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Gut microbiota, circulating inflammatory markers and metabolites, and carotid artery atherosclerosis in HIV infection
BackgroundAlterations in gut microbiota have been implicated in HIV infection and cardiovascular disease. However, how gut microbial alterations...
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Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome
Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer’s disease and its diverse pathological processes are urgently...
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The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases
One of the main burdens in the treatment of diseases is imputable to the delay between the appearance of molecular dysfunctions in the first affected...
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Progress in mass spectrometry approaches to profiling protein–protein interactions in the studies of the innate immune system
Understanding protein–protein interactions (PPIs) is pivotal for deciphering the intricacies of biological processes. Dysregulation of PPIs underlies...
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Serum protein profiling reveals an inflammation signature as a predictor of early breast cancer survival
BackgroundBreast cancers exhibit considerable heterogeneity in their biology, immunology, and prognosis. Currently, no validated, serum protein-based...
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The localization of molecularly distinct microglia populations to Alzheimer's disease pathologies using QUIVER
New histological techniques are needed to examine protein distribution in human tissues, which can reveal cell shape and disease pathology...
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Cerebrospinal Fluid as a Platform for Biomarker Identification in Traumatic Brain Injury
Traumatic brain injury (TBI) is a common cause for mortality and disability following severe head injury as well as milder concussive head injury....
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Antinociceptive Activity of Vanilloids in Caenorhabditis elegans is Mediated by the Desensitization of the TRPV Channel OCR-2 and Specific Signal Transduction Pathways
Vanilloids, including capsaicin and eugenol, are ligands of transient receptor potential channel vanilloid subfamily member 1 (TRPV1). Prolonged...
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Screening inflammatory protein biomarkers on premature infants with necrotizing enterocolitis
ObjectiveThis study aimed to explore potential inflammatory biomarkers for early prediction of necrotizing enterocolitis (NEC) in premature infants.
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Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic...
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The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry
Prader–Willi syndrome (PWS) is a neurodevelopmental disorder caused by the loss of function of a set of imprinted genes on chromosome 15q11–15q13....
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Structural proteomics, electron cryo-microscopy and structural modeling approaches in bacteria–human protein interactions
A central challenge in infection medicine is to determine the structure and function of host–pathogen protein–protein interactions to understand how...
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Liquid biopsy: creating opportunities in brain space
In recent years, liquid biopsy has emerged as an alternative method to diagnose and monitor tumors. Compared to classical tissue biopsy procedures,...
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The Role of Post-Translational Modifications in Cancer
Enzymatic post-translational modifications (PTMs) regulate the structure, function, and stability of proteins that are involved in a myriad of vital...
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Longevity-associated BPIFB4 gene counteracts the inflammatory signaling
BackgroundIncreased levels of pro-inflammatory proteins in plasma can be detected in older individuals and associate with the so called chronic...
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The rise of targeting chimeras (TACs): next-generation medicines that preempt cellular events
Traditional targets and modalities that have provided rich substrates for medicine design and decades of productive industrial and academic research...
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Biomarkers in Precision Medicine with Special Reference to Oncology
A major global health problem that is growing worse daily is cancer. Globally, there has been a significant rise in cancer cases—19.3 million in...
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Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases
BackgroundNeuroinflammatory processes have been suggested to play a role in the pathophysiology of neurodegenerative diseases and post-hemorrhagic...
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The omics era: a nexus of untapped potential for Mendelian chromatinopathies
The OMICs cascade describes the hierarchical flow of information through biological systems. The epigenome sits at the apex of the cascade, thereby...
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Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention
Multiomic profiling can reveal population heterogeneity for both health and disease states. Obesity drives a myriad of metabolic perturbations and is...
