Search
Search Results
-
Nicotine preference and affective behavior of Cd81 knockout mice
RationaleCd81 -/- (knockout) mice have previously been reported to have reduced cocaine preference and increased striatal dopamine content and...
-
Distinct roles of the meningeal layers in CNS autoimmunity
The meninges, comprising the leptomeninges (pia and arachnoid layers) and the pachymeninx (dura layer), participate in central nervous system (CNS)...
-
Preparatory activity and the expansive null-space
The study of the cortical control of movement experienced a conceptual shift over recent decades, as the basic currency of understanding shifted from...
-
Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice
Itch—a major symptom of many chronic skin diseases—can exacerbate inflammation by provoking scratching and subsequent skin damage. Here, we show that...
-
A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis
BackgroundAtopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high...
-
Effects of a Nociceptin Receptor Antagonist on Experimentally Induced Scratching Behavior in Mice
Itch and pain are two distressing sensations sharing a lot in common. In addition to the periphery, the central nervous system is proposed as a...
-
Drug Self-Administration as a Model to Study the Reward System
Laboratory animals voluntarily self-administer almost all drugs of abuse humans do. Laboratory animals also develop patterns of drug-taking and...
-
Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model
BackgroundTopical administration of PR022, 0.05% hypochlorous acid (HOCl) in gel has been demonstrated to be beneficial in a chronic murine atopic...
-
A pivotal role for the activation of TRPV3 channel in itch sensations induced by the natural skin sensitizer carvacrol
Itching is an intricate, common symptom of dermatologic and systemic diseases, and both TRPV3 and TRPA1 channels have been suggested to function as...
-
Ring Chromosomes from Patients’ Perspective
Ring chromosomes (RCs) are normally reported in the scientific literature exclusively from the (cyto) genetic and/or clinical point of view. There is...
-
Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice
The anti-inflammatory effects of histamine H4 receptor (H4R) antagonists opened new therapeutic options for the treatment of inflammatory/allergic...
-
Dissociable effects of the kappa opioid receptor agonist nalfurafine on pain/itch-stimulated and pain/itch-depressed behaviors in male rats
RationaleNalfurafine is a G protein signaling-biased kappa opioid receptor (KOR) agonist approved in Japan for second-line treatment of uremic...
-
Fungal Diseases and Their Treatment: A Holistic Approach
Fungal infections are one of the most common infections in humans and other animals. Fungal diseases are more common in tropical and subtropical...
-
Rates of hematophagous ectoparasite consumption during grooming by an endemic Madagascar fruit bat
BackgroundFew details are available on the consumption of ectoparasites, specifically bat flies (Diptera: Nycteribiidae and Streblidae), by their...
-
Introduction to Neurophysiology
Neurophysiology is a critical and exciting topic to study and understand in great detail for those working in any field associated with...
-
The fading trail of the sleepy wraith
Encephalitis lethargica was an enigma throughout its one and only epidemic. All those who have concerned themselves with this disease have been...
-
Multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events
Fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousands patients worldwide....
-
Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis
Atopic dermatitis is a common allergic skin disease characterized by eczematous lesions and pruritus. Experimental animal models are essential tools...
-
Hand, Limb, and Other Motor Preferences
Historically, many cognitive competencies have been considered human unique. An anthropomorphic mindset has thwarted a better understanding of...