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Histone Modifying Potential of Dietary Phytochemicals: Implications in Treating Breast Cancer
Purpose of ReviewBreast cancer is a metastatic carcinoma that is recognized as a leading cause of death in women worldwide and is still an unanswered...
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The role of kinesin family members in hepatobiliary carcinomas: from bench to bedside
As a major component of the digestive system malignancies, tumors originating from the hepatic and biliary ducts seriously endanger public health....
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Potential mechanisms of cancer prevention and treatment by sulforaphane, a natural small molecule compound of plant-derived
Despite recent advances in tumor diagnosis and treatment technologies, the number of cancer cases and deaths worldwide continues to increase yearly,...
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Mechanisms of radiotherapy resistance and radiosensitization strategies for esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-related mortality worldwide, with more than half of them occurred...
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Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Metastasis remains the principal trigger for relapse and mortality across diverse cancer types. Circulating tumor cells (CTCs), which originate from...
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Sirtuins as molecular targets, mediators, and protective agents in metal-induced toxicity
Metal dyshomeostasis, and especially overexposure, is known to cause adverse health effects due to modulation of a variety of metabolic pathways. An...
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ROS/Redox Regulation with Dietary Phytochemicals and Role in Anticancer Activity
This chapter entitled “ROS/Redox Regulation with Dietary Phytochemicals and Role in Anticancer Activity” initially introduces the classification of...
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Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer
Colorectal neoplasms are one of the deadliest diseases among all cancers worldwide. Thymoquinone (TQ) is a natural compound of Nigella sativa that...
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Role of non-canonical post-translational modifications in gastrointestinal tumors
Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that...
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Short-chain fatty acids in cancer pathogenesis
Cancer is a multi-step process that can be viewed as a cellular and immunological shift away from homeostasis in response to selected infectious...
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Evaluating the Role of RUNX2 in Cancer and Its Potential as a Therapeutic Target
RUNX2, the transcription factor of the RUNX family, plays a critical role in homeostasis and a variety of pathological conditions, including cancer....
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Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery
Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved in almost all cancer hallmark features including...
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Synergistic effects of flavonoids and paclitaxel in cancer treatment: a systematic review
Paclitaxel is a natural anticancer compound with minimal toxicity, the capacity to stabilize microtubules, and high efficiency that has remained the...
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Energy metabolism as the hub of advanced non-small cell lung cancer management: a comprehensive view in the framework of predictive, preventive, and personalized medicine
Energy metabolism is a hub of governing all processes at cellular and organismal levels such as, on one hand, reparable vs. irreparable cell damage,...
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Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging...
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Promoting reactive oxygen species accumulation to overcome tyrosine kinase inhibitor resistance in cancer
BackgroundIn tumor treatment, protein tyrosine kinase inhibitors (TKIs) have been extensively utilized. However, the efficacy of TKI is significantly...
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STAT3 pathway as a molecular target for resveratrol in breast cancer treatment
Signal transducer and activator of transcription 3 (STAT3) induces breast cancer malignancy. Recent clinical and preclinical studies have...
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Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma
BackgroundExtranodal natural killer/T-cell lymphoma (NKTL) is an aggressive type of non-Hodgkin lymphoma with dismal outcome. A better understanding...
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Targeting histone deacetylases in head and neck squamous cell carcinoma: molecular mechanisms and therapeutic targets
The onerous health and economic burden associated with head and neck squamous cell carcinoma (HNSCC) is a global predicament. Despite the advent of...
