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Strategies to prevent drug incompatibility during simultaneous multi-drug infusion in intensive care units: a literature review
PurposeDrug protocols in intensive care units may require the concomitant administration of many drugs as patients’ venous accesses are often...
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How the Global COVID-19 Pandemic Brought Drug and Vaccine Development into the Public Mainstream
Pharmaceutical development was at the forefront of efforts to prevent infection with the SARS-CoV-2 virus as well as to treat its often-devastating...
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Nano Drug Delivery Approaches for Lymphatic Filariasis Therapeutics
Engineering and crafting of a functional system at the molecular level is coined as nanotechnology, ranging in the scale of 0.1–100 nm. This range of...
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Arginine regulates HSPA5/BiP translation through ribosome pausing in triple-negative breast cancer cells
BackgroundTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a high mortality rate due to a lack of therapeutic...
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Asymptomatic nasopharyngeal bacterial carriage, multi-drug resistance pattern and associated factors among primary school children at Debre Berhan town, North Shewa, Ethiopia
BackgroundNasopharyngeal carriage of bacteria is the main source for transmission of pathogens across individuals and horizontal spread of organisms...
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Policies to improve access to pharmaceutical products in shortage: the experience of Iran food and drug administration
BackgroundIn the past decades, economic sanctions imposed on Iran for its nuclear program. The embargo made difficulty in foreign trade and led to...
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Nitroso Impurities in Drug Products: An Overview of Risk Assessment, Regulatory Milieu, and Control Strategy
Many nitrosamines have been recognized to be carcinogenic for many decades. Despite the fact that several nitrosamine precursors are frequently used...
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Avidity in antibody effector functions and biotherapeutic drug design
Antibodies are the cardinal effector molecules of the immune system and are being leveraged with enormous success as biotherapeutic drugs. A key part...
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Recent Update on Nanomedicine-Based Drug Targeting on Colon Cancer
Colorectal cancer (CRC) is a major cause of mortality and highly prevalent worldwide. Currently, no effective delivery system is available for...
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Interfaces in Protein Drug Delivery: Device Concern
Effective oral delivery is difficult for many protein drugs, as high-molecular-weight proteins do not easily cross the mucosal membrane and...
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New Drug Discovery and Development in India to Counter Malaria
As India sets its sight on malaria elimination, using tools for vector control, protection, diagnosis, and treatment, it is important to look at the...
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Temporal trends in molecular markers of drug resistance in Plasmodium falciparum in human blood and profiles of corresponding resistant markers in mosquito oocysts in Asembo, western Kenya
BackgroundOver the last two decades, the scale-up of vector control and changes in the first-line anti-malarial, from chloroquine (CQ) to...
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The Concept of Medicines Shortage: Identifying and Resolving Shortage
It is not easy to find out when scientific researches concerning shortage (scarcity) were started. In the field of first studies, authors revised...
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K Channel Openers as New Antiarrhythmic Agents
Cardiac cation channels are membrane proteins that provide controlled ion passage through cellular membranes to allow electrical control of the...
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Protein Crystallization in Space and Its Contribution to Drug Development
It has been a long time since space experiments have been conducted to produce protein crystals in microgravity. High-quality crystals grown in space...
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Benchmarking the Quality Practices of Global Pharmaceutical Manufacturing to Advance Supply Chain Resilience
Over the past several decades, pharmaceutical manufacturing has become increasingly global and supply chains have become longer, more complex, and...
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International assessment results on non-NIOSH approved respirators by the national personal protective technology laboratory (NPPTL): a data note
ObjectivesDue to the COVID-19 pandemic and the shortage of the National Institute for Occupational Safety & Health (NIOSH)-approved N95 respirators,...
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Deciphering the Role of Nanomedicines for the Treatment of Ischemic Stroke
Ischemic stroke (IS) affects 15 million people globally which leads to death or disability. Currently, Tissue plasminogen activator (tPA) is the only...
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Role of Artificial Intelligence in Pharmacovigilance
Pharmacovigilance ensures the safety and efficacy of any pharmaceutical drug products or medical devices throughout their lifecycle. Traditional...