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Vpr driving DNA methylation variation of CD4 + T cells in HIV-1 infection
BackgroundDespite the existence of available therapeutic interventions for HIV-1, this virus remains a significant global threat, leading to...
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Steady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis
Memory-phenotype (MP) CD4 + T cells are a substantial population of conventional T cells that exist in steady-state mice, yet their immunological...
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Coculture of Human Dendritic and T Cells for the Study of Specific T Cell-Mediated Responses Against Food Allergens
Dendritic cells (DCs) connect innate and adaptive immunity by sampling, capturing, processing, and presenting the allergen to distinct subsets of...
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Nano-optogenetic CAR-T Cell Immunotherapy
Chimeric antigen receptor (CAR)-T cell immunotherapy emerges as an effective cancer treatment. However, significant safety concerns remain, such as...
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Functional Analysis of Foxp3 and Its Mutants by Retroviral Transduction of Murine Primary CD4+ T Cells
The transcription factor Foxp3/FOXP3 orchestrates regulatory T (Treg) cell development and function by interacting with numerous target genes and...
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How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion
Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-stimulatory molecules to either undergo clonal deletion or to...
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Identification of human exTreg cells as CD16+CD56+ cytotoxic CD4+ T cells
In atherosclerosis, some regulatory T (T reg ) cells become exT reg cells. We crossed inducible T reg and exT reg cell lineage-tracker mice ( FoxP3 eGFP−Cre-ERT2...
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Multiparameter Flow Cytometry Monitoring of T Cell Responses
Multiparameter flow cytometry is a common tool for assessing responses of T, B, and other cells to pathogens or vaccines. Such responses are likely...
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Immune checkpoints are predominantly co-expressed by clonally expanded CD4+FoxP3+ intratumoral T-cells in primary human cancers
BackgroundIn addition to anti-PD(L)1, anti-CTLA-4 and anti-LAG-3, novel immune checkpoint proteins (ICP)-targeted antibodies have recently failed to...
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Intestinal helminth infection transforms the CD4+ T cell composition of the skin
Intestinal helminth parasites can alter immune responses to vaccines, other infections, allergens and autoantigens, implying effects on host immune...
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The gene expression profile and cell of origin of canine peripheral T-cell lymphoma
BackgroundPeripheral T-cell lymphoma (PTCL) refers to a heterogenous group of T-cell neoplasms with poor treatment responses and survival times....
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Dual T-cell constant β chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry
The diagnosis of leukemic T-cell malignancies is often challenging, due to overlap** features with reactive T-cells and limitations of currently...
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How to Test Human CAR T Cells in Solid Tumors, the Next Frontier of CAR T Cell Therapy
Chimeric antigen receptor (CAR) T cell therapy has proven to be a successful treatment option for leukemias and lymphomas. These encouraging outcomes...
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Genetic Modification of Tumor-Infiltrating Lymphocytes, Peripheral T Cells, and T-Cell Model Cell Lines
Genetic modification of tumor-infiltrating lymphocytes (TILs) or circulating T cells has become an important avenue in cancer therapy. Here we...
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Phenotypic and Functional Characterization of Memory CD4+ and CD8+ T Cells After Antigenic Stimulation
The encounter of T cells with the antigen through the interaction of T cell receptors with peptides and major histocompatibility complex (MHC)...
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Self-adjuvanting nanovaccines boost lung-resident CD4+ T cell immune responses in BCG-primed mice
Heterologous vaccine regimens could extend waning protection in the global population immunized with Mycobacterium bovis Bacille Calmette-Guerin...
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Associations of different immune checkpoints-expressing CD4+ Treg/ T cell subsets with disease-free survival in colorectal cancer patients
There are different subsets of T regulatory cells (Tregs), orchestrating critical roles in the regulation of anti-tumor immunity in colorectal cancer...
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Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells
Despite antiretroviral therapy (ART), HIV persistence in the central nervous system (CNS) continues to cause a range of cognitive impairments in...
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Control of CD4+ T Cell Differentiation and Function by PI3K Isoforms
The phosphoinositide-3-kinase (PI3K) pathway is a highly conserved intracellular signaling pathway involving numerous key effectors which, in...
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Potential clinical implications of CD4+CD26high T cells for nivolumab treated melanoma patients
BackgroundNivolumab is an anti-PD1 antibody that has dramatically improved metastatic melanoma patients’ outcomes. Nevertheless, many patients are...
