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Optogenetic Modulation of the Visceromotor Response to Reveal Visceral Pain Mechanisms
Visceral pain is a debilitating condition that is common yet lacks effective treatments. In the case of gastrointestinal disorders (e.g.,...
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Synaptic Tagging and Metaplasticity as Mediators of Neuronal Consciousness
Forming memories for highly arousing, novel, or salient events engages synaptic mechanisms that allow the association of temporally remote events and...
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Learned Helplessness in Rodents
Learned helplessness (LH) is a well-known phenomenon described in animals upon their exposure to uncontrollable and unpredictable aversive stimuli,...
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Effects of Intrathecal Administration of Prostaglandin-D2 on Stress-Induced Analgesia: Involvements of DP2 Receptors
AbstractProstaglandin D 2 is the most abundant prostaglandin in the mammalian brain. Exposure to stressful stimuli is often accompanied by reduced...
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One Phenomenon with Many Interpretations: Asymmetry of the Frontal EEG α Rhythm in Healthy People. Part II
This article reviews neuroscience studies of frontal α asymmetry in healthy people. Right-sided α asymmetry is associated with sensitivity to...
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Multiplexed Immunoassay Using Quantum Dots to Monitor Proteins Secreted from Single Cells at Near-Single Molecule Resolution
Single-cell secretion studies find important applications in molecular diagnostics, therapeutic target identification, and basic biology research....
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The use of eye-tracking technology as a tool to evaluate social cognition in people with an intellectual disability: a systematic review and meta-analysis
BackgroundRelatively little is known about social cognition in people with intellectual disability (ID), and how this may support understanding of...
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Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation
Sleep deprivation has been shown to increase pain intensity and decrease pain thresholds in healthy subjects. In chronic pain patients, sleep...
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Inferring Brain State Dynamics Underlying Naturalistic Stimuli Evoked Emotion Changes With dHA-HMM
The brain functional mechanisms underlying emotional changes have been primarily studied based on the traditional task design with discrete and...
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Differences in the pupillary responses to evening light between children and adolescents
BackgroundIn the mammalian retina, intrinsically-photosensitive retinal ganglion cells (ipRGC) detect light and integrate signals from rods and cones...
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The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour
RationaleAdenosine A 2A receptors (A 2A R) in the dorsal striatum have been implicated in goal-directed behaviour. While activation of these receptors...
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Screening Methods for the Evaluation of General Anaesthetics
General anaesthetics are drugs which induce a reversible state of loss of consciousness with reduced motility, attenuated response to painful stimuli...
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5-HT 2A and 5-HT 2C receptor antagonism differentially modulate reinforcement learning and cognitive flexibility: behavioural and computational evidence
RationaleCognitive flexibility, the ability to adapt behaviour in response to a changing environment, is disrupted in several neuropsychiatric...
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Adolescent THC exposure: effects on pain-related, exploratory, and consummatory behaviors in adult male vs. female rats
RationaleAdolescent cannabinoid exposure has been shown to alter cognitive, reward-related, and motor behaviors as well as mesocorticolimbic dopamine...
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Bayesian prediction of psychophysical detection responses from spike activity in the rat sensorimotor cortex
Decoding of sensorimotor information is essential for brain-computer interfaces (BCIs) as well as in normal functioning organisms. In this study,...
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C57BL/6J offspring mice reared by a single-mother exhibit, compared to mice reared in a biparental parenting structure, distinct neural activation patterns and heightened ethanol-induced anxiolysis
RationaleParenting experiences with caregivers play a key role in neurodevelopment. We recently reported that adolescents reared by a single-mother...
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Anti-inflammatory potential of liraglutide, a glucagon-like peptide-1 receptor agonist, in rats with peripheral acute inflammation
The present study aimed to explore the possible anti-inflammatory actions of liraglutide (LRG), a glucagon-like peptide-1 (GLP-1) receptor agonist,...
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Abnormal trial-to-trial variability in P300 time-varying directed eeg network of schizophrenia
Cognitive disturbance in identifying, processing, and responding to salient or novel stimuli are typical attributes of schizophrenia (SCH), and P300...
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Optic flow selectivity in the macaque parieto-occipital sulcus
In humans, several neuroimaging studies have demonstrated that passive viewing of optic flow stimuli activates higher-level motion areas, like V6 and...
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Automatic detection of peripheral stimuli in shooters and handball players: an event-related potential study
This study examined the practice-related sensitivity of automatic change detection. The visual mismatch negativity (vMMN) component of event-related...
