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High incidence of thromboembolism in patients with chronic GVHD: association with severity of GVHD and donor-recipient ABO blood group
Chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic cell transplantation (HCT) is associated with systemic inflammation and...
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Relationship Between Change Rate of Tacrolimus Clearance During Continuous Intravenous Infusion and Recipient Recovery at an Early Stage After Living Donor Liver Transplantation
Background and ObjectiveTacrolimus clearance (CL) is significantly altered according to recovery of liver function at an early stage after living...
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Monoclonal Antibodies in Solid Organ Transplantation
In an attempt to target solid organ transplant immunosuppression, monoclonal antibodies directed against key steps in specific immunologic pathways...
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Liver-resident memory T cells: life in lockdown
A subset of memory T cells has been identified in the liver with a tissue-resident profile and the capacity for long-term ‘lockdown’. Here we review...
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Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease
Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD), are rising in both incidence and prevalence and remain...
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Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas
The pathogenesis of allograft (dys)function has been increasingly studied using ‘omics’-based technologies, but the focus on individual organs has...
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Organ Toxicity by Immunosuppressive Drugs in Solid Organ Transplantation
Solid organ transplantation is the preferred therapeutic option that confers significant survival advantage on patients suffering from end-organ...
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PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation
To optimize outcomes in solid organ transplantation, the HLA genes are regularly compared and matched between the donor and recipient. However, in...
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Fatal Pandoraea nosoerga infection after combined liver-lung transplantation for cystic fibrosis: a recontamination by the pre-transplantation strain
A 26-year-old girl with a longstanding colonization by Pandoraea nosoerga underwent liver-lung transplantation for cystic fibrosis (CF) in 2018. Her...
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Treprostinil Supplementation Ameliorates Hepatic Ischemia Reperfusion Injury and Regulates Expression of Hepatic Drug Transporters: An Isolated Perfused Rat Liver (IPRL) Study
PurposeIR injury is an unavoidable consequence in deceased donor liver transplantation. Cold preservation and warm reperfusion may change the...
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The Biology and Molecular Basis of Organ Transplant Rejection
Allograft rejection is defined as tissue injury in a transplanted allogeneic organ produced by the effector mechanisms of the adaptive alloimmune...
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Highly individual- and tissue-specific expression of glycoprotein group A and B blood antigens in the human kidney and liver
BackgroundCurrently, research on the quantitative distribution of ABO antigens in different organs and tissues remains limited. We aimed to examine...
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Clinical Manifestations of Hepatitis E
The clinical manifestations of hepatitis E are similar to those of other types of viral hepatitis. While acute hepatitis E is usually self-limited,...
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Methods of ex vivo analysis of tissue status in vascularized composite allografts
Vascularized composite allotransplantation can improve quality of life and restore functionality. However, the complex tissue composition of...
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The Pursuit of Regulatory T Cells in the Induction of Transplant Tolerance
Organ transplantation is a preferred treatment option for patients with end-stage organ failure. However, transplant induces a robust rejection...
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Management of Transplant Patients Infected with HCV
Hepatitis C virus (HCV) infection is a leading cause of cirrhosis and hepatocellular carcinoma and one of the main indications for liver...
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Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles
Liver fibrosis is the common consequence of almost all liver diseases and has become an urgent clinical problem without efficient therapies. Recent...
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In Vivo Modeling of Leukemia by Murine Stem Cell Transplantation
Murine stem cell transplantation is a well-established method for the in vivo study of leukemic pathophysiology. Adoptive transfer of murine leukemic...