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High-Throughput Multiplex Immunohistochemistry of Glioma Organoids
The invasive capacity and progression of glioblastoma cells and neoplastic cells in other are dependent on interactions with the surrounding tumor...
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Functionally-instructed modifiers of response to ATR inhibition in experimental glioma
BackgroundThe DNA damage response (DDR) is a physiological network preventing malignant transformation, e.g. by halting cell cycle progression upon...
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Let-7b-5p promotes triptolide-induced growth-inhibiting effects in glioma by targeting IGF1R
Glioma is one of the most common malignancies of the central nervous system. The therapeutic effect has not been satisfactory despite advances in...
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From glioma gloom to immune bloom: unveiling novel immunotherapeutic paradigms-a review
In tumor therapeutics, the transition from conventional cytotoxic drugs to targeted molecular therapies, such as those targeting receptor tyrosine...
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Reactive Oxygen Species in Glioma
Glioma represents the lethal neoplasm of the brain with dismal progression in its most aggressive form, that is, glioblastoma. Hypoxia is well...
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WZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis
BackgroundGlioma is considered the most common primary malignant tumor of the central nervous system. Although traditional treatments have not...
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Reactive Oxygen Species in Glioma
Glioma represents the lethal neoplasm of the brain with dismal progression in its most aggressive form, that is, glioblastoma. Hypoxia is well...
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Glioma hexokinase 3 positively correlates with malignancy and macrophage infiltration
BackgroundGlioma is the main subtype of primary central nervous system (CNS) tumor with high malignancy and poor prognosis under current therapeutic...
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Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model
In malignant glioma, cytotoxic drugs are often inhibited from accessing the tumor site due to the blood-tumor barrier (BTB). Ibrutinib, FDA-approved...
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Oncohistones and disrupted development in pediatric-type diffuse high-grade glioma
Recurrent, clonal somatic mutations in histone H3 are molecular hallmarks that distinguish the genetic mechanisms underlying pediatric and adult...
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Association of NID2 SNPs with Glioma Risk and Prognosis in the Chinese Population
Glioma is the most common primary intracranial tumor with high mortality and poor prognosis. The purpose of this study was to investigate how...
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Multilevel chitosan–gelatin particles loaded with P4HA1 siRNA suppress glioma development
It has been reported that prolyl 4-hydroxylase subunit alpha 1 (P4HA1) promoted tumor growth and metastasis of glioma; thus, targeting P4HA1 may be a...
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Expression of STAT3 and hypoxia markers in long-term surviving malignant glioma patients
BackgroundGlioblastoma is a malignant and aggressive type of central nevous system malignancy characterized by many distinct biological features...
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EIF4A3-Induced Circ_0059914 Promoted Angiogenesis and EMT of Glioma via the miR-1249/VEGFA Pathway
Gliomas are common brain tumors. Despite extensive research, the 5-year survival rate of glioma remains low. Many studies have reported that circular...
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Brain injury drives optic glioma formation through neuron-glia signaling
Tissue injury and tumorigenesis share many cellular and molecular features, including immune cell (T cells, monocytes) infiltration and inflammatory...
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Inhibition of hyaluronic acid degradation pathway suppresses glioma progression by inducing apoptosis and cell cycle arrest
BackgroundAbnormal hyaluronic acid (HA) metabolism is a major factor in tumor progression, and the metabolic regulation of HA mainly includes HA...
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Targeting EZH2 regulates the biological characteristics of glioma stem cells via the Notch1 pathway
Glioma is the most common malignant brain tumor, and its behavior is closely related to the presence of glioma stem cells (GSCs). We found that the...
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Comprehensive analysis of microglia gene and subpathway signatures for glioma prognosis and drug screening: linking microglia to glioma
Glioma is the most common malignant tumors in the brain. Previous studies have revealed that, as the innate immune cells in nervous system, microglia...
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Copper Homeostasis Based on Cuproptosis-Related Signature Optimizes Molecular Subty** and Treatment of Glioma
Copper is essential in living organisms and crucial to various physiological processes. Normal physiological conditions are in a state of copper...
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Integrated profiling identifies CACNG3 as a prognostic biomarker for patients with glioma
Gliomas are the most common malignant primary brain tumors in adults with poor prognoses. The purpose of this study is to explore CACNG3 as a...
