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Aryl hydrocarbon receptor activation drives polymorphonuclear myeloid-derived suppressor cell response and efficiently attenuates experimental Sjögren’s syndrome
Myeloid-derived suppressor cells (MDSCs) comprise heterogeneous myeloid cell populations with immunosuppressive capacity that contribute to immune...
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The aryl hydrocarbon receptor in liver inflammation
The aryl hydrocarbon receptor (AHR) is a ubiquitously expressed ligand-activated transcription factor with multifaceted physiological functions. In...
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Thifluzamide exposure induced neuro-endocrine disrupting effects in zebrafish (Danio rerio)
Thifluzamide is widely used fungicide and frequently detected in aquatic system. In this study, the toxicity of fungicide thifluzamide to...
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Animal Model of Human Cancer: Malignant Lymphoma/Colon Cancer/Lung Cancer/Liver Cancer/Brain Tumors/Skin Cancer
Considering that the number of people who died from cancer alone in 2020 is more than ten million, the importance of early diagnosis and treatment is...
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The absence of AhR in CD4+ T cells in patients with acute graft-versus-host disease may be related to insufficient CTCF expression
BackgroundAcute graft-versus-host disease (aGVHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation...
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Evolution of Zebrafish as a Novel Pharmacological Model in Endocrine Research
Zebrafish is a powerful platform in the modern era of phenotype-based drug discovery and eminent vertebrate model to study disease progression and...
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Nuclear receptors: a bridge linking the gut microbiome and the host
BackgroundThe gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut...
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Toxicodynamic Tests
Toxicodynamic testing is aimed at the elucidation of adverse effects of chemicals including understanding of their mode of action. In many cases, the...
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Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New Opportunities
Population studies show worrisome trends towards earlier breast development, difficulty in breastfeeding, and increasing rates of breast cancer in...
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Toxicodynamic Tests
Toxicodynamic testing is aimed at the elucidation of adverse effects of chemicals including understanding of their mode of action. In many cases, the...
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Effects of Environmental Endocrine-Disrupting Chemicals on Female Reproductive Health
Environmental endocrine-disrupting chemicals (EDCs) are xenobiotic compounds that are frequently contacted in daily life. With the species and...
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Gastrodin: a comprehensive pharmacological review
Tianma is the dried tuber of Gastrodia elata Blume ( G. elata ), which is frequently utilized in clinical practice as a traditional Chinese medicine....
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Food Contaminants
Nowadays, with food safety incidents occurring repeatedly in many countries, consumers and organizations are increasingly concerned about the quality...
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Comparative toxicoproteogenomics of mouse and rat liver identifies TCDD-resistance genes
The aryl hydrocarbon receptor (AHR) mediates many toxic effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD). However, the AHR alone does not...
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Bibliometric analysis of Naunyn–Schmiedeberg’s Archives of Pharmacology (1947–1974)
Naunyn–Schmiedeberg’s Archives of Pharmacology is the oldest pharmacological journal, founded in 1873. This bibliometric analysis examines the...
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Environmental toxicant-mediated cardiovascular diseases: an insight into the mechanism and possible preventive strategy
BackgroundCardiovascular system is saddled with responsibility of pum** blood into circulation, thereby providing nourishment to tissues and...
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Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota
AbstractGut microbiota in interaction with intestinal host tissues influences many brain functions and microbial dysbiosis has been linked with brain...
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Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1
Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in individuals with cancer; however, such factors have not yet been...
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Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease
Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe inflammation in Kupffer cells (KCs) despite the increased...
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Histone Modifying Potential of Dietary Phytochemicals: Implications in Treating Breast Cancer
Purpose of ReviewBreast cancer is a metastatic carcinoma that is recognized as a leading cause of death in women worldwide and is still an unanswered...
