Search
Search Results
-
DNA methylation QTL map** across diverse human tissues provides molecular links between genetic variation and complex traits
Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-specific characterization of DNAm is needed to understand its...
-
TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer
T cells play a crucial role in adaptive immunity by recognizing and eliminating foreign pathogens and abnormal cells such as cancer cells. T cell...
-
The Role of Beta2-Microglobulin in Central Nervous System Disease
Central nervous system (CNS) disorders represent the leading cause of disability and the second leading cause of death worldwide, and impose a...
-
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment
Pluripotent stem cells (PSCs) are a promising source of allogeneic T cells for off-the-shelf immunotherapies. However, the process of differentiating...
-
Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications
Mucosal-associated invariant T (MAIT) cells are an atypical subset of T lymphocytes, which have a highly conserved semi-constant αβ chain of T-cell...
-
Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases
Major histocompatibility complex (MHC) class II molecules play a crucial role in immunity by presenting peptide antigens to helper T cells. Immune...
-
Immunological and genomic characterization of Ibizan Hound dogs in an endemic Leishmania infantum region
BackgroundThe Ibizan Hound is a canine breed native to the Mediterranean region, where leishmaniosis is an endemic zoonosis. Several studies indicate...
-
Calreticulin: a quintessential multifaceted protein with therapeutic potential
Calreticulin is primarily an endoplasmic reticulum (ER) resident protein which has also been identified at different cellular sites. Its...
-
Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus
Owing to the immunogenicity of adeno-associated viruses (AAVs), gene therapies using AAVs face considerable obstacles. Here, by leveraging ex vivo...
-
Central nervous system-associated macrophages modulate the immune response following stroke in aged mice
Age is a major nonmodifiable risk factor for ischemic stroke. Central nervous system-associated macrophages (CAMs) are resident immune cells located...
-
Mirror-Image Pain Update: Complex Interactions Between Central and Peripheral Mechanisms
The appearance of contralateral effects after unilateral injury has been shown in various experimental pain models, as well as in clinics. They...
-
The Immunogenetics of Vasculitis
Vasculitides are a cluster of diseases defined by an immune attack targeting vessels of different sizes. While most types of vasculitis have an...
-
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
BackgroundParkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn)...
-
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation
LAG3 is an inhibitory receptor that is highly expressed on exhausted T cells. Although LAG3-targeting immunotherapeutics are currently in clinical...
-
Genome-Based Bioinformatic Prediction of Major Histocompatibility (MHC)
Over the last 17 years, a large amount of knowledge has been accumulated on various aspects of major histocompatibility complex (MHC) molecules. In...
-
A novel 4 immune-related genes as diagnostic markers and correlated with immune infiltrates in major depressive disorder
BackgroundImmune response is prevalently related with major depressive disorder (MDD) pathophysiology. However, the study on the relationship between...
-
Quantitative proteomic analysis of local and systemic extracellular vesicles during Eimeria falciformis infectious cycle in the host
BackgroundExtracellular vesicles (EVs) are membranous structures that are formed during pathophysiology, host-parasite interactions and parasite...
-
MHCtools 1.5: Analysis of MHC Sequencing Data in R
The genes of the major histocompatibility complex (MHC) play a vital role in the vertebrate immune system and have attracted considerable interest in...
-
I-Ag7 β56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes
Genetic susceptibility to type 1 diabetes is associated with homozygous expression of major histocompatibility complex class II alleles that carry...
-
Reverse Genetics of Bat Influenza A Viruses
New World fruit bats were recently found to harbor two distinct and previously unknown influenza A viruses (IAVs) of the subtypes H17N10 and H18N11....