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Intimate communications within the tumor microenvironment: stromal factors function as an orchestra
Extensive studies of the tumor microenvironment (TME) in the last decade have reformed the view of cancer as a tumor cell-centric disease. The tumor...
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The nexus of natural killer cells and melanoma tumor microenvironment: crosstalk, chemotherapeutic potential, and innovative NK cell-based therapeutic strategies
The metastasis of melanoma cells to regional lymph nodes and distant sites is an important contributor to cancer-related morbidity and mortality...
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Nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer
BackgroundAs of 2020, hepatocellular carcinoma (HCC), a form of liver cancer, stood as the third most prominent contributor to global cancer-related...
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Glia Signaling and Brain Microenvironment in Migraine
Migraine is a complicated neurological disorder affecting 6% of men and 18% of women worldwide. Various mechanisms, including neuroinflammation,...
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Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products
During carcinogenesis, the microenvironment plays a fundamental role in tumor progression and resistance. This tumor microenvironment (TME) is...
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Crosstalk and plasticity driving between cancer-associated fibroblasts and tumor microenvironment: significance of breast cancer metastasis
Cancer-associated fibroblasts (CAFs) are the most abundant stromal cell population in breast tumors. A functionally diverse population of CAFs...
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Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance
The tumor microenvironment (TME) plays a pivotal role in cancer development and progression. In this line, revealing the precise mechanisms of the...
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Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics
Cancer is a disease that undergoes selective pressure to evolve during its progression, becoming increasingly heterogeneous. Tumoral heterogeneity...
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Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment
Ferroptosis, a novel form of cell death triggered by iron-dependent phospholipid peroxidation, presents significant therapeutic potential across...
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Macrophage Polarization in the Tumor Microenvironment: Modulation and Mimicry
Macrophages are innate immune cells that dominate the tumor microenvironment. Environmental cues polarize tumor-associated macrophages (TAMs) into...
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Androgen Signaling in the Tumor Microenvironment
The key function of mesenchymal/stromal androgen receptor (AR) signaling for prostate development has been well documented by tissue recombination...
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LSD1: an emerging face in altering the tumor microenvironment and enhancing immune checkpoint therapy
Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive tumor growth. In combination...
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The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?
The efficacy of cancer immunotherapy largely depends on the tumor microenvironment, especially the tumor immune microenvironment. Emerging studies...
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Epigenetic regulation and therapeutic targets in the tumor microenvironment
The tumor microenvironment (TME) is crucial to neoplastic processes, fostering proliferation, angiogenesis and metastasis. Epigenetic regulations,...
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MicroRNAs Targeting Tumor Microenvironment and Immune Modulation
MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate transcriptional and translational processes. In particular, miRNAs act as...
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SUMOylation inhibitors activate anti-tumor immunity by resha** the immune microenvironment in a preclinical model of hepatocellular carcinoma
PurposeHigh levels of heterogeneity and immunosuppression characterize the HCC immune microenvironment (TME). Unfortunately, the majority of...
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CXCL11 Signaling in the Tumor Microenvironment
CXCL11 which can bind to two different chemokine receptors, CXCR3 and CXCR7, has found a prominent place in current tumor research. In this chapter,...
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Enhanced epithelial-mesenchymal transition signatures are linked with adverse tumor microenvironment, angiogenesis and worse survival in gastric cancer
Epithelial-mesenchymal transition (EMT) is a crucial mechanism that facilitates cancer cell metastasis. Despite its importance, the clinical...
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The aged tumor microenvironment limits T cell control of cancer
The etiology and effect of age-related immune dysfunction in cancer is not completely understood. Here we show that limited priming of CD8 + T cells...
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Progesterone Receptor Signaling in the Breast Tumor Microenvironment
The tumor microenvironment (TME) is a complex infrastructure composed of stromal, epithelial, and immune cells embedded in a vasculature ECM. The...