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Role of microRNA-363 during tumor progression and invasion
Recent progresses in diagnostic and therapeutic methods have significantly improved prognosis in cancer patients. However, cancer is still considered...
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Contribution of extracellular vesicles for the pathogenesis of retinal diseases: shedding light on blood-retinal barrier dysfunction
Retinal degenerative diseases, including diabetic retinopathy (DR) and age-related macular degeneration (AMD), loom as threats to vision, causing...
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Role of non-coding RNAs in neuroblastoma
Neuroblastoma is known as the most prevalent extracranial malignancy in childhood with a neural crest origin. It has been widely accepted that...
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circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p
BackgroundEsophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor worldwide. Circular RNA (circRNA) is of great value in...
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Extracellular vesicle-based liquid biopsy biomarkers and their application in precision immuno-oncology
While the field of precision oncology is rapidly expanding and more targeted options are revolutionizing cancer treatment paradigms, therapeutic...
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Spinal Cord Injury: From MicroRNAs to Exosomal MicroRNAs
Spinal cord injury (SCI) is an unfortunate experience that may generate extensive sensory and motor disabilities due to the destruction and passing...
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MicroRNA expression signature as a biomarker in the diagnosis of nodal T-cell lymphomas
BackgroundThe diagnosis of T-cell lymphomas is typically established through a multiparameter approach that combines clinical, morphologic,...
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Recent advances of exosomal circRNAs in cancer and their potential clinical applications
Circular RNA (circRNA) is a type of non-coding RNA that forms a covalently closed, uninterrupted loop. The expression of circRNA differs among cell...
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Long noncoding RNAs: glycolysis regulators in gynaecologic cancers
The three most common gynaecologic cancers that seriously threaten female lives and health are ovarian cancer, cervical cancer, and endometrial...
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Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression
Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are covalently closed loop structures formed by precursor mRNAs...
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Analyzing the role of ACE2, AR, MX1 and TMPRSS2 genetic markers for COVID-19 severity
BackgroundThe use of molecular biomarkers for COVID-19 remains unconclusive. The application of a molecular biomarker in combination with clinical...
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An overview of CCN4 (WISP1) role in human diseases
CCN4 (cellular communication network factor 4), a highly conserved, secreted cysteine-rich matricellular protein is emerging as a key player in the...
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Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views
The transcription factor family activator protein 2 (TFAP2) is vital for regulating both embryonic and oncogenic development. The TFAP2 family...
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miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer’s disease
BackgroundAlzheimer’s dementia (AD) pathogenesis involves complex mechanisms, including microRNA (miRNA) dysregulation. Integrative network and...
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Differences in Transcriptomic Profiles of Brain and Thyroid Tumors with NTRK Gene Rearrangement
For tumors with chimeric NTRK genes, entrectinib and larotrectinib can be prescribed regardless of tumor localization. We compared changes in the...
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Therapeutic Approaches and Models in Retinoblastoma
In cancer research, animal models constitute an essential aspect of preclinical investigations. In various human malignancies, such as ovarian,...
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Alzheimer’s Disease-Related Epigenetic Changes: Novel Therapeutic Targets
Aging is a significant risk factor for Alzheimer’s disease (AD), although the precise mechanism and molecular basis of AD are not yet fully...
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Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance
There has been a surge of interest in recent years in understanding the intricate mechanisms underlying cancer progression and treatment resistance....
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The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies
After skin malignancy, breast cancer is the most widely recognized cancer detected in women in the United States. Breast cancer (BCa) can happen in...
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The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely related in the process of...
