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Agricultural Bioinformatics
Agricultural bioinformatics can play a very important role in improving crop productivity. The important areas of agricultural bioinformatics are...
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Medical Importance of ESKAPE Pathogens
Being the ‘escapers’ from the action of antibiotics, the ESKAPE pathogens—Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae,...
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Transcriptome Analysis of Different Sections of Rhizome in Polygonatum sibiricum Red. and Mining Putative Genes Participate in Polysaccharide Biosynthesis
As a traditional Chinese herb, the rhizomes of Polygonatum sibiricum Red. are rich in various compounds which have plenty of pharmacological...
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SCAPP: an algorithm for improved plasmid assembly in metagenomes
BackgroundMetagenomic sequencing has led to the identification and assembly of many new bacterial genome sequences. These bacteria often contain...
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The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates
BackgroundUp to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present...
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Computational Approaches for the Inhibition of ESKAPE Pathogens
According to the WHO priority pathogens list, the six nosocomial pathogens that exhibit resistance to several antibiotics are named as ESKAPE,...
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Exploring Toxin Evolution: Venom Protein Transcript Sequencing and Transcriptome-Guided High-Throughput Proteomics
Studying animal toxin evolution requires sequences of these proteins and peptides, and transcript sequences allow for the construction of cladograms...
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Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials
Predicting what will happen in the future in terms of potential reward is essential in daily life. The aim of the current study was to investigate...
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PCycDB: a comprehensive and accurate database for fast analysis of phosphorus cycling genes
BackgroundPhosphorus (P) is one of the most essential macronutrients on the planet, and microorganisms (including bacteria and archaea) play a key...
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Guidelines for Setting Up a mRNA Sequencing Experiment and Best Practices for Bioinformatic Data Analysis
RNA-sequencing, commonly referred to as RNA-seq, is the most recently developed method for the analysis of transcriptomes. It uses high-throughput...
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Measuring and interpreting transposable element expression
Transposable elements (TEs) are insertional mutagens that contribute greatly to the plasticity of eukaryotic genomes, influencing the evolution and...
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Fast and accurate genomic analyses using genome graphs
The human reference genome serves as the foundation for genomics by providing a scaffold for alignment of sequencing reads, but currently only...
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Somatic and Germline Variant Calling from Next-Generation Sequencing Data
Re-sequencing of the human genome by next-generation sequencing (NGS) has been widely applied to discover pathogenic genetic variants and/or...
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Assessment of the In Vivo Response to Nanobody-Targeted PDT Through Intravital Microscopy
Methods that allow real-time, longitudinal, intravital detection of the fluorescence distribution and the cellular and vascular responses within...
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Virome in adult Aedes albopictus captured during different seasons in Guangzhou City, China
BackgroundThe mosquito Aedes albopictus is an important vector for many pathogens. Understanding the virome in Ae. albopictus is critical for...
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RNA-Sequencing of Snake Venom Glands
Next-generation sequencing (NGS), particularly RNA-sequencing (RNA-Seq) technique, allows detection and quantification of different RNA transcripts...
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Geno-informatics for Prediction of Virulence and Drug Resistance in Bacterial Pathogens
In recent years, there has been a rapid surge in the number of resistant strains of bacterial pathogens, mainly due to misuse of antibiotics in our...
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Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3
Impaired chronic viral and tumor clearance has been attributed to CD8 + T cell exhaustion, a differentiation state in which T cells have reduced and...
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Informatics for PacBio Long Reads
In this article, we review the development of a wide variety of bioinformatics software implementing state-of-the-art algorithms since the...
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The Architecture of a Precision Oncology Platform
Precision oncology is a novel research field and approach to cancer care which leverages high-throughput sequencing technologies and bioinformatics...