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Seizure Rescue Therapies: Comparing Approved and Commonly Used Benzodiazepine Formulations
Acute seizure therapies given out of the hospital are important for interrupting acute repetitive and prolonged seizures and preventing...
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Neurobehavioral protective effects of Japanese sake yeast supplement against chronic stress-induced anxiety and depression-like symptoms in mice: Possible role of central adenosine receptors
RationaleUsing routine synthetic drugs in the treatment of psychiatric disorders may have some restrictions due to serious side effects and...
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Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies
Epilepsy, a chronic neurological condition, impacts millions of individuals globally and remains a significant contributor to both illness and...
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Sub-acute toxicity study of the aqueous extract from leaves and flowers of Acmella caulirhiza on female albino Wistar rats
ObjectAcmella caulirhiza is a medicinal plant traditionally widely used in Cameroon for the management of several pathologies, hence the need for...
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Foreign Compounds: Foods, Drugs, Chemicals, and Lifestyles
Foods are substances that contain essential nutrients such as proteins, carbohydrates...
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Evaluation of pharmacological potentials of the aerial part of Achyranthes aspera L.: in vivo, in vitro and in silico approaches
Achyranthes aspera L. (Prickly Chaff flower) is an imperative Asian herb that has been known for numerous healing powers. The aim of this research is...
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The role of nitric oxide in anticonvulsant effects of lycopene supplementation on pentylenetetrazole-induced epileptic seizures in rats
Recent studies have shown that natural antioxidant compounds have positive effects on the nervous system. Lycopene, the red pigment in tomatoes, is...
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Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures
This research aimed to assess the effect of perillyl alcohol (PA) on convulsive behavior in vivo using adult zebrafish ( Danio rerio , both sexes). The...
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Therapeutic potential of Bergenin in the management of neurological-based diseases and disorders
Originally sourced from plants, Bergenin has been used as a medicinal compound in traditional medicine for centuries, and anecdotal reports suggest a...
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Intranasal Allopregnanolone Confers Rapid Seizure Protection: Evidence for Direct Nose-to-Brain Delivery
Allopregnanolone, a positive modulator of GABA A receptors with antiseizure activity, has potential in the treatment of seizure emergencies....
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Failure to reduce benzodiazepine prescriptions through the implementation of a psychological intervention for insomnia in an Italian mental health service
PurposeDespite the evidence of higher effectiveness of psychological interventions for insomnia compared to pharmacological ones, drug prescriptions...
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5-HT Neural System Abnormalities in PTSD Model Rats
To do translational research on illness, a suitable animal model is needed. Since the symptoms of post-traumatic stress disorder (PTSD) exist across...
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Pharmacological modulation of conditioned fear in the fear-potentiated startle test: a systematic review and meta-analysis of animal studies
Rationale and objectivesFear conditioning is an important aspect in the pathophysiology of anxiety disorders. The fear-potentiated startle test is...
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Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat
Hyssopus officinalis L. is one of the most important medicinal plants in traditional medicine used to treat seizures. In this study, we assessed the...
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The Management of Neurological Symptoms in Palliative Care
Neurological disease is a major cause of disability and death across the world. There is increasing evidence that palliative care is effective in...
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N-Formyl-Methionyl-Leucyl-Phenylalanine Plays a Neuroprotective and Anticonvulsant Role in Status Epilepticus Model
Status epilepticus (SE) is described as continuous and self-sustaining seizures, which triggers hippocampal neurodegeneration, inflammation, and...
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HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats
Anxiety is a common mental disorder, and its prevalence has lately increased because of the COVID-19 pandemic. Unfortunately, the available...
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Structure-function Studies of GABA (A) Receptors and Related computer-aided Studies
The γ-aminobutyric acid type A receptor (GABA (A) receptor) is a membrane protein activated by the neurotransmitter GABA. Structurally, this major...
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Exploring gender differences in pharmacokinetics of central nervous system related medicines based on a systematic review approach
Due to the inevitable differences in physiological and/or genetic factors between genders, the possibility that differences in pharmacokinetics...
