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Plasmodium falciparum: Transporter and Drug Target
Malaria will continue to be a concern for public health well into the future, as it is responsible for more than 50 million fatalities annually...
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Pharmacogenomics of Anti-Infective Agents
Ever since we know that the dissimilarities of medications are influenced by the in vivo process of the body, including absorption, distribution,...
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Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer
BackgroundCancer-associated fibroblasts (CAFs) are activated fibroblasts associated with cancer. They have an important role in tumor growth and...
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Limitations of Current Drugs and Prospects of Plant-Based Compounds and Their Constructed Analogs as Therapeutics for Treatment of Malaria
Antimalarial drug resistance is persistently posing a major risk for eradicating malaria and is the key challenge for radically curing malaria....
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Short-Chain Fatty Acids as Therapeutic Agents in Colon Malignancies
Colon cancer has taken a large number of lives worldwide and stands among the few topmost killer malignancies. Although several approaches to combat...
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Artemisinin suppresses hepatocellular carcinoma cell growth, migration and invasion by targeting cellular bioenergetics and Hippo-YAP signaling
The primary liver cancer (PLC) is one of the leading causes of cancer-related death worldwide. The predominant form of PLC is hepatocellular...
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Evaluation of anti-malarial potency of new pyrazole-hydrazine coupled to Schiff base derivatives
BackgroundThe search for pharmacologically effective agents among molecules bearing multiple functionalities is commonly practiced. In continuation...
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Natural Dietary Alkaloids and Its Synthetic Derivatives as Oxidative Stress-Inducing Agents for Cancer Therapy
Excessive production of reactive oxygen species in the system is the cause of various diseases. This in turn causes stress in the body, which must be...
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Inhibitory Effect of Two Carbonic Anhydrases Inhibitors on the Activity of Major Cytochrome P450 Enzymes
Background and ObjectivesBoth AW-9A (coumarin derivative) and WES-1 (sulfonamide derivative) were designed and synthesized as potential selective...
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Combating antimicrobial resistance in malaria, HIV and tuberculosis
Antimicrobial resistance poses a significant threat to the sustainability of effective treatments against the three most prevalent infectious...
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Current Treatments for Malaria
Antimalarial drug therapy is the recommended measure for malaria patients. In the chapter, the treatment for uncomplicated malaria, severe and...
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Introduction: An Overview of Malaria and Plasmodium
Malaria is a terrible infectious disease that affects people all over the world. Because it is so common in economically develo** regions’ poorer...
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Nontoxic Natural Products as Regulators of Tumor Suppressor Gene Function
Cancer is a multifactorial disorder caused by the accumulation of multiple genetic, epigenetic lesions or its combination on cancer critical genes,...
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Immunomodulatory Role of Terpenoids and Phytosteroids
The immune system in vertebrates comprises a complex and sophisticated defense system and is traditionally divided in two types: innate immunity and...
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Curcuminoids with Antineurodegenerative Properties: Current Trends and Future Perspectives
Curcuminoids are bioactive compounds found in Curcuma longa Linn. (Zingiberaceae), a species commonly known as turmeric or turmeric root, widely used...
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9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation
Human inflammatory disease, multiple sclerosis (MS), is a demyelinating disease of central nervous system (CNS). The experimental autoimmune...
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Diverse Pharmacological Activities of 4-Aminoquinoline and its Derivatives
Compounds containing 4-aminoquinoline moiety are known to exhibit various pharmacological properties such as antimalarial, anticancer, antitubercular...
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Therapeutic efficacy of pyronaridine-artesunate (Pyramax®) against uncomplicated Plasmodium falciparum infection at Hamusit Health Centre, Northwest Ethiopia
BackgroundEarly case detection and prompt treatment are important malaria control and elimination strategies. However, the emergence and rapid spread...
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Endoplasmic Reticulum Stress and Emerging Therapeutic Targets in Cancer
Endoplasmic reticulum stress (ER stress) is characterized by the accumulation of misfolded and unfolded proteins in the ER lumen. To mitigate the...
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Repurposing of anti-malarial drugs for the treatment of tuberculosis: realistic strategy or fanciful dead end?
BackgroundDrug repurposing offers a strategic alternative to the development of novel compounds, leveraging the known safety and pharmacokinetic...