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Fibroblast Activation Protein (FAP): A Key Modulator of the Cancer Microenvironment
Fibroblast activation protein-α (FAP) is a type II transmembrane serine protease with extensive endonuclease activity that is almost undetectable in...
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Activation and Functions of Plasmacytoid Dendritic Cells
The major functional identity of plasmacytoid dendritic cells (pDCs), despite their ontogenic affiliation to the dendritic cell (DC) lineage of...
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ZINC40099027 promotes monolayer circular defect closure by a novel pathway involving cytosolic activation of focal adhesion kinase and downstream paxillin and ERK1/2
ZINC40099027 (ZN27) is a specific focal adhesion kinase (FAK) activator that promotes murine mucosal wound closure after ischemic or NSAID-induced...
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Effect of muscle activation on dynamic responses of neck of pilot during emergency ejection: a finite element study
To determine the effect of muscle activation on the dynamic responses of the neck of a pilot during simulated emergency ejections. A complete finite...
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PRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6
BackgroundMacrophages play significant roles in innate immune responses and are heterogeneous cells that can be polarized into M1 or M2 phenotypes....
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Mechanisms of Oncogenesis
Carcinogenesis can be due to replication errors, faulty repair of damaged DNA, and exposure to DNA-damaging agents. The two major carcinogenesis...
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RACK1 interaction with c-Src is essential for osteoclast function
The scaffolding protein receptor for activated C-kinase 1 (RACK1) mediates receptor activator of nuclear factor κΒ ligand (RANKL)-dependent...
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Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation
BackgroundSynthetic amorphous silica nanoparticles (SAS-NPs) are widely employed in pharmaceutics, cosmetics, food and concretes. Workers and the...
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High glucose enhances the activation of NLRP3 inflammasome by ambient fine particulate matter in alveolar macrophages
BackgroundEpidemiological studies have demonstrated that individuals with preexisting conditions, including diabetes mellitus (DM), are more...
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Proteomic analysis of lysine 2-hydroxyisobutyryl in SLE reveals protein modification alteration in complement and coagulation cascades and platelet activation Pathways
BackgroundPost-translational modifications (PTMs) are considered to be an important factor in the pathogenesis of Systemic lupus erythematosus (SLE)....
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RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling
BackgroundMetastasis is one of the leading cause contributes to treatment failure and poor prognosis of hepatocellular carcinoma (HCC) patients. The...
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The constitutive activation of STAT3 gene and its mutations are at the crossroad between LGL leukemia and autoimmune disorders
Type T Large Granular Lymphocyte Leukemia (T-LGLL) is a chronic disorder characterized by the abnormal proliferation of clonal cytotoxic T cells. The...
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Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment
BackgroundThe tumor immune microenvironment (TIME) generated by cancer-infiltrating immune cells has a crucial role in promoting or suppressing...
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A synthetic bioactive peptide of the C-terminal fragment of adhesion protein Fibulin7 attenuates the inflammatory functions of innate immune cells in LPS-induced systemic inflammation
ObjectiveSystemic inflammation is associated with improper localization of hyperactive neutrophils and monocytes in visceral organs. Previously, a...
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Pak1 pathway hyper-activation mediates resistance to endocrine therapy and CDK4/6 inhibitors in ER+ breast cancer
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) have been approved in combination with endocrine therapy (ET) to treat estrogen...
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Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension
Toll-like receptor 4 (TLR4) and cellular Src (c-Src) are closely associated with inflammatory cytokines and oxidative stress in hypertension, so we...
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Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood–Brain Barrier in vitro
BackgroundThe aim of this study was to further explore the role of caveolin-1 (Cav-1) related Akt/mTOR signaling pathway in blood brain barrier (BBB)...
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Mechanisms of Oncogenesis
Carcinogenesis can be due to replication errors, faulty repair of damaged DNA, and exposure to DNA-damaging agents. The two major carcinogenesis...
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Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells
Inhibitory receptors (IRs), such as the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), are cell surface molecules expressed on...
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CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation
BackgroundOsteosarcoma (OS) is the most common malignant bone tumor with a high incidence in children and adolescents. Frequent tumor metastasis and...
