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Anomalies of Energy Metabolism in Schizophrenia and Possible Pathogenetically Targeted Therapeutic Approaches
Abstract —Coordinated regulation of energy conversion processes in the brain maintains its highly productive work and efficient mental activity....
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Iron Metabolism and Ferroptosis in Early Brain Injury after Subarachnoid Haemorrhage
At present, it appears that the prognosis for subarachnoid haemorrhage (SAH), which has a high death and disability rate, cannot be greatly improved...
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Thymidine nucleotide metabolism controls human telomere length
Telomere length in humans is associated with lifespan and severe diseases, yet the genetic determinants of telomere length remain incompletely...
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Is metabolism the magic bullet for targeted cancer therapy?
Altered cellular metabolism has long been recognized as a hallmark of cancer. Oncogenic signaling cascades induce metabolic rewiring that further...
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NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods
Identification of compounds to modulate NADPH metabolism is crucial for understanding complex diseases and develo** effective therapies. However,...
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Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major...
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Kinetic Modeling of Hepatic Metabolism and Simulation of Treatment Effects
Mathematical modeling is a promising strategy to fill the experimentally unapproachable knowledge gaps about the relative contribution of various...
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Identification of Immune Infiltration and Iron Metabolism–Related Subgroups in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with a broad spectrum of symptoms and prognoses. Effective therapy requires...
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Expression Analysis of Nitrogen Metabolism Genes in Lelliottia amnigena PTJIIT1005, Comparison with Escherichia coli K12 and Validation of Nitrogen Metabolism Genes
Escherichia coli K12 and Lelliottia amnigena PTJIIT1005 bacteria were isolated from the polluted Yamuna River (Delhi, India) site, which can...
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Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer
BackgroundThe role of cholesterol metabolism in gastric cancer (GC) and its implications for tumor characteristics and immunotherapy response remain...
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Rethinking our approach to cancer metabolism to deliver patient benefit
Altered cellular metabolism is a major mechanism by which tumours support nutrient consumption associated with increased cellular proliferation....
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Features of metabolism associated molecular patterns in pancreatic ductal adenocarcinoma
Exploring pancreatic ductal adenocarcinoma (PDAC) metabolic landscape would contribute to further understand PDAC from the metabolic perspective and...
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Targeting metabolism to enhance immunotherapy within tumor microenvironment
Cancer metabolic reprogramming has been considered an emerging hallmark in tumorigenesis and the antitumor immune response. Like cancer cells, immune...
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The Role of Iron Metabolism in Sepsis-associated Encephalopathy: a Potential Target
Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction secondary to infection, and the severity can range from mild delirium to deep...
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HDL Metabolism and Diseases
This book focuses on both high-density lipoproteins (HDL) metabolism and related diseases from the perspectives of the world-class experts in HDL....
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Leptin as a Biomarker in Nutrition and Metabolism
Obesity and its associated metabolic diseases became a major health problem and leading eventually to cardiovascular diseases and increased morbidity...
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Both Enantiomers of 2-Hydroxyglutarate Modulate the Metabolism of Cultured Human Neuroblastoma Cells
Elevated levels of D-2-hydroxyglutarate (D-2HG) and L-2-hydroxyglutarate (L-2HG) in the brain are associated with various pathological conditions,...
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Immune Cell Metabolism and Function
Immune cells are highly dynamic by nature and rely on metabolism to adapt to different conditions. Many recent studies have shown the importance of...
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Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia worldwide. Dysregulation of various...
