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The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts cognitive deficits induced by the D1/D2 dopaminergic receptor agonist apomorphine in rats
RationaleSchizophrenia is a devastating mental disease that affects nearly 1% of the population worldwide. It is well documented that the...
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Dopamine D2 receptors in the expression and extinction of contextual and cued conditioned fear in rats
Dopamine seems to mediate fear conditioning through its action on D2 receptors in the mesolimbic pathway. Systemic and local injections of...
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The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson’s Disease
The adenosine A 2A receptor (A 2A R), dopamine D 2 receptor (D 2 R) and metabotropic glutamate receptor type 5 (mGluR 5 ) form A 2A R-D 2 R-mGluR 5 heteroreceptor...
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Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons
Medium spiny neurons (MSNs) in the striatum, which can be divided into D1 and D2 MSNs, originate from the lateral ganglionic eminence (LGE)....
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Receptor-Binding Specificity of Influenza Viruses
Influenza A virus infection begins with the attachment of virus particles to sialic acid-containing receptors on the surface of host cells. This...
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Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors
Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to...
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Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors
Depression and anxiety are more common among females than males and represent a leading cause of disease-related disability in women. Since the...
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Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo
Noninvasive quantitative imaging of beta-cells can provide information on changes in cellular transporters, receptors, and signaling proteins that...
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Projections from D2 Neurons in Different Subregions of Nucleus Accumbens Shell to Ventral Pallidum Play Distinct Roles in Reward and Aversion
The nucleus accumbens shell (NAcSh) plays an important role in reward and aversion. Traditionally, NAc dopamine receptor 2-expressing (D2) neurons...
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Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor–Receptor Interaction and Striatal Function
G protein-coupled receptors (GPCR) heterodimers represent new entities with unique pharmacological, signalling, and trafficking properties, with...
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Dopamine Receptor Supersensitivity and Schizophrenia
Despite decades of clinical and preclinical research, the etiopathology of schizophrenia remains unknown. One of the most long-standing theories...
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Molecular and Structural Insight into Adenosine A2A Receptor in Neurodegenerative Disorders: A Significant Target for Efficient Treatment Approach
All biological tissues and bodily fluids include the autacoid adenosine. The P1 class of purinergic receptors includes adenosine receptors. Four...
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Prefrontal allopregnanolone synergizes with D1 receptor activation to disrupt sensorimotor gating in male Sprague-Dawley rats
Abstract RationaleThe prepulse inhibition (PPI) of the startle reflex is the best-established index of sensorimotor gating. We documented that the...
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The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity
The Disrupted in schizophrenia 1 ( DISC1 ) gene encodes a scaffolding protein that is involved in many neural functions such as neurogenesis, neural...
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Dopamine D2 Receptor-Mediated Modulation of Rat Retinal Ganglion Cell Excitability
Ganglion cells (RGCs) are the sole output neurons of the retinal circuity. Here, we investigated whether and how dopamine D2 receptors modulate the...
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Molecular characterization and distribution of motilin and motilin receptor in the Japanese medaka Oryzias latipes
Motilin (MLN) is a peptide hormone originally isolated from the mucosa of the porcine intestine. Its orthologs have been identified in various...
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Initial characterization of a transgenic mouse with overexpression of the human D1-dopamine receptor in the heart
Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase...
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Endothelin-1-mediated Brainstem Glial Activation Produces Asthmatic Airway Vagal Hypertonia Via Enhanced ATP-P2X4 Receptor Signaling in Sprague–Dawley Rats
The occurrence of major asthma symptoms is largely attributed to airway vagal hypertonia, of which the central mechanisms remain unclear. This study...
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Effort-related effects of chronic administration of the DA D2 receptor antagonist haloperidol via subcutaneous programmable minipumps: Reversal by co-administration of the adenosine A2A antagonist istradefylline
RationaleLong-acting antipsychotics such as haloperidol decanoate are becoming more commonly used. Long-acting depot formulations have several...
