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Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells
Although functional interplay between intestinal microbiota and distant sites beyond the gut has been identified, the influence of microbiota-derived...
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Leptin promoter methylation in female patients with painful multisomatoform disorder and chronic widespread pain
BackgroundDifferent functional somatic syndromes (FSS), fibromyalgia (FMS) and other unexplained painful conditions share many common clinical traits...
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Intragastric safflower yellow and its main component HSYA improve leptin sensitivity before body weight change in diet-induced obese mice
Our previous studies found that safflower yellow (SY) and its main component hydroxysafflor yellow A (HSYA) could alleviate obesity and improve...
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The thrombin receptor PAR4 supports visceral adipose tissue inflammation
Thrombin inhibition suppresses adiposity, WAT inflammation and metabolic dysfunction in mice. Protease-activated receptor (PAR)1 does not account for...
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Elucidation of the effects of 2,5-hexandione as a metabolite of n-hexane on cognitive impairment in leptin-knockout mice (C57BL/6-Lepem1Shwl/Korl)
Exposure to n-hexane and its metabolite 2,5-hexandione (HD) is a well-known cause of neurotoxicity, particularly in the peripheral nervous system. To...
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Transient Receptor Potential Canonical (TRPC) as a Therapeutic Drug Target
Canonical or classical transient receptor potential (TRPC) proteins are nonselective cationic channels and a subset of TRP superfamily which are...
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Leptin Receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7
BackgroundLeptin Receptor (LEPR) has been suggested to have several roles in cancer metastasis. However, the role of LEPR and its underlying...
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Leptin receptor gene polymorphisms c.668A>G and c.1968G>C in Sudanese women with preeclampsia: a case-control study
BackgroundLeptin receptor gene ( LEPR ) variants may affect the leptin levels and act as a risk factor for preeclampsia. Two LEPR gene missense...
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Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior
Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C...
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Genetic Association of LEP Gene Polymorphisms with Obesity in Moroccan Individuals: Case–Control Study and Updated Meta-analysis
Obesity is a global epidemic disease representing the fifth leading cause of death in the world. It was shown that it is caused by the interaction...
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Receptor-Assisted Nanotherapeutics for Overcoming the Blood–Brain Barrier
Blood–brain barrier (BBB) is a distinguishing checkpoint that segregates peripheral organs from neural compartment. It protects the central nervous...
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Changes of the Concentration of Short-Chain Fatty Acids in the Intestines of Mice with Different Types of Obesity
We studied the production of short-chain fatty acids (SCFA) by the intestinal microbiota in mice with obesity caused by a diet and a genetic defect...
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The brain neuropeptides and STAT3 mediate the inhibitory effect of 17-β Estradiol on central leptin resistance in young but not aged female high-fat diet mice
Aging and menopause effect on body composition and energy balance. Estrogen (E2) plays an important role in body’s metabolism. The aim of the present...
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Novel Gene Therapy Approaches for Targeting Neurodegenerative Disorders: Focusing on Delivering Neurotrophic Genes
Neurodegenerative illnesses (NDDs) like Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, spinal muscular atrophy, and Huntington’s disease...
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Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats
Obesity has been linked with the impairment of spatial memory and synaptic plasticity but the molecular mechanisms remained unidentified. Since...
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Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines
Adiponectin (Acrp30) and leptin, adipokines produced and secreted mainly by the adipose tissue, are involved in human carcinogenesis. Thyroid...
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HDL and Scavenger Receptor Class B Type I (SRBI)
The scavenger receptor class B type I (SR-BI) is a versatile HDL receptor protein. It is highly expressed in liver and steroidogenic tissues. SR-BI...
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Current State of In Situ Gene Expression Studies in Animal Tissues
AbstractMorphological studies of farm animals are most often conducted using simple preparation and staining techniques. The study of the processes...
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Estrogen Receptor Alpha and ESR1 Mutations in Breast Cancer
The estrogen receptor alphaEstrogen receptor alpha (ERα) is a nuclear transcriptionTranscription factor that is expressed in more than 70% of all...