorder: A Pavlovian-to-instrumental transfer and outcome-devaluation study. Scientific Reports, 10(1), Article 1. https://doi.org/10.1038/s41598-020-61892-5
Vanderschuren, L. J. M. J., & Everitt, B. J. (2004). Drug seeking becomes compulsive after prolonged cocaine self-administration. Science, 305(5686), 1017–1019. https://doi.org/10.1126/science.1098975
Watson, P., & de Wit, S. (2018). Current limits of experimental research into habits and future directions. Current Opinion in Behavioral Sciences, 20, 33–39. https://doi.org/10.1016/j.cobeha.2017.09.012
Wood, W., & Neal, D. T. (2007). A new look at habits and the habit-goal interface. Psychological Review, 114(4), 843–863. https://doi.org/10.1037/0033-295X.114.4.843
Wood, W., & Rünger, D. (2016). Psychology of habit. Annual Review of Psychology, 67(1), 289–314. https://doi.org/10.1146/annurev-psych-122414-033417
Wyvell, C. L., & Berridge, K. C. (2000). Intra-Accumbens amphetamine increases the conditioned incentive salience of sucrose reward: Enhancement of reward “Wanting” without enhanced “Liking” or response reinforcement. The Journal of Neuroscience, 20(21), 8122–8130. https://doi.org/10.1523/JNEUROSCI.20-21-08122.2000
Wyvell, C. L., & Berridge, K. C. (2001). Incentive sensitization by previous amphetamine exposure: Increased Cue-triggered “Wanting” for sucrose reward. The Journal of Neuroscience, 21(19), 7831–7840. https://doi.org/10.1523/JNEUROSCI.21-19-07831.2001
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2005a). Blockade of NMDA receptors in the dorsomedial striatum prevents action–outcome learning in instrumental conditioning. European Journal of Neuroscience, 22(2), 505–512. https://doi.org/10.1111/j.1460-9568.2005.04219.x
Yin, H. H., Ostlund, S. B., Knowlton, B. J., & Balleine, B. W. (2005b). The role of the dorsomedial striatum in instrumental conditioning. European Journal of Neuroscience, 22(2), 513–523. https://doi.org/10.1111/j.1460-9568.2005.04218.x
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2006). Inactivation of dorsolateral striatum enhances sensitivity to changes in the action–outcome contingency in instrumental conditioning. Behavioural Brain Research, 166(2), 189–196. https://doi.org/10.1016/j.bbr.2005.07.012
Zapata, A., Minney, V. L., & Shippenberg, T. S. (2010). Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats. Journal of Neuroscience, 30(46), 15457–15463. https://doi.org/10.1523/JNEUROSCI.4072-10.2010
Acknowledgment and Financial Disclosures
We are grateful to Dorothy Langton and her family for their generous support toward our work. TVL received an Angharad Dodds John bursary in Mental Health and Neuropsychiatry. KDE receives editorial honoraria from Karger Publishers.
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Lim, T.V., Ersche, K.D. (2024). Goal-Directed and Habitual Control in Human Drug Addiction. In: Vandaele, Y. (eds) Habits. Springer, Cham. https://doi.org/10.1007/978-3-031-55889-4_11
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