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The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
Aluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer’s disease (AD). We uesd a...
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Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice
BackgroundSirtuin 1 ( Sirt1 ) is a recognized longevity gene and has been shown to be associated with aging and its related diseases. Hippocampal...
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The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy
Targeted tissue ablation involving the anterior hippocampus is the standard of care for patients with drug-resistant mesial temporal lobe epilepsy....
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Nicorandil Exerts Anticonvulsant Effects in Pentylenetetrazol-Induced Seizures and Maximal-Electroshock-Induced Seizures by Downregulating Excitability in Hippocampal Pyramidal Neurons
N-(2-hydroxyethyl) nicotinamide nitrate (nicorandil), a nitrate that activates adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channels, is...
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Role of hippocampal location and radiation dose in glioblastoma patients with hippocampal atrophy
BackgroundThe hippocampus is a critical organ for irradiation. Thus, we explored changes in hippocampal volume according to the dose delivered and...
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Inhibitory control of sharp-wave ripple duration during learning in hippocampal recurrent networks
Recurrent excitatory connections in hippocampal regions CA3 and CA2 are thought to play a key role in the generation of sharp-wave ripples (SWRs),...
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Intra-hippocampal cis-P tau microinjection induces long-term changes in behavior and synaptic plasticity in mice
BackgroundAlzheimer's disease is accompanied by an abnormal high accumulation of cis-P tau. However, the long-term changes in behavior following tau...
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A nonhuman primate model with Alzheimer’s disease-like pathology induced by hippocampal overexpression of human tau
BackgroundAlzheimer’s disease (AD) is one of the most burdening diseases of the century with no disease-modifying treatment at this time. Nonhuman...
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Effect of Early Inhibition of Toll-Like Receptor 4 on Hippocampal Plasticity in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage
Hippocampal plasticity is closely related to physiological brain functions such as learning and memory. However, the effect of toll-like receptor 4...
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Effects of Suppression of Glycolysis on the Ultrastructure of Giant Hippocampal Synapses
Suppression of glycolysis in the hippocampal formation was induced in rats by daily administration of 2-deoxy-D-glucose into the lateral ventricles...
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The Role and Mechanism of Ambra1-Mediated Mitophagy in TDCPP-Exposed Mouse Hippocampal Neurons
Tri(1,3-dichloro-2-propyl)phosphate (TDCPP) is one of the most widely used organophosphorus flame retardants in consumer products. TDCPP has been...
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The role of inhibitory circuits in hippocampal memory processing
GABAergic inhibitory circuits play an essential role in coordinating various hippocampal functions. Several decades of work dedicated to a thorough...
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Cilostazol pretreatment prevents PTSD-related anxiety behavior through reduction of hippocampal neuroinflammation
Current pharmacological treatments against post-traumatic stress disorder (PTSD) lack adequate efficacy. As a result, intense research has focused on...
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Doxycycline reversal of amphetamine-induced mania-like behavior is related to adjusting brain monoamine abnormalities and antioxidant effects in primary hippocampal neurons
Mania is associated with disturbed dopaminergic transmission in frontotemporal regions. D-amphetamine (AMPH) causes increased extracellular DA...
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The Role of the Dentate Gyrus in Mediating Hippocampal Functions: The Epileptic Brain
Temporal lobe epilepsy (TE) is characterized by loss of hippocampal cells, often leading to hippocampal sclerosis, subsequent reorganization of the...
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Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome
BackgroundIt is well known that high-fat diet (HFD)-induced metabolic syndrome plays a crucial role in cognitive decline and brain-blood barrier...
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Activation of the Hippocampal DRD2 Alleviates Neuroinflammation, Synaptic Plasticity Damage and Cognitive Impairment After Sleep Deprivation
Sleep loss is commonplace nowadays and profoundly impacts cognition. Dopamine receptor D2 (DRD2) makes a specific contribution to cognition, although...
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Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice
Aging is one of the main risk factors for cognitive dysfunction. During aging process, the decrease of brain-derived neurotrophic factor (BDNF) and...
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Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information
As a main structure of the limbic system, the hippocampus plays a critical role in pain perception and chronicity. The ventral hippocampal CA1 (vCA1)...
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The Role of the Dentate Gyrus in Mediating Hippocampal Functions: The Healthy Brain
The dentate gyrus (DG), which is part of the hippocampal formation, is the main target of neocortical and subcortical afferents received by the...