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Chemotherapy-Induced Peripheral Neuropathy in Children Treated for Acute Lymphoblastic Leukemia: A Role for Oxidative Stress and Brain-Derived Neurotrophic Factor
AbstractThe toxicity of chemotherapy agents to the peripheral nervous system (PNS) often manifests itself as chemotherapy-induced peripheral...
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Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo
Bakuchiol (Bak) possesses a protective effect in acute lung injury (ALI). Nonetheless, the molecular processes that regulate the protective activity...
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Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats
Cisplatin, a chemotherapy drug containing platinum, is considered a neurotoxic agent. On the other hand, crocin, the primary component of saffron,...
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Betaine alleviates doxorubicin-related cardiotoxicity via suppressing oxidative stress and inflammation via the NLRP3/SIRT1 pathway
Cardiotoxicity is one of the side effects of the anti-cancer drug doxorubicin (DOX) that limits its clinical application. Betaine (BT) is a natural...
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Rosavin extends lifespan via the insulin/IGF-1 signaling pathway in Caenorhabditis elegans
Rosavin, a phenylpropanoid glycoside, is the specific index component and one of the main active components of Rhodiola rosea . Currently, there are...
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Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats
Mercury chloride (ME) is a chemical pollutant commonly found in the environment, which can contribute to undesirable health consequence worldwide....
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Superoxide Dismutase Activity in Male and Female Patients of Different Age with Moderate COVID-19
The study involved 271 patients (132 men and 139 women) with moderate COVID-19. Superoxide dismutase (SOD) activity in erythrocytes was measured...
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The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory with Respect to the Oxidative Status of Rats
Sleep deprivation (SD) has deleterious effects on cognitive functions including learning and memory. However, some studies have shown that SD can...
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Tannic acid may ameliorate doxorubicin-induced changes in oxidative stress parameters in rat spleen
Doxorubicin (DOX) is a potent and broad-spectrum drug widely used in the treatment of cancer. However, the toxicity and side effects of DOX on...
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The power of trans-sodium crocetinate: exploring its renoprotective effects in a rat model of colistin-induced nephrotoxicity
Colistin, a multidrug-resistant gram-negative bacterial infection medication, has been associated with renal impairment and failure. Trans-sodium...
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Silver nanoparticles synthesized from Quercus brantii ameliorated ethanol-induced gastric ulcers in rats by decreasing oxidative stress and improving antioxidant systems
Gastric ulcers are caused by an imbalance between aggressive and defensive factors. The green synthesis of silver nanoparticles is becoming a new and...
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Tramadol induces apoptosis, inflammation, and oxidative stress in rat choroid plexus
BackgroundThe choroid plexus (CP) is the principal source of cerebrospinal fluid (CSF). It can produce and release a wide range of materials,...
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Doxycycline-Loaded Calcium Phosphate Nanoparticles with a Pectin Coat Can Ameliorate Lipopolysaccharide-Induced Neuroinflammation Via Enhancing AMPK
Neuroinflammation occurs in response to different injurious triggers to limit their hazardous effects. However, failure to stop this process can end...
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Identification of Cyto- and Genotoxic Effects of Lunularic Acid in Allium cepa L. Root Tip Meristem Cells
AbstractIn this study, dose-dependent effects of lunularic acid (LA) on some physiological, cytogenetic, biochemical and anatomical parameters were...
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Chemical hypermethioninemia in young mice: oxidative damage and reduction of antioxidant enzyme activity in brain, kidney, and liver
High levels of methionine (Met) and its metabolites, such as methionine sulfoxide (MetO), found in hypermethioninemia, can be detrimental to the...
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Distinct concentration-dependent oxidative stress profiles by cadmium in a rat kidney proximal tubule cell line
Levels and chemical species of reactive oxygen/nitrogen species (ROS/RNS) determine oxidative eustress and distress. Abundance of uptake pathways and...
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Vincamine alleviates intrahepatic cholestasis in rats through modulation of NF-kB/PDGF/klf6/PPARγ and PI3K/Akt pathways
The defect in the hepatobiliary transport system results in an impairment of bile flow, leading to accumulation of toxic compounds with subsequent...
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Therapeutic Effects of Citral Nanoliposome on Parkinson’s Treatment in a Rat Model: Modulation via Neurochemical, Inflammatory and Antioxidant Pathways
AbstractParkinson’s disease is the most common neurodegenerative movement disorder, the pathogenesis of which is partly related with oxidant status...
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Levamisole Impairs Vascular Function by Blocking α-Adrenergic Receptors and Reducing NO Bioavailability in Rabbit Renal Artery
Levamisole is an anthelmintic drug restricted to veterinary use but is currently detected as the most widely used cocaine cutting agent in European...
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Hederagenin Upregulates PTPN1 Expression in Aβ-Stimulated Neuronal Cells, Exerting Anti-Oxidative Stress and Anti-Apoptotic Activities
Alzheimer’s disease (AD) is a prevalently neurodegenerative disease characterized by neuronal damage which is associated with amyloid-β (Aβ)...
