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New prospects of cancer therapy based on pyroptosis and pyroptosis inducers
Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules....
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Purinergic P2X Receptors as Therapeutic Targets
Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across membranes. P2X receptors are assembled as trimers from three...
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The Role of Necroptosis in Cerebral Ischemic Stroke
Cerebral ischemia, also known as ischemic stroke, accounts for nearly 85% of all strokes and is the leading cause of disability worldwide. Due to...
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Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients
AbstractFor over a year, the coronavirus disease 2019 has been affecting the world population by causing severe tissue injuries and death in infected...
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Purinergic Signaling Within the Tumor Microenvironment
Accumulating studies have clearly demonstrated high concentrations of extracellular ATP (eATP) within the tumor microenvironment (TME). Implications...
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Inflammasome Activation in Gingival Epithelial Cells
Inflammasomes are multiprotein complexes that assemble in host cells upon recognition of infection or danger via pattern recognition receptors and/or...
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Physical exercise as a modulator of the purinergic system in the control of sarcopenia in individuals with chronic kidney disease on hemodialysis
The word sarcopenia derives from the Greek terms “sarx” for meat and “penia” for loss, thus being used to define reductions in muscle mass, muscle...
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Purinergic interplay between erythrocytes and platelets in diabetes-associated vascular dysfunction
Cardiovascular complications in diabetes are the leading causes for high morbidity and mortality. It has been shown that alteration of purinergic...
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Drugging the efferocytosis process: concepts and opportunities
The daily removal of billions of apoptotic cells in the human body via the process of efferocytosis is essential for homeostasis. To allow for this...
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Exercise Induced NO Modulation in Prevention and Treatment of Cardiovascular Diseases
Many aspects of modern life, including lack of physical activity, contribute to the primacy of cardiovascular disease as a cause of death worldwide....
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The Role of ATP Receptors in Pain Signaling
Since new roles of nucleotides as neurotransmitters were proposed by Geoffrey Burnstock, the roles of ATP and P2 receptors (P2Rs) have been...
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Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis
Atherosclerosis is the main pathological basis of cardiovascular disease and involves damage to vascular endothelial cells (ECs) that results in...
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The purinergic signalling and inflammation in the pathogenesis and progression of diabetes: key factors and therapeutic targets
Type 2 diabetes mellitus (T2DM) is an important chronic disease around the world, and according to the World Health Organization, it is the 9th...
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P2X7 Receptor: an Emerging Target in Alzheimer’s Disease
Alzheimer’s disease (AD) is a major cause of age-related dementia, which is becoming a global health crisis. However, the pathogenesis and etiology...
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Burnstock oration — purinergic signalling in kidney transplantation
Kidney transplantation is the preferred treatment for individuals with kidney failure offering improved quality and quantity of life. Despite...
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The Pannexin-1 Channel Inhibitor Probenecid Attenuates Skeletal Muscle Cellular Energy Crisis and Histopathological Injury in a Rabbit Endotoxemia Model
This study aimed to investigate the effect of probenecid (Pro) as an inhibitor of the pannexin-1 (Panx-1) channel-mediated release of intracellular...
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Purinergic signaling in myocardial ischemia–reperfusion injury
Purines and their derivatives, extensively distributed in the body, act as a class of extracellular signaling molecules via a rich array of...
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Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia–Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models
Pyroptosis is a newly identified lytic form of programmed cell death which is characterized by plasma membrane blebbing and rupture. Pyroptosis...
