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Self-replicating vehicles based on negative strand RNA viruses
Self-replicating RNA viruses have been engineered as efficient expression vectors for vaccine development for infectious diseases and cancers....
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Use of Reverse Genetics for the Generation of Recombinant Influenza Viruses Carrying Nanoluciferase
Influenza A (FLUAV) and influenza B (FLUBV) viruses are human and/or animal pathogens widely studied due to their importance to public health and...
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Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses
Rabies-virus-based monosynaptic tracing is a widely used technique for map** neural circuitry, but its cytotoxicity has confined it primarily to...
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Viruses as tools in gene therapy, vaccine development, and cancer treatment
Using viruses to our advantage has been a huge leap for humanity. Their ability to mediate horizontal gene transfer has made them useful tools for...
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Viruses for Systemic Delivery
Adeno-associated virus (AAV) is a nonpathogenic virus that has been leveraged as a gene-delivery vector due to its high transduction efficiency in...
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Improved Production Strategies for Oncolytic Measles Viruses as a Therapeutic Cancer Treatment
Among the variety of currently investigated oncolytic viruses, the excellent safety record, the natural oncotropism, and the possibilities of genetic...
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Recombinant Cedar Virus: A Henipavirus Reverse Genetics Platform
The isolation of Cedar virus, a nonpathogenic henipavirus that is closely related to the highly pathogenic Nipah virus and Hendra virus, provides a...
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Poxviridae Pneumonia
Poxviridae family includes several viruses that infecting humans usually causes skin lesions only, but in some cases their clinical course is...
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Highly Sensitive Analysis of Cervical Mucosal HIV-1 Infection Using Reporter Viruses Expressing Secreted Nanoluciferase
Ex vivo cervical tissue explant models offer a physiologically relevant approach for studying virus-host interactions that underlie mucosal HIV-1...
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Post-genomic platform for development of oligonucleotide vaccines against RNA viruses: diamond cuts diamond
The coronavirus pandemic has starkly demonstrated the need to create highly effective vaccines against various viral diseases. The emerging new...
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Recent advances of engineered oncolytic viruses-based combination therapy for liver cancer
Liver cancer is a major malignant tumor, which seriously threatens human health and increases the economic burden on patients. At present, gene...
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The 3' end of the coding region of senecavirus A contains a highly conserved sequence that potentially forms a stem-loop structure required for virus rescue
Senecavirus A (SVA) can cause a vesicular disease in swine. It is a positive-strand RNA virus belonging to the genus Senecavirus in the family Picornaviridae...
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A high-throughput screening assay to identify inhibitory antibodies targeting alphavirus release
BackgroundSeveral studies have demonstrated neutralizing antibodies to be highly effective against alphavirus infection in animal models, both...
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Construction of a replication-competent retroviral vector for expression of the VSV-G envelope glycoprotein for cancer gene therapy
Gibbon ape leukemia virus (GALV) can infect a wide variety of cells but fails to infect most cells derived from laboratory mice. Transduction of...
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Harnessing adenovirus in cancer immunotherapy: evoking cellular immunity and targeting delivery in cell-specific manner
Recombinant adenovirus (rAd) regimens, including replication-competent oncolytic adenovirus (OAV) and replication-deficient adenovirus, have been...
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Novel viruses belonging to the family Circoviridae identified in wild American wigeon samples
Members of the family Circoviridae are known to infect several avian species, with the ability to cause severe disease outcomes in some species....
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Construction of and evaluation of the immune response to two recombinant pseudorabies viruses expressing the B119L and EP364R proteins of African swine fever virus
African swine fever (ASF) is an infectious disease caused by ASF virus (ASFV), which is characterized by high infectivity, rapid onset of disease,...
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Viruses and the Evolution of Viral Vectors
Since the first documented, widespread use of vaccines in the eighteenth century, vaccines have become a common health preventative for humans and...
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Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses
Influenza viruses cause a significant number of infections and deaths annually. In addition to seasonal infections, the risk of an influenza virus...
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Vaccines for Emerging Viruses—A Comprehensive Update
Over the past decade several notable viruses have suddenly emerged from obscurity to become serious public health problems and global threats,...