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CM-Path Molecular Diagnostics Forum—consensus statement on the development and implementation of molecular diagnostic tests in the United Kingdom
BackgroundPathology has evolved from a purely morphological description of cellular alterations in disease to our current ability to interrogate...
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KRAS is a molecular determinant of platinum responsiveness in glioblastoma
BackgroundKRAS is the undisputed champion of oncogenes, and despite its prominent role in oncogenesis as mutated gene, KRAS mutation appears...
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Benefits of applying molecular barcoding systems are not uniform across different genomic applications
BackgroundDespite the wide variety of Next Generation Sequencing (NGS)-based methods, it remains challenging to detect mutations present at very low...
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Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians
BackgroundType 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the...
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Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features
Neuronal heterogeneity has been established as a pillar of higher central nervous system function, but glial heterogeneity and its implications for...
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Diagnostics and Personalized Medicine
The drug discovery landscape is changing with the advent of personalized medicine and the companion diagnostics that are used to select patients who...
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A molecular toolbox for fast and convenient diagnosis of emerging and reemerging bacterial pathogens causing fever of intermediate duration
PurposeFever of intermediate duration (FID) is defined as a fever in the community without a specific origin or focus, with a duration between 7 and...
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Systematic in vitro analysis of therapy resistance in glioblastoma cell lines by integration of clonogenic survival data with multi-level molecular data
Despite intensive basic scientific, translational, and clinical efforts in the last decades, glioblastoma remains a devastating disease with a highly...
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Molecular alterations and clinical prognostic factors in resectable non-small cell lung cancer
BackgroundEGFR inhibitor and immunotherapy have been approved for adjuvant treatment in resectable non-small cell lung cancer (NSCLC). Limited...
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Molecular epidemiology and diagnostics of KRAS mutations in human cancer
RAS mutation is the most frequent oncogenic alteration in human cancers. KRAS is the most frequently mutated followed by NRAS. The emblematic KRAS...
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Molecular Progression of Breast Cancer and Personalized Medicine in Terms of Clinical Trials
Breast cancer (BC) is well-known for its diversified clinical behaviors despite the similar histopathological characteristics at diagnosis. Research...
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The Opportunities and Challenges of Molecular Tagging Next-Generation Sequencing in Liquid Biopsy
Liquid biopsy (LB) is a promising tool that is rapidly evolving as a standard of care in early and advanced stages of cancer settings....
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Overcoming Clinical Research Disparities by Advancing Inclusive Research
Achieving personalized healthcare for all people, including the most vulnerable Hispanic communities, may appear to be an insurmountable task or an...
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An integrated multi-omic approach demonstrates distinct molecular signatures between human obesity with and without metabolic complications: a case–control study
ObjectivesTo examine the hypothesis that obesity complicated by the metabolic syndrome, compared to uncomplicated obesity, has distinct molecular...
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Insulin receptor expression to predict resistance to axitinib and elucidation of the underlying molecular mechanism in metastatic renal cell carcinoma
BackgroundThe study aimed to examine the significance of insulin receptor (INSR) expression in predicting resistance to axitinib in clear cell renal...
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Molecular Diagnosis of Primary Cardiomyopathy in 231 Unrelated Pediatric Cases by Panel-Based Next-Generation Sequencing: A Major Focus on Five Carriers of Biallelic TNNI3 Pathogenic Variants
Background and ObjectivePediatric cardiomyopathies are clinically heterogeneous heart muscle disorders associated with significant morbidity and...
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Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer
To evaluate the clinical impact of molecular tumor profiling (MTP) with targeted sequencing panel tests, pediatric patients with extracranial solid...
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Automation Techniques in Mycobacteriology
In this era of globalisation and pandemics, automation in clinical laboratories is in huge demand as it enhances the workflow process. Laboratory...
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An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer
BackgroundEndometrial cancer (EC) is one of the most common gynecological malignancies globally, and the development of innovative, effective drugs...
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Diagnostic Accuracy of Two Molecular Tools for Diagnosis of Congenital Chagas Disease
Background and ObjectiveThe real prevalence of congenital Chagas disease is undefined because of difficulties in the detection of Trypanosoma cruzi ...
