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Deciphering the Role of Nanomedicines for the Treatment of Ischemic Stroke

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Theranostic Applications of Nanotechnology in Neurological Disorders

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Abstract

Ischemic stroke (IS) affects 15 million people globally which leads to death or disability. Currently, Tissue plasminogen activator (tPA) is the only medication approved by the US Food and Drug Administration (FDA) for treating IS. This treatment eliminates the brain’s blood shortage and the reperfusion-related adverse effects that cause significant tissue damage. Therefore, novel treatment approaches are urgently needed to preserve the integrity of the blood-brain barrier (BBB) and salvageable brain tissue. Nanomedicine opens a new door for emerging strategies that can be promising therapeutic approaches for IS. This chapter first discusses the pathophysiology and different events of IS, then available therapeutic interventions for IS followed by different nanocarriers available. This chapter also covers viral vectors and extracellular vesicles for IS. Also, it focuses on the intranasal administration of nanomedicines, which might cross the BBB and finally discusses toxicity related to nanocarriers for IS. This chapter is completely focused on using nanomedicines for the use of IS.

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Authors and Affiliations

  1. Department of Medical Elementology and Toxicology, Jamia Hamdard University, Delhi, India

    Faizan Ahmad

  2. CL Lab LLC, Gaithersburg, MD, USA

    Anik Karan

  3. Department of Surgery Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Centre, Omaha, NE, USA

    Navatha Shree Sharma

  4. Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA

    Vaishnavi Sundar

  5. Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE

    Richard Jayaraj

  6. IDRP, Indian Institute of Technology, Jodhpur, Rajasthan, India

    Umme Abiha

  7. All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

    Umme Abiha

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  1. Center for Neural and Cognitive Sciences, University of Hyderabad, Hyderabad, Telangana, India

    Akash Gautam

  2. Department of Physics, University of Delhi, New Delhi, Delhi, India

    Vishal Chaudhary

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Ahmad, F., Karan, A., Sharma, N.S., Sundar, V., Jayaraj, R., Abiha, U. (2023). Deciphering the Role of Nanomedicines for the Treatment of Ischemic Stroke. In: Gautam, A., Chaudhary, V. (eds) Theranostic Applications of Nanotechnology in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-99-9510-3_9

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