Search
Search Results
-
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and despite considerable progress in treatment outcomes, relapses still...
-
Control Banding and the Global Rise of Qualitative Risk Assessment Strategies
Purpose of ReviewControl banding (CB) is a risk assessment strategy that has been applied globally to a variety of occupational hazards. This article...
-
Establishment of a potent weighted risk model for determining the progression of diabetic kidney disease
BackgroundDiabetic kidney disease (DKD) is a severe complication of diabetes. Currently, no effective measures are available to reduce the risk of...
-
A prognostic risk score for development and spread of chronic pain
Chronic pain is a complex condition influenced by a combination of biological, psychological and social factors. Using data from the UK Biobank ( n = 4...
-
Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification
Although the cohort-level accuracy of polygenic risk scores (PRSs)—estimates of genetic value at the individual level—has been widely assessed,...
-
Nine dietary habits and risk of colorectal cancer: a Mendelian randomization study
BackgroundEpidemiological studies have provided evidence that there is an association between diet and colorectal cancer. However, the causal...
-
-
Dental health and lung cancer risk in the Golestan Cohort Study
BackgroundPoor oral health has been linked to various systemic diseases, including multiple cancer types, but studies of its association with lung...
-
Supplement use and gastric cancer risk in the Southern Community Cohort Study
PurposeGastric cancer remains a racial health disparity in the US, but few studies have examined supplements as a potential protective factor. We...
-
The Burden of Proof studies: assessing the evidence of risk
Exposure to risks throughout life results in a wide variety of outcomes. Objectively judging the relative impact of these risks on personal and...
-
CT Angiography Radiomics Combining Traditional Risk Factors to Predict Brain Arteriovenous Malformation Rupture: a Machine Learning, Multicenter Study
This study aimed to develop a machine learning model for predicting brain arteriovenous malformation (bAVM) rupture using a combination of...
-
Interplay of Mendelian and polygenic risk factors in Arab breast cancer patients
BackgroundBreast cancer patients from the indigenous Arab population present much earlier than patients from Western countries and have traditionally...
-
Machine learning for ECG diagnosis and risk stratification of occlusion myocardial infarction
Patients with occlusion myocardial infarction (OMI) and no ST-elevation on presenting electrocardiogram (ECG) are increasing in numbers. These...
-
BridgePRS leverages shared genetic effects across ancestries to increase polygenic risk score portability
Here we present BridgePRS, a novel Bayesian polygenic risk score (PRS) method that leverages shared genetic effects across ancestries to increase PRS...
-
Machine learning algorithm to evaluate risk factors of diabetic foot ulcers and its severity
Early identification of the risk factors associated with development of diabetic foot ulcer (DFU) can be facilitated using machine learning...
-
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction
Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To...
-
Plant-based dietary patterns, genetic predisposition and risk of colorectal cancer: a prospective study from the UK Biobank
BackgroundPlant-based dietary patterns may affect colorectal cancer (CRC) related outcomes, while risks differ in the quality of plant foods. We...
-
Genetic risk factors have a substantial impact on healthy life years
The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of...
-
Microcalcifications, mammographic breast density, and risk of breast cancer: a cohort study
BackgroundBreast density and microcalcifications are strongly associated with the risk of breast cancer. However, few studies have evaluated the...
-
A novel NHEJ gene signature based model for risk stratification and prognosis prediction in hepatocellular carcinoma
BackgroundNon-homologous DNA end joining (NHEJ) is the predominant DNA double-strand break (DSB) repair pathway in human. However, the relationship...
