Search
Search Results
-
Successful Immune Reconstitution in a Patient with a TYK2 Deficiency after Allogeneic Stem Cell Transplantation from Unrelated Donors
A boy with primary immunodeficiency, caused by a tyrosine kinase 2 ( TYK2 ) mutation, presented with immune defects and a lifelong history of severe...
-
Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway
Ex vivo culture-amplified mesenchymal stem cells (MSCs) have been studied because of their capacity for healing tissue injury. MSC transplantation is...
-
Respiratory Delivery of Probiotics to Improve Lung Health
Increasing evidence suggests that the lung microbiome is essential for maintaining lung health and homeostasis. Although causality has not been...
-
Rational engineering of lung alveolar epithelium
Engineered whole lungs may one day expand therapeutic options for patients with end-stage lung disease. However, the feasibility of ex vivo lung...
-
Fetal Lung Tissue Engineering
Lung transplantation may be considered as a final treatment option for diseases such as chronic lung disease, pulmonary hypertension,...
-
Hypoxia-inducible factor 1α modulates interstitial pneumonia-mediated lung cancer progression
BackgroundThe prognosis of patients with lung cancer accompanied by interstitial pneumonia is poorer than that of patients with lung cancer but...
-
Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury
BackgroundThe gut microbiota plays a critical role in regulating brain function through the microbiome-gut-brain axis (MGBA). Dysbiosis of the gut...
-
The question of screening organ donors for hepatitis e virus: a case report of transmission by kidney transplantation in France and a review of the literature
BackgroundHepatitis E is a potentially serious infection in organ recipients, with an estimated two-thirds of cases becoming chronic, and with a...
-
Lung Extracellular Matrix as a Platform for Lung Organ Bioengineering: Design and Development of Tissue Engineered Lung
Since lung tissue is not able to be reconstructed after substantial injury, lung transplantation often is the only alternative for treatment....
-
Cognitive Function After Lung Transplantation
Cognitive functioning after transplantation, which could influence medication compliance and independence, has not been well studied. This study...
-
Lactate exacerbates lung damage induced by nanomicroplastic through the gut microbiota–HIF1a/PTBP1 pathway
Exposure to nanomicroplastics (nano-MPs) can induce lung damage. The gut microbiota is a critical modulator of the gut–lung axis. However, the...
-
CXCR4 enhances the inhibitory effects of bone mesenchymal stem cells on lung cell apoptosis in a rat model of smoking-induced COPD
Chronic obstructive pulmonary disease is the 3rd leading cause of death worldwide, and the available treatments are unsatisfactory, resulting in a...
-
Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
Epigenetic alterations, especially histone methylation, are key factors in cell migration and invasion in cancer metastasis. However, in lung cancer...
-
Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation
Interferon-γ (IFN-γ) is an important cytokine in tissue homeostasis and immune response, while studies about it in antibody-mediated rejection (ABMR)...
-
Cost-effectiveness analysis of CYP3A5 genotype-guided tacrolimus dosing in solid organ transplantation using real-world data
The objective of this study was to estimate the cost-effectiveness of CYP3A5 genotype-guided tacrolimus dosing in kidney, liver, heart, and lung...
-
Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment
Chronic lung diseases include an array of conditions that impact airways and lung structures, leading to considerable societal burdens. Mesenchymal...
-
The Interplay of the Renin-Angiotensin System and Solid Organ Transplantation
The renin-angiotensin system (RAS) plays a powerful role in controlling sodium balances, fluid body volumes, and arterial pressures. New studies...
-
Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model
BackgroundOff-the-shelf major histocompatibility complex (MHC)-matched iPS cells (iPSC) can potentially initiate host immune responses because of the...
-
Noggin contributes to brain metastatic colonization of lung cancer cells
BackgroundBrain metastasis is a common complication among patients with lung cancer, yet the underlying mechanisms remain unclear. In this study, we...
-
Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease
BackgroundInterstitial lung disease (ILD) is the primary cause of mortality in systemic sclerosis (SSc), an autoimmune disease characterized by...
