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Activation of Lateral Parabrachial Nucleus (LPBn) PACAP-Expressing Projection Neurons to the Bed Nucleus of the Stria Terminalis (BNST) Enhances Anxiety-like Behavior
Anxiety disorders are among the most common psychiatric disorders, and understanding the underlying neurocircuitry of anxiety- and stress-related...
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The Central Core of the Brain
The central core is an ovoid shaped region at the morphological center of each cerebral hemisphere and its structures display a different pattern of...
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Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons
The nucleus tractus solitarii (NTS) is one of the morphologically and functionally defined centers that engage in the autonomic regulation of...
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Populational heterogeneity and partial migratory origin of the ventromedial hypothalamic nucleus: genoarchitectonic analysis in the mouse
The ventromedial hypothalamic nucleus (VMH) is one of the most distinctive hypothalamic tuberal structures, subject of numerous classic and modern...
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Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleus
Patients with Parkinson’s disease often complain of excessive daytime sleepiness which negatively impacts their quality of life. The pedunculopontine...
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Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration
Ageing is associated with altered neuroendocrine function. In the context of the hypothalamic supraoptic nucleus, which makes the antidiuretic...
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Activation AMPK in Hypothalamic Paraventricular Nucleus Improves Renovascular Hypertension Through ERK1/2-NF-ÎşB Pathway
Hypertension is a globally prevalent disease, but the pathogenesis remains largely unclear. AMP-activated protein kinase (AMPK) is a...
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Lymphomas of Central Nervous System
Central nervous systemCentral nervous system (CNS) (CNS) lymphoma consists of primary central nervous system lymphomaPrimary Central Nervous System...
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Central Neuroendocrine Control of the Cardiovascular System
The paraventricular nucleus (PVN) is a pivotal central structure involved in neuroendocrine cardiovascular regulation. The main PVN effects on blood...
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Role of NMDA receptors blockade in the thalamic paraventricular nucleus in morphine dependent rat model of formalin-induced pain
Evidence shows that the N-methyl- d -aspartate (NMDA) antagonist MK801 reduces the development of morphine (Mor) tolerance. The paraventricular nucleus...
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Integrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors
Major depressive disorder represents a serious public health challenge worldwide; however, the underlying cellular and molecular mechanisms are...
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Nucleus Reuniens: Circuitry, Function, and Dysfunction
The nucleus reuniens (RE) of the ventral midline thalamus is intimately connected with forebrain structures involved in higher-order functions and...
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Control of Emotion and Wakefulness by Neurotensinergic Neurons in the Parabrachial Nucleus
The parabrachial nucleus (PBN) integrates interoceptive and exteroceptive information to control various behavioral and physiological processes...
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Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice
Anxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have...
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Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus
The paraventricular nucleus of the thalamus (PVT) projects to areas of the forebrain involved in regulating behavior. Homeostatic challenges and...
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Nucleus reticularis tegmenti pontis: a bridge between the basal ganglia and cerebellum for movement control
Neural processing in the basal ganglia is critical for normal movement. Diseases of the basal ganglia, such as Parkinson’s disease, produce a variety...
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Thalamic Nucleus Reuniens Glutamatergic Neurons Mediate Colorectal Visceral Pain in Mice via 5-HT2B Receptors
Irritable bowel syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity. Reducing visceral...
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TLR2 Mediates Microglial Activation and Contributes to Central Sensitization in a Recurrent Nitroglycerin-induced Chronic Migraine Model
Central sensitization is an important pathophysiological mechanism underlying chronic migraine (CM). Previous studies have shown that microglial...
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Pyridostigmine attenuates hypertension by inhibiting activation of the renin-angiotensin system in the hypothalamic paraventricular nucleus
Activation of the renin-angiotensin system (RAS) triggers oxidative stress and an inflammatory response in the hypothalamic paraventricular nucleus...
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Large-Scale Single-Nucleus RNA Sequencing Compatible with Complex Archived Samples
Transcriptome profiling at single-cell resolution allows us to identify and assess functional cell types and cellular states, including those within...