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Salivary Proteomic Analysis of Canine Oral Melanoma by MALDI-TOF Mass Spectrometry and LC-Mass Spectrometry/Mass Spectrometry
Canine oral melanoma (COM) is a common oral cancer with aggressiveness and high metastasis. A tumor in a dog’s mouth makes it difficult to be...
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The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells
AbstractAcidosis characterizes the microenvironment of most solid tumors and is considered a new hallmark of cancer. It is mainly caused by both...
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Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma
Personal neoantigen vaccines have been envisioned as an effective approach to induce, amplify and diversify antitumor T cell responses. To define the...
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Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy
Activation of PI3K/AKT pathway is one of the most recurrent resistant mechanisms for BRAF-targeted therapy, and the combination of MAPK and PI3K/AKT...
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A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway
BackgroundFyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies...
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Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways
BackgroundThe abnormal expression of circular RNAs (circRNAs) in uveal melanoma (UM) has been revealed, but the specific underlying molecular...
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Effect of EphA2 knockdown on melanoma metastasis depends on intrinsic ephrinA1 level
PurposeUpregulation of receptor tyrosine kinase EphA2 has been found to be associated with a poor prognosis in many types of cancer and is considered...
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PLGA-PEI nanoparticle covered with poly(I:C) for personalised cancer immunotherapy
Melanoma is the main cause of death among skin cancers and its incidence worldwide has been experiencing an appalling increase. However, traditional...
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High-Throughput Identification of miRNA–Target Interactions in Melanoma Using miR-CATCHv2.0
MicroRNAs (miRNAs) can regulate the expression of potentially every transcript in the cell, and the definition of miRNA–target interactions is...
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ERK3 is transcriptionally upregulated by ∆Np63α and mediates the role of ∆Np63α in suppressing cell migration in non-melanoma skin cancers
Backgroundp63, a member of the p53 gene family, is an important regulator for epithelial tissue growth and development. ∆Np63α is the main isoform of...
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Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results
There is a critical need for effective treatments for leptomeningeal disease (LMD). Here, we report the interim analysis results of an ongoing...
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Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy
Although immunotherapy has revolutionized cancer treatment, only a subset of patients demonstrate durable clinical benefit. Definitive predictive...
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Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells
BackgroundCirculating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive,...
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Therapeutic inhibition of microRNA-21 (miR-21) using locked-nucleic acid (LNA)-anti-miR and its effects on the biological behaviors of melanoma cancer cells in preclinical studies
BackgroundMelanoma is a cancer that has a high mortality rate in the absence of targeted therapy. Conventional therapies such as surgery,...
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BRAFi induced demethylation of miR-152-5p regulates phenotype switching by targeting TXNIP in cutaneous melanoma
Treatment of advanced BRAF V600 -mutant melanoma using BRAF inhibitors (BRAFi) eventually leads to drug resistance and selects for highly metastatic...
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T-type calcium channel inhibition restores sensitivity to MAPK inhibitors in de-differentiated and adaptive melanoma cells
BackgroundDrug resistance remains as one of the major challenges in melanoma therapy. It is well known that tumour cells undergo phenotypic switching...
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A method for predicting drugs that can boost the efficacy of immune checkpoint blockade
Combination therapy is a promising therapeutic strategy to enhance the efficacy of immune checkpoint blockade (ICB); however, predicting drugs for...
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Factor of time in dendritic cell (DC) maturation: short-term activation of DCs significantly improves type 1 cytokine production and T cell responses
Dendritic cells (DCs) have been intensively studied in correlation to tumor immunology and for the development DC-based cancer vaccines. Here, we...
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DEHP (di(2-ethylhexyl)phthalate) stimulates skin pigmentation by perturbing cytoskeletal homeostasis
Phthalates are extensively employed plasticizers crucial for conferring flexibility and plasticity to polyvinyl chloride. Phthalates, including DEHP...
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Cancer/testis antigens expression during cultivation of melanoma and soft tissue sarcoma cells
BackgroundAutologous dendritic cells (DC) loaded with tumor-associated antigens (TAAs) are a promising approach for anticancer immunotherapy....
