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Hexahydrocurcumin attenuated demyelination and improved cognitive impairment in chronic cerebral hypoperfusion rats
Age-related white matter lesions (WML) frequently present vascular problems by decreasing cerebral blood supply, resulting in the condition known as...
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Immune cell infiltration and inflammatory landscape in primary brain tumours
BackgroundPrimary malignant brain tumours are more than one-third of all brain tumours and despite the molecular investigation to identify cancer...
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Determination of Autoantibodies to Transglutaminase by Electrochemiluminescence (ECL) Assay
Appearance of autoantibodies to tissue transglutaminase (TGA) is the most reliable biomarker to identify celiac disease autoimmunity. A...
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Pediatric Celiac Disease and Selective IgA Deficiency: Unexpected Sequence of Events
PurposeSelective IgA deficiency (IgAD) is the most common primary immunodeficiency, frequently leading to only minor clinical complaints. IgAD may be...
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Gluten Ataxia
Gluten ataxia (GA) is defined as sporadic ataxia with positive serological markers for gluten sensitivity and in the absence of an alternative...
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Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression
BackgroundTissue transglutaminase (tTG)-regulating IL-13 plays an important role in the pathogenesis of liver fibrosis resulting from Schistosoma...
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Efficient Production of Homogeneous Lysine-Based Antibody Conjugates Using Microbial Transglutaminase
Random conjugation of chemical linkers to endogenous lysines or cysteines within an antibody yields a heterogeneous mixture of conjugates with...
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Ethacrynic acid is an inhibitor of human factor XIIIa
BackgroundEthacrynic acid (EA) is a loop diuretic that is approved orally and parenterally to manage edema-associated diseases. Nevertheless, it was...
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Detection of human platelets antigen polymorphism (HPA-1 and HPA-3) and human factor XIII mutation in Sudanese women with recurrent pregnancy loss
BackgroundRecurrent pregnancy Loss (RPL) is common problem affecting many couples. A certain genetic variants link to increase the danger of this...
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TG2 as a novel breast cancer prognostic marker promotes cell proliferation and glycolysis by activating the MEK/ERK/LDH pathway
BackgroundBreast cancer (BC) is the most common malignant tumor among women worldwide. Tissue transglutaminase 2 ( TG2 ) has been reported as a major...
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HLA and Disease Association
An interesting application of HLA in medicine was the description of the increased incidence of some HLA class-I and class-II alleles in patients...
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Decoy receptor 3 is involved in epidermal keratinocyte commitment to terminal differentiation via EGFR and PKC activation
Decoy receptor 3 (DcR3) is a soluble receptor for Fas ligand, LIGHT and TL1A, but it also exerts effector functions. Previously, we found that DcR3...
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Transglutaminases are oncogenic biomarkers in human cancers and therapeutic targeting of TGM2 blocks chemoresistance and macrophage infiltration in pancreatic cancer
PurposeTransglutaminases (TGs) are multifunctional enzymes exhibiting transglutaminase crosslinking, as well as atypical GTPase/ATPase and kinase...
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Cerebrospinal Fluid Biomarkers in Huntington’s Disease
Huntington’s disease (HD) is a devastating neurodegenerative disorder caused by a CAG repeat expansion mutation in the HTT gene that leads to...
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Cerebellar presence of immune cells in patients with neuro-coeliac disease
Although various neurodegenerative disorders have been associated with coeliac disease (CD), the underlying neuropathological link between these...
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The molecular mechanisms of remodeling in asthma, COPD and IPF with a special emphasis on the complex role of Wnt5A
IntroductionChronic inflammatory lung diseases are a common cause of suffering and death. Chronic obstructive pulmonary disease (COPD) is the reason...
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Beispiele für entzündliche Immunpathologien
Als Beispiele für entzündliche Immunopathien werden folgende besprochen: Sepsis, Asthma, Diabetes Typ 1, Multiple Sklerose, Rheumatoide Arthritis,...
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Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease
Alzheimer’s disease (AD) poses an ever-increasing public health concern as the population ages, affecting more than 6 million Americans. AD patients...
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Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy
Dynamic interactions between organelles are responsible for a variety of intercellular functions, and the endoplasmic reticulum (ER)–mitochondrial...
