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Lectures 13–16: Nervous System
The Nervous System consists of the Central nervous system (the brain and spinal cord) and the Peripheral nervous system (neural tissue outside of the...
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Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
Multiple sclerosis (MS) is an immune-mediated central nervous system (CNS) disease characterized by demyelination resulting from oligodendrocyte loss...
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Immunological Markers for Central Nervous System Glia
Glial cells in the central nervous system (CNS) are composed of oligodendrocytes, astrocytes and microglia. They contribute more than half of the...
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High Frequency of Autoantibodies in COVID-19 Patients with Central Nervous System Complications: a Multicenter Observational Study
We present a panel of central nervous system (CNS) complications associated with coronavirus disease 2019 (COVID-19) and their clinical...
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Tripartite Motif Protein Family in Central Nervous System Diseases
Tripartite motif (TRIM) protein superfamily is a group of E3 ubiquitin ligases characterized by the conserved RING domain, the B-box domain, and the...
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Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target
The extracellular matrix is a richly bioactive composition of substrates that provides biophysical stability, facilitates intercellular signaling,...
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Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies
CELSR3 codes for a planar cell polarity protein. We describe twelve affected individuals from eleven independent families with bi-allelic variants in CELSR3...
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Role of O-GlcNAcylation in Central Nervous System Development and Injuries: A Systematic Review
The development of central nervous system (CNS) can form perceptual, memory, and cognitive functions, while injuries to CNS often lead to severe...
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Critical Roles of Protein Arginine Methylation in the Central Nervous System
A remarkable post-transitional modification of both histones and non-histone proteins is arginine methylation. Methylation of arginine residues is...
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Central Nervous System Tuberculosis: Pathogenesis, Diagnosis, and Management
Tuberculosis (TB) affects theSystemcentral nervous central nervous systemCNSCentral nervous system (CNS) in several distinct but interrelated ways....
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miR-122-5p Promotes Peripheral and Central Nervous System Inflammation in a Mouse Model of Intracerebral Hemorrhage via Disruption of the MLLT1/PI3K/AKT Signaling
Intracerebral hemorrhage (ICH) is a recognized central nervous system inflammation complication. Several microRNAs (miRNAs or miRs) have been...
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Epigenetic Regulation of Ferroptosis in Central Nervous System Diseases
Ferroptosis, a newly identified form of cell death, is characterized by iron overload and accumulation of lipid reactive oxygen species. Inactivation...
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Strategies for enhanced bioavailability of oxime reactivators in the central nervous system
Oxime reactivators of acetylcholinesterase are commonly used to treat highly toxic organophosphate poisoning. They are effective nucleophiles that...
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PEG300 Protects Mitochondrial Function By Upregulating PGC-1α to Delay Central Nervous System Oxygen Toxicity in Mice
Central nervous system oxygen toxicity (CNS-OT) is a complication of hyperbaric oxygen (HBO) treatment, with limited prevention and treatment options...
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Ergothioneine and central nervous system diseases
Ergothioneine (ERGO) is a thiol contained in the food that exhibits an excellent antioxidant effect similar to that of glutathione. Although mammals...
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Central nervous system-derived extracellular vesicles: the next generation of neural circulating biomarkers?
The central nervous system (CNS) is integrated by glial and neuronal cells, and both release extracellular vesicles (EVs) that participate in CNS...
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Effects of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes in Central Nervous System Diseases
Central nervous system (CNS) diseases are one of the diseases that threaten human health. The delivery of drugs targeting the CNS has always been a...
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Roles of neuroligins in central nervous system development: focus on glial neuroligins and neuron neuroligins
Neuroligins are postsynaptic cell adhesion molecules that are relevant to many neurodevelopmental disorders. They are differentially enriched at the...
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Nanopore targeted sequencing-based diagnosis of central nervous system infections in HIV-infected patients
BackgroundEarly and accurate etiological diagnosis is very important for improving the prognosis of central nervous system (CNS) infections in human...
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Localized microglia dysregulation impairs central nervous system myelination in development
Myelination of neuronal axons is a critical aspect of central nervous system development and function. However, the fundamental cellular and...
